Results 241 to 250 of about 10,883,538 (292)

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

A Sprayable Nanoplatform Breaks the Vicious Cycle of Diabetic Wounds via Photoactivated Antioxidant and Drug Delivery

Advanced Science, EarlyView.
A sprayable near‐infrared‐activated nanoplatform incorporating MXene, ZnHCF nanozyme, and deferoxamine efficiently breaks the vicious cycle of diabetic wounds. Upon irradiation, interfacial electron transfer and photothermal effects enhance multi‐enzyme activity, enabling explosive ROS elimination, alleviation of hypoxia, and controlled DFO release ...
Jiahao Guo, Yuanyuan Meng, Qixiang Gui, Xi‐Tao Yang, Yong Fan, Xiaodong Zhu   +5 more
wiley   +1 more source

Resistant Peanut Genotype Reprograms Rhizosphere Metabolism to Enhance Bacterial Wilt Suppression

Advanced Science, EarlyView.
The resistant peanut genotype selectively recruits beneficial bacteria, which coincides with the activation of salicylic acid (SA)‐dependent systemic acquired resistance (SAR) against Ralstonia solanacearum. Keystone rhizosphere metabolites are positively correlated with both beneficial microbiome assembly and SAR gene expression.
Rui Ren, Xiaogang Li, Hao Li, Zenghui Cao, Mengtian Hou, Chunlei Zhao, Nan Lou, Sasa Hu, Yanzhe Li, Qian Ma, Yaoyao Li, Yi Fan, Kunkun Zhao, Kai Zhao, Ding Qiu, Fangping Gong, Zhongfeng Li, Haitao Liu, Xingli Ma, Xingxiang Wang, Dongmei Yin   +20 more
wiley   +1 more source

Metabolism of the neuromodulator d-serine

Cellular and Molecular Life Sciences, 2010
Over the past years, accumulating evidence has indicated that D-serine is the endogenous ligand for the glycine-modulatory binding site on the NR1 subunit of N-methyl-D-aspartate receptors in various brain areas. D-Serine is synthesized in glial cells and neurons by the pyridoxal-5' phosphate-dependent enzyme serine racemase, and it is released upon ...
POLLEGIONI, LOREDANO, SACCHI, SILVIA
openaire   +4 more sources

d-Serine: The right or wrong isoform?

Brain Research, 2011
Only recently, d-amino acids have been identified in mammals. Of these, d-serine has been most extensively studied. d-Serine was found to play an important role as a neurotransmitter in the human central nervous system (CNS) by binding to the N-methyl-d-aspartate receptor (NMDAr), similar to glycine.
Sabine A, Fuchs, Ruud, Berger, Tom J, de Koning   +2 more
openaire   +3 more sources

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D-Serine

Current Opinion in Clinical Nutrition and Metabolic Care, 2013
Here, we discuss the recent data on the role of different N-methyl D-aspartate receptor (NMDAR) coagonists, D-serine and glycine, in regulating NMDAR activity and neurotoxicity.D-Serine originates from both neurons and astrocytes, from where it is released by different mechanisms.
Inna, Radzishevsky, Hagit, Sason, Herman, Wolosker   +2 more
openaire   +2 more sources

PEGylated d-serine dehydratase as a d-serine reducing agent

Journal of Pharmaceutical and Biomedical Analysis, 2015
D-Serine is an endogenous coagonist for N-methyl-D-aspartate (NMDA) receptors and is involved in excitatory neurotransmission. Excessive receptor activation causes excitotoxicity, leading to various acute and chronic neurological disorders. Decrease in D-serine content may provide a therapeutic strategy for the treatment of the neurological disorders ...
Tomokazu, Ito, Hiroe, Takada, Keiko, Isobe, Masataka, Suzuki, Yasuyuki, Kitaura, Hisashi, Hemmi, Tsukasa, Matsuda, Jumpei, Sasabe, Tohru, Yoshimura   +8 more
openaire   +2 more sources

Rapid determination of free d-serine with chicken d-serine dehydratase

Journal of Chromatography B, 2011
We have developed a simple, rapid, and inexpensive method of measuring the concentration of intrinsic free D-serine in tissue samples. This method uses chicken D-serine dehydratase in an enzymatic reaction to produce pyruvate, which is detected spectrophotometrically.
Chihiro, Suzuki, Masahito, Murakami, Hirokazu, Yokobori, Hiroyuki, Tanaka, Tetsuo, Ishida, Kihachiro, Horiike, Yoko, Nagata   +6 more
openaire   +2 more sources

Enzymatic assay of d-serine using d-serine dehydratase from Saccharomyces cerevisiae

Analytical Biochemistry, 2007
D-Serine is localized in the mammalian forebrain and modulates brain functions as a coagonist of an N-methyl-D-aspartate receptor. D-Serine is also found in human urine, although its physiological meaning is unclear. A method for rapid and simple assay of D-serine is probably useful for studying its physiological role and clinical relevance. Currently,
Tomokazu, Ito, Kei, Takahashi, Tomoko, Naka, Hisashi, Hemmi, Tohru, Yoshimura   +4 more
openaire   +2 more sources