Results 251 to 260 of about 544,097 (279)

D-Serine

Current Opinion in Clinical Nutrition and Metabolic Care, 2013
Here, we discuss the recent data on the role of different N-methyl D-aspartate receptor (NMDAR) coagonists, D-serine and glycine, in regulating NMDAR activity and neurotoxicity.D-Serine originates from both neurons and astrocytes, from where it is released by different mechanisms.
Inna, Radzishevsky, Hagit, Sason, Herman, Wolosker   +2 more
openaire   +2 more sources

PEGylated d-serine dehydratase as a d-serine reducing agent

Journal of Pharmaceutical and Biomedical Analysis, 2015
D-Serine is an endogenous coagonist for N-methyl-D-aspartate (NMDA) receptors and is involved in excitatory neurotransmission. Excessive receptor activation causes excitotoxicity, leading to various acute and chronic neurological disorders. Decrease in D-serine content may provide a therapeutic strategy for the treatment of the neurological disorders ...
Tomokazu, Ito, Hiroe, Takada, Keiko, Isobe, Masataka, Suzuki, Yasuyuki, Kitaura, Hisashi, Hemmi, Tsukasa, Matsuda, Jumpei, Sasabe, Tohru, Yoshimura   +8 more
openaire   +2 more sources

Rapid determination of free d-serine with chicken d-serine dehydratase

Journal of Chromatography B, 2011
We have developed a simple, rapid, and inexpensive method of measuring the concentration of intrinsic free D-serine in tissue samples. This method uses chicken D-serine dehydratase in an enzymatic reaction to produce pyruvate, which is detected spectrophotometrically.
Chihiro, Suzuki, Masahito, Murakami, Hirokazu, Yokobori, Hiroyuki, Tanaka, Tetsuo, Ishida, Kihachiro, Horiike, Yoko, Nagata   +6 more
openaire   +2 more sources

Enzymatic assay of d-serine using d-serine dehydratase from Saccharomyces cerevisiae

Analytical Biochemistry, 2007
D-Serine is localized in the mammalian forebrain and modulates brain functions as a coagonist of an N-methyl-D-aspartate receptor. D-Serine is also found in human urine, although its physiological meaning is unclear. A method for rapid and simple assay of D-serine is probably useful for studying its physiological role and clinical relevance. Currently,
Tomokazu, Ito, Kei, Takahashi, Tomoko, Naka, Hisashi, Hemmi, Tohru, Yoshimura   +4 more
openaire   +2 more sources

Metabolism of the neuromodulator d-serine

Cellular and Molecular Life Sciences, 2010
Over the past years, accumulating evidence has indicated that D-serine is the endogenous ligand for the glycine-modulatory binding site on the NR1 subunit of N-methyl-D-aspartate receptors in various brain areas. D-Serine is synthesized in glial cells and neurons by the pyridoxal-5' phosphate-dependent enzyme serine racemase, and it is released upon ...
POLLEGIONI, LOREDANO, SACCHI, SILVIA
openaire   +3 more sources

d-Serine diffusion through the blood–brain barrier: Effect on d-serine compartmentalization and storage

Neurochemistry International, 2012
d-Serine is a co-agonist of N-methyl-d-aspartate (NMDA) receptors. It has been implicated in the etiology of schizophrenia and has shown efficacy as an adjuvant to reduce positive and negative symptoms of schizophrenia. In addition, d-serine can modulate cognition in animals when administered alone.
Pernot P., Maucler C., Tholance Y., Vasylieva N., Debilly G., POLLEGIONI, LOREDANO, Cespuglio R., Marinesco S.   +7 more
openaire   +3 more sources

Effect of risperidone on plasma d-serine concentration in rats post-administered with d-serine

Life Sciences, 2016
Risperidone (Ris) is a second-generation antipsychotic (SGA) used to treat patients with schizophrenia. Additional interventions that increase plasma d-serine (d-Ser) levels could provide improved amelioration of the negative symptoms of schizophrenia.
Mayu, Onozato, Hiromi, Nakazawa, Hitomi, Hakariya, Miho, Shishikura, Chihiro, Nagashima, Katsuyuki, Ishimaru, Tatsuya, Sakamoto, Hideaki, Iizuka, Hideaki, Ichiba, Takeshi, Fukushima   +9 more
openaire   +2 more sources

Eukaryotic d-Serine Dehydratase

2016
In mammals, d-serine is endogenously synthesized by serine racemase (SR), and it plays important roles in memory and learning by binding to the N-methyl-d-aspartate (NMDA) receptor and δ2 glutamate receptor. d-Amino acid oxidase (DAO) is the only mammalian enzyme that degrades d-serine.
Tomokazu Ito, Tohru Yoshimura, Tetsuo Ishida, Hiroyuki Tanaka   +3 more
openaire   +1 more source

d-Serine: The right or wrong isoform?

Brain Research, 2011
Only recently, d-amino acids have been identified in mammals. Of these, d-serine has been most extensively studied. d-Serine was found to play an important role as a neurotransmitter in the human central nervous system (CNS) by binding to the N-methyl-d-aspartate receptor (NMDAr), similar to glycine.
Sabine A, Fuchs, Ruud, Berger, Tom J, de Koning   +2 more
openaire   +2 more sources

D-serine

Brain Research, 2011
Only recently, d-amino acids have been identified in mammals. Of these, d-serine has been most extensively studied. d-Serine was found to play an important role as a neurotransmitter in the human central nervous system (CNS) by binding to the N-methyl-d-aspartate receptor (NMDAr), similar to glycine.
Fuchs, Sabine A, Berger, Ruud, de Koning, Tom J   +2 more
openaire   +1 more source