Results 101 to 110 of about 14,981,197 (293)

D-serine increases adult hippocampal neurogenesis

Frontiers in Neuroscience, 2013
Adult hippocampal neurogenesis results in the continuous formation of new neurons and is a process of brain plasticity involved in learning and memory. The neurogenic niche regulates the stem cell proliferation and the differentiation and survival of new
Sebastien eSultan, Elias Georges Gebara, Kristell eMoullec, Nicolas eToni   +3 more
doaj   +1 more source

D-Serine Is a Substrate for Neutral Amino Acid Transporters ASCT1/SLC1A4 and ASCT2/SLC1A5, and Is Transported by Both Subtypes in Rat Hippocampal Astrocyte Cultures - Fig 7

, 2016
Homo- and hetero-exchange of intracellular [3H]D-serine with extracellular test substrates in oocytes injected with human cRNA encoding SLC1A4 (A) or SLC1A5 (B).
Alan C. Foster (2406511), Ursula Staubli (2822369), Jill Farnsworth (2822378), Yong-Xin Li (1936192), Jia-Ying Yang (448791), Michael P. Kavanaugh (345565), Genevieve E. Lind (2822384), Veena Viswanath (2822375), Van Dang (2822372), Mahmud Penjwini (2822381)   +9 more
core   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

D-Serine made by serine racemase in Drosophila intestine plays a physiological role in sleep

Nature Communications, 2019
The physiological function of endogenous D-serine remains a mystery. Here the authors show that endogenous D-serine plays an important role in regulating sleep and that, while the D-serine synthesizing enzyme serine racemase (SR) is expressed both in the
Xihuimin Dai, Enxing Zhou, Wei Yang, Xiaohui Zhang, Wenxia Zhang, Yi Rao   +5 more
doaj   +1 more source

D-serine as a gliotransmitter and its roles in brain development and disease

Frontiers in Cellular Neuroscience, 2013
The development of new techniques to study glial cells has revealed that they are active participants in the development of functional neuronal circuits. Calcium imaging studies demonstrate that glial cells actively sense and respond to neuronal activity.
Marion R Van Horn, Mari eSild, Edward S Ruthazer   +2 more
doaj   +1 more source

d-Serine is reabsorbed in rat renal pars recta

, 1999
d-Serine normally contributes up to 3% to total plasma serine and up to 23% in chronic renal failure. d-Serine is metabolized by tubular d-amino acid oxidase (D-AAO), and highd-serine plasma levels are nephrotoxic; both events are localized in the ...
Stefan Silbernagl, Katharina Völker, William H. Dantzler   +2 more
core   +1 more source

Enhanced astrocytic d-serine underlies synaptic damage after traumatic brain injury [PDF]

, 2017
After traumatic brain injury (TBI), glial cells have both beneficial and deleterious roles in injury progression and recovery. However, few studies have examined the influence of reactive astrocytes in the tripartite synapse following TBI.
Balu, Darrick T, Stephen A. Tapanes, Darrick T. Balu, Daniel J. Liebl, Zachary B. Loris, Liebl, Daniel J, Thomas J. Sick, Joseph T. Coyle, Tapanes, Stephen A, Loris, Zachary B, Sick, Thomas J, Perez, Enmanuel J, Enmanuel J. Perez, Coyle, Joseph T   +13 more
core   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Contribution of the _D-Serine-dependent pathway to the cellular mechanisms underlying cognitive aging

Frontiers in Aging Neuroscience, 2010
An association between age-related memory impairments and changes in functional plasticity in the aging brain has been under intense study within the last decade.
Emilie Rouaud, Jean-Pierre Mothet
doaj   +1 more source

Astrocytes Coordinate Neurovascular Coupling During Prolonged Sensory Demand via AQP4/TRPA1/BEST1/D-Serine Signaling. [PDF]

Adv Sci (Weinh)
Neuronal activation leads to astrocytic transient volume changes, activating transient receptor potential ankyrin 1 (TRPA1) channels, leading to Ca2+ influx. Activation of TRPA1 causes the release of D‐serine through BEST1. Finally, the augmented extracellular levels of D‐serine boost neuronal activity by binding GluN1‐containing NMDARs, leading to CBV
Han K, Jang MW, Park T, Kim KJ, Drew VJ, Kim S, Kim TY, Park MG, Kim M, Chung SW, Suh M, Lee CJ.   +11 more
europepmc   +2 more sources