Results 41 to 50 of about 544,097 (279)
Evidence for the interaction of d-amino acid oxidase with pLG72 in a glial cell line. [PDF]
, 2011 Accumulating genetic evidence indicates that the primate-specific gene locus G72/G30 is related to schizophrenia: it encodes for the protein pLG72, whose function is still the subject of controversy. We recently demonstrated that pLG72 negatively affects
Cappelletti, P. +3 more
core +1 more source
Journal of Pharmacological Sciences, 2008 Recent studies indicate that an endogenous co-agonist for an N-methyl-D-aspartate (NMDA) receptor–related glycine site, D-serine, is synthesized by serine racemase and is metabolized by D-amino acid oxidase (DAO) and that acute treatment with morphine ...
Masanobu Yoshikawa +7 more
doaj +1 more source
d-serine in physiological and pathological brain aging
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2021 Among aging-induced impairments, those affecting cognitive functions certainly represent one the most major challenge to face to improve elderly quality of life. In last decades, our knowledge on changes in the morphology and function of neuronal networks associated with normal and pathological brain aging has rapidly progressed, initiating the ...
Ploux, E. +2 more
openaire +5 more sources
A conditional marker gene allowing both positive and negative selection in plants [PDF]
, 2004 Selectable markers enable transgenic plants or cells to be identified after transformation. They can be divided into positive and negative markers conferring a selective advantage or disadvantage, respectively.
Erikson, Oskar +2 more
core +1 more source
PLoS ONE, 2013 BackgroundD-Serine, an endogenous co-agonist of the N-methyl-D-aspartate (NMDA) receptor, is synthesized from L-serine by serine racemase (SRR). Given the role of D-serine in both neurodevelopment and the pathophysiology of schizophrenia, we examined ...
Hiroko Hagiwara +2 more
doaj +1 more source
The study of chiral adsorption systems using synchrotron- based structural and spectroscopic techniques: stereospecific adsorption of serine on Au-modified chiral Cu{531} surfaces [PDF]
, 2011 We apply modern synchrotron-based structural techniques to the study of serine adsorbed on the pure andAumodified intrinsically chiral Cu{531} surface.
Cornish, Alix +3 more
core +1 more source
Translational Psychiatry, 2021 d-Serine acts as a co-agonist of N-methyl-d-aspartate receptors (NMDAR) which appear overactivated in AD, while d-aspartate is a modulatory molecule acting on NMDAR as a second agonist.
Luciano Piubelli +6 more
doaj +1 more source
d-Serine: A key to synaptic plasticity? [PDF]
The International Journal of Biochemistry & Cell Biology, 2012 Two discoveries have put D-serine in the spotlight of neuroscience. First, D-serine was detected in brain tissue at high levels. Second, it was found to act on the N-methyl-D-aspartate receptor (NMDAR). This receptor is central to use-dependent synaptic plasticity, the cellular process which is widely believed to underlie learning.
Christian, Henneberger +2 more
openaire +2 more sources
Characterisation of the pathogenic effects of the in vivo expression of an ALS-linked mutation in D-amino acid oxidase: Phenotype and loss of spinal cord motor neurons [PDF]
, 2017 Amyotrophic lateral sclerosis (ALS) is the most common adult-onset neuromuscular disorder characterised by selective loss of motor neurons leading to fatal paralysis. Current therapeutic approaches are limited in their effectiveness. Substantial advances
A Gill +49 more
core +2 more sources
Effects of Chronic D-Serine Elevation on Animal Models of Depression and Anxiety-Related Behavior.
PLoS ONE, 2013 NMDA receptors are activated after binding of the agonist glutamate to the NR2 subunit along with a co-agonist, either L-glycine or D-serine, to the NR1 subunit.
David-Marian Otte +7 more
doaj +1 more source