Results 241 to 250 of about 14,981,197 (293)

D-Serine

Current Opinion in Clinical Nutrition and Metabolic Care, 2013
Here, we discuss the recent data on the role of different N-methyl D-aspartate receptor (NMDAR) coagonists, D-serine and glycine, in regulating NMDAR activity and neurotoxicity.D-Serine originates from both neurons and astrocytes, from where it is released by different mechanisms.
Inna, Radzishevsky, Hagit, Sason, Herman, Wolosker   +2 more
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PEGylated d-serine dehydratase as a d-serine reducing agent

Journal of Pharmaceutical and Biomedical Analysis, 2015
D-Serine is an endogenous coagonist for N-methyl-D-aspartate (NMDA) receptors and is involved in excitatory neurotransmission. Excessive receptor activation causes excitotoxicity, leading to various acute and chronic neurological disorders. Decrease in D-serine content may provide a therapeutic strategy for the treatment of the neurological disorders ...
Tomokazu, Ito, Hiroe, Takada, Keiko, Isobe, Masataka, Suzuki, Yasuyuki, Kitaura, Hisashi, Hemmi, Tsukasa, Matsuda, Jumpei, Sasabe, Tohru, Yoshimura   +8 more
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Rapid determination of free d-serine with chicken d-serine dehydratase

Journal of Chromatography B, 2011
We have developed a simple, rapid, and inexpensive method of measuring the concentration of intrinsic free D-serine in tissue samples. This method uses chicken D-serine dehydratase in an enzymatic reaction to produce pyruvate, which is detected spectrophotometrically.
Chihiro, Suzuki, Masahito, Murakami, Hirokazu, Yokobori, Hiroyuki, Tanaka, Tetsuo, Ishida, Kihachiro, Horiike, Yoko, Nagata   +6 more
openaire   +2 more sources

Enzymatic assay of d-serine using d-serine dehydratase from Saccharomyces cerevisiae

Analytical Biochemistry, 2007
D-Serine is localized in the mammalian forebrain and modulates brain functions as a coagonist of an N-methyl-D-aspartate receptor. D-Serine is also found in human urine, although its physiological meaning is unclear. A method for rapid and simple assay of D-serine is probably useful for studying its physiological role and clinical relevance. Currently,
Tomokazu, Ito, Kei, Takahashi, Tomoko, Naka, Hisashi, Hemmi, Tohru, Yoshimura   +4 more
openaire   +2 more sources

Effect of risperidone on plasma d-serine concentration in rats post-administered with d-serine

Life Sciences, 2016
Risperidone (Ris) is a second-generation antipsychotic (SGA) used to treat patients with schizophrenia. Additional interventions that increase plasma d-serine (d-Ser) levels could provide improved amelioration of the negative symptoms of schizophrenia.
Mayu, Onozato, Hiromi, Nakazawa, Hitomi, Hakariya, Miho, Shishikura, Chihiro, Nagashima, Katsuyuki, Ishimaru, Tatsuya, Sakamoto, Hideaki, Iizuka, Hideaki, Ichiba, Takeshi, Fukushima   +9 more
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d-Serine diffusion through the blood–brain barrier: Effect on d-serine compartmentalization and storage

Neurochemistry International, 2012
d-Serine is a co-agonist of N-methyl-d-aspartate (NMDA) receptors. It has been implicated in the etiology of schizophrenia and has shown efficacy as an adjuvant to reduce positive and negative symptoms of schizophrenia. In addition, d-serine can modulate cognition in animals when administered alone.
Pernot P., Maucler C., Tholance Y., Vasylieva N., Debilly G., POLLEGIONI, LOREDANO, Cespuglio R., Marinesco S.   +7 more
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The Origin and Turnover of D-Serine in Brain

Biochemical and Biophysical Research Communications, 1997
The origin of D-serine was investigated using microdialysis probes to administer radiolabeled glucose, glycine, and L-serine directly into rat brain. In these experiments the labeling of D-serine was found to be determined only by the radioactivity present in the L-serine pool, regardless of the precursor employed, indicating that L-serine is the ...
D S, Dunlop, A, Neidle
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d-Serine: The right or wrong isoform?

Brain Research, 2011
Only recently, d-amino acids have been identified in mammals. Of these, d-serine has been most extensively studied. d-Serine was found to play an important role as a neurotransmitter in the human central nervous system (CNS) by binding to the N-methyl-d-aspartate receptor (NMDAr), similar to glycine.
Sabine A, Fuchs, Ruud, Berger, Tom J, de Koning   +2 more
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d-Serine in the aging hippocampus

Journal of Pharmaceutical and Biomedical Analysis, 2015
Experimental evidences now indicate that memory formation relies on the capacity of neuronal networks to manage long-term changes in synaptic communication. This property is driven by N-methyl-D-aspartate receptors (NMDAR), which requires the binding of glutamate but also the presence of the co-agonist D-serine at the glycine site.
openaire   +3 more sources