Results 261 to 270 of about 544,097 (279)

d-Serine in the aging hippocampus

Journal of Pharmaceutical and Biomedical Analysis, 2015
Experimental evidences now indicate that memory formation relies on the capacity of neuronal networks to manage long-term changes in synaptic communication. This property is driven by N-methyl-D-aspartate receptors (NMDAR), which requires the binding of glutamate but also the presence of the co-agonist D-serine at the glycine site.
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Glial transport of the neuromodulator d-serine

Brain Research, 2002
D-Serine is an endogenous agonist of NMDA receptors that occurs in astrocytes in gray matter areas of the brain. D-Serine is synthesized from L-serine by the activity of a glial enriched serine racemase, but little is known on the properties of D-serine transport and factors regulating its synaptic concentration.
Cátia S, Ribeiro, Marcelo, Reis, Rogério, Panizzutti, Joari, de Miranda, Herman, Wolosker   +4 more
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The Neurobiology of d -Serine Signaling

2018
d-Serine is a physiological coagonist of NMDA receptors involved in synaptic plasticity, neurodevelopment, and neurodegeneration. d-Serine is synthesized by the enzyme serine racemase, which converts l- to d-serine. Recent studies indicate that the supply of l-serine by astroglia fuels the neuronal synthesis of d-serine.
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Occurrence of Free D-Serine in the Earthworm

Nature, 1960
LOMBRICINE was first isolated from the earthworm by Thoai and Robin1. Analysis of the crystalline material isolated in this laboratory2 showed that the serine component was of the D-configuration3. Serine ethanolamine phosphodiester, which has been shown to be a precursor of lombricine in the earthworm4, has been isolated in the crystalline form and ...
H, ROSENBERG, A H, ENNOR
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d-Serine Signaling and Schizophrenia

2016
It has been widely accepted that the hypofunction of the N-methyl-d-aspartate-type glutamate receptor (NMDAR) may be implicated in the pathophysiology of both positive- and negative-cognitive symptomatologies of schizophrenia because NMDAR antagonists, including phencyclidine (PCP) and anti-NMDAR antibodies, mimic these respective antipsychotic ...
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[184] d-serine dehydrase (Escherichia coli)

1971
Publisher Summary This chapter discusses the methods of preparation of D -Serine Dehydrase ( Escherichia coli ). The dehydration of D -serine, catalyzed by D -serine dehydrase, continues until all of the amino acid is converted to pyruvate and ammonia.
William G. Robinson, Rosalind Labow
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[Endogenous D-serine in mammalian brains].

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 2000
It is well established that, like glycine and D-alanine, D-serine potentiates glutamate neurotransmission via the N-methyl-D-aspartate (NMDA) receptor by selective stimulation of its strychnine-insensitive glycine site and acts as a co-agonist of the glutamate receptor.
T, Nishikawa, N, Yamamoto, H, Tsuchida, A, Umino, N, Kawaguchi   +4 more
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D-Serine dehydratase of earthworm tissues

Biochimica et Biophysica Acta (BBA) - Enzymology and Biological Oxidation, 1965
D, Fujimoto, E, Adams
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Mycobacterial d-serine impairs TB control

Nature Immunology
Maxime Caouaille, Denis Hudrisier, Olivier Neyrolles   +2 more
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Disposition of D‐Serine in Healthy Adults

The Journal of Clinical Pharmacology, 2008
Guochuan E, Tsai, Hsien-Yuan, Lane, Chad M, Vandenberg, Yi-Ching, Liu, Priscilla, Tsai, Michael W, Jann   +5 more
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