Results 251 to 260 of about 10,883,538 (292)
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Effect of risperidone on plasma d-serine concentration in rats post-administered with d-serine
Life Sciences, 2016Risperidone (Ris) is a second-generation antipsychotic (SGA) used to treat patients with schizophrenia. Additional interventions that increase plasma d-serine (d-Ser) levels could provide improved amelioration of the negative symptoms of schizophrenia.
Mayu, Onozato +9 more
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Neurochemistry International, 2012
d-Serine is a co-agonist of N-methyl-d-aspartate (NMDA) receptors. It has been implicated in the etiology of schizophrenia and has shown efficacy as an adjuvant to reduce positive and negative symptoms of schizophrenia. In addition, d-serine can modulate cognition in animals when administered alone.
Pernot P. +7 more
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d-Serine is a co-agonist of N-methyl-d-aspartate (NMDA) receptors. It has been implicated in the etiology of schizophrenia and has shown efficacy as an adjuvant to reduce positive and negative symptoms of schizophrenia. In addition, d-serine can modulate cognition in animals when administered alone.
Pernot P. +7 more
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The Origin and Turnover of D-Serine in Brain
Biochemical and Biophysical Research Communications, 1997The origin of D-serine was investigated using microdialysis probes to administer radiolabeled glucose, glycine, and L-serine directly into rat brain. In these experiments the labeling of D-serine was found to be determined only by the radioactivity present in the L-serine pool, regardless of the precursor employed, indicating that L-serine is the ...
D S, Dunlop, A, Neidle
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Glial transport of the neuromodulator d-serine
Brain Research, 2002D-Serine is an endogenous agonist of NMDA receptors that occurs in astrocytes in gray matter areas of the brain. D-Serine is synthesized from L-serine by the activity of a glial enriched serine racemase, but little is known on the properties of D-serine transport and factors regulating its synaptic concentration.
Cátia S, Ribeiro +4 more
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Contributions of the d-serine pathway to schizophrenia
Neuropharmacology, 2012The glutamate neurotransmitter system is one of the major candidate pathways for the pathophysiology of schizophrenia, and increased understanding of the pharmacology, molecular biology and biochemistry of this system may lead to novel treatments. Glutamatergic hypofunction, particularly at the NMDA receptor, has been hypothesized to underlie many of ...
Viviane, Labrie +2 more
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Pharmacokinetics and toxicokinetics of d-serine in rats
Journal of Pharmaceutical and Biomedical Analysis, 2019In the mammalian brain, d-serine acts as a co-agonist at the glycine-binding site on the N-methyl-d-aspartate receptor. Because plasma d-serine levels are significantly lower in patients with schizophrenia than in healthy subjects, d-serine has been proposed as a potential therapeutic agent for schizophrenia treatment.
Hiroshi, Hasegawa +4 more
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d-Serine in the aging hippocampus
Journal of Pharmaceutical and Biomedical Analysis, 2015Experimental evidences now indicate that memory formation relies on the capacity of neuronal networks to manage long-term changes in synaptic communication. This property is driven by N-methyl-D-aspartate receptors (NMDAR), which requires the binding of glutamate but also the presence of the co-agonist D-serine at the glycine site.
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Occurrence of Free D-Serine in the Earthworm
Nature, 1960LOMBRICINE was first isolated from the earthworm by Thoai and Robin1. Analysis of the crystalline material isolated in this laboratory2 showed that the serine component was of the D-configuration3. Serine ethanolamine phosphodiester, which has been shown to be a precursor of lombricine in the earthworm4, has been isolated in the crystalline form and ...
H, ROSENBERG, A H, ENNOR
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Brain Research, 2011
Only recently, d-amino acids have been identified in mammals. Of these, d-serine has been most extensively studied. d-Serine was found to play an important role as a neurotransmitter in the human central nervous system (CNS) by binding to the N-methyl-d-aspartate receptor (NMDAr), similar to glycine.
Fuchs, Sabine A +2 more
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Only recently, d-amino acids have been identified in mammals. Of these, d-serine has been most extensively studied. d-Serine was found to play an important role as a neurotransmitter in the human central nervous system (CNS) by binding to the N-methyl-d-aspartate receptor (NMDAr), similar to glycine.
Fuchs, Sabine A +2 more
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The Neurobiology of d -Serine Signaling
2018d-Serine is a physiological coagonist of NMDA receptors involved in synaptic plasticity, neurodevelopment, and neurodegeneration. d-Serine is synthesized by the enzyme serine racemase, which converts l- to d-serine. Recent studies indicate that the supply of l-serine by astroglia fuels the neuronal synthesis of d-serine.
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