Results 251 to 260 of about 14,981,197 (293)

Glial transport of the neuromodulator d-serine

Brain Research, 2002
D-Serine is an endogenous agonist of NMDA receptors that occurs in astrocytes in gray matter areas of the brain. D-Serine is synthesized from L-serine by the activity of a glial enriched serine racemase, but little is known on the properties of D-serine transport and factors regulating its synaptic concentration.
Cátia S, Ribeiro, Marcelo, Reis, Rogério, Panizzutti, Joari, de Miranda, Herman, Wolosker   +4 more
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Contributions of the d-serine pathway to schizophrenia

Neuropharmacology, 2012
The glutamate neurotransmitter system is one of the major candidate pathways for the pathophysiology of schizophrenia, and increased understanding of the pharmacology, molecular biology and biochemistry of this system may lead to novel treatments. Glutamatergic hypofunction, particularly at the NMDA receptor, has been hypothesized to underlie many of ...
Viviane, Labrie, Albert H C, Wong, John C, Roder   +2 more
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Pharmacokinetics and toxicokinetics of d-serine in rats

Journal of Pharmaceutical and Biomedical Analysis, 2019
In the mammalian brain, d-serine acts as a co-agonist at the glycine-binding site on the N-methyl-d-aspartate receptor. Because plasma d-serine levels are significantly lower in patients with schizophrenia than in healthy subjects, d-serine has been proposed as a potential therapeutic agent for schizophrenia treatment.
Hiroshi, Hasegawa, Nami, Masuda, Hiromi, Natori, Yoshihiko, Shinohara, Kimiyoshi, Ichida   +4 more
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D-serine

Brain Research, 2011
Only recently, d-amino acids have been identified in mammals. Of these, d-serine has been most extensively studied. d-Serine was found to play an important role as a neurotransmitter in the human central nervous system (CNS) by binding to the N-methyl-d-aspartate receptor (NMDAr), similar to glycine.
Fuchs, Sabine A, Berger, Ruud, de Koning, Tom J   +2 more
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Occurrence of Free D-Serine in the Earthworm

Nature, 1960
LOMBRICINE was first isolated from the earthworm by Thoai and Robin1. Analysis of the crystalline material isolated in this laboratory2 showed that the serine component was of the D-configuration3. Serine ethanolamine phosphodiester, which has been shown to be a precursor of lombricine in the earthworm4, has been isolated in the crystalline form and ...
H, ROSENBERG, A H, ENNOR
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The Neurobiology of d -Serine Signaling

2018
d-Serine is a physiological coagonist of NMDA receptors involved in synaptic plasticity, neurodevelopment, and neurodegeneration. d-Serine is synthesized by the enzyme serine racemase, which converts l- to d-serine. Recent studies indicate that the supply of l-serine by astroglia fuels the neuronal synthesis of d-serine.
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Serine Racemase and D-Serine Transport in Human Placenta and Evidence for a Transplacental Gradient for D-Serine in Humans

Journal of the Society for Gynecologic Investigation, 2004
To investigate the possible role of human placenta in providing D-serine to the developing fetus.Expression of serine racemase in placenta was determined by reverse transcriptase polymerase chain reaction and northern analysis and confirmed by subsequent cloning.
Zhong, Chen, Wei, Huang, Sonne R, Srinivas, Chandra R, Jones, Vadivel, Ganapathy, Puttur D, Prasad   +5 more
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Eukaryotic d-Serine Dehydratase

2016
In mammals, d-serine is endogenously synthesized by serine racemase (SR), and it plays important roles in memory and learning by binding to the N-methyl-d-aspartate (NMDA) receptor and δ2 glutamate receptor. d-Amino acid oxidase (DAO) is the only mammalian enzyme that degrades d-serine.
Tomokazu Ito, Tohru Yoshimura, Tetsuo Ishida, Hiroyuki Tanaka   +3 more
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d-Serine Signaling and Schizophrenia

2016
It has been widely accepted that the hypofunction of the N-methyl-d-aspartate-type glutamate receptor (NMDAR) may be implicated in the pathophysiology of both positive- and negative-cognitive symptomatologies of schizophrenia because NMDAR antagonists, including phencyclidine (PCP) and anti-NMDAR antibodies, mimic these respective antipsychotic ...
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d-Serine and the Pathophysiology of Schizophrenia

2016
Schizophrenia is a chronic, disabling psychiatric disorder characterized by psychosis, cognitive impairments, and negative symptoms such as social withdrawal and anhedonia. Pathologic changes in the brain include cortical atrophy, loss of pyramidal cell dendritic complexity and spine density, ventricular enlargement, and reduction in intracellular ...
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