Results 71 to 80 of about 14,981,197 (293)

Phosphorylation of mouse serine racemase regulates D-serine synthesis

, 2010
Serine racemase (SR) catalyses the synthesis of the transmitter/neuromodulator D-serine, which plays a major role in synaptic plasticity and N-methyl D-aspartate receptor neurotoxicity.
Foltyn, Veronika N, Wolosker, Herman, Zehl, Martin, Dikopoltsev, Elena, Jensen, Ole N; id_orcid   +4 more
core   +2 more sources

Preferred stereoselective brain uptake of D-serine - a modulator of glutamatergic neurotransmission

, 2005
Although it has long been presumed that d-amino acids are uncommon in mammalians, substantial amounts of free d-serine have been detected in the mammalian brain.
Hamacher, Kurt, Coenen, Heinz H., Bauer, D., Palm, Christoph, Langen, Karl-Josef, Palm, C., Pauleit, D., Zilles, K., Pauleit, Dirk, Hamacher, K., Bauer, Dagmar, Bröer, S., Coenen, H. H., Zilles, Karl, Langen, K. J., Bröer, Stefan   +15 more
core   +1 more source

d-Serine controls epidermal vesicle release via NMDA receptor, allowing tissue migration during the metamorphosis of the chordate .

, 2022
d-Serine, a free amino acid synthesized by serine racemase, is a coagonist of N-methyl-d-aspartate-type glutamate receptor (NMDAR). d-Serine in the mammalian central nervous system modulates glutamatergic transmission.
Krasovec, Gabriel, Obita, Takayuki, Hozumi, Akiko, Satake, Honoo, Mori, Hisashi, Shiraishi, Akira, Horie, Takeo, Sasakura, Yasunori, Yoshida, Tomoyuki, Hamada, Mayuko   +9 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Antinociceptive Effect of Rat D-Serine Racemase Inhibitors, L-Serine-O-Sulfate, and L-Erythro-3-Hydroxyaspartate in an Arthritic Pain Model

The Scientific World Journal, 2012
N-methyl-D-aspartic acid receptor (NMDAr) activation requires the presence of D-serine, synthesized from L-serine by a pyridoxal 5′-phosphate-dependent serine racemase (SR). D-serine levels can be lowered by inhibiting the racemization of L-serine.
Claudio Laurido, Alejandro Hernández, Teresa Pelissier, Luis Constandil   +3 more
doaj   +1 more source

D-Serine: Potential Therapeutic Agent and/or Biomarker in Schizophrenia and Depression?

Frontiers in Psychiatry, 2019
D-Serine is a potent co-agonist at the NMDA glutamate receptor and has been the object of many preclinical studies to ascertain the nature of its metabolism, its regional and cellular distribution in the brain, its physiological functions and its ...
Mary-Anne B. MacKay, Mary-Anne B. MacKay, Maryana Kravtsenyuk, Maryana Kravtsenyuk, Rejish Thomas, Nicholas D. Mitchell, Nicholas D. Mitchell, Serdar M. Dursun, Serdar M. Dursun, Glen B. Baker, Glen B. Baker   +10 more
doaj   +1 more source

In Vivo d-Serine Hetero-Exchange through Alanine-Serine-Cysteine (ASC) Transporters Detected by Microelectrode Biosensors.

, 2013
d-Serine, a co-agonist of N-methyl d-aspartate (NMDA) receptors, has been implicated in neurological and psychiatric disorders such as cerebral ischemia, lateral amyotrophic sclerosis, or schizophrenia.
P. Pernot, Pierre Pernot, N. Vasylieva, Natalia Vasylieva, POLLEGIONI, LOREDANO, Caroline Maucler, Loredano Pollegioni, C. Maucler, Stéphane Marinesco, S. Marinesco   +9 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

The presence of free D‐serine in rat brain

FEBS Letters, 1992
Free amino acid enantiomers in adult rat brain extracts were analysed as their N,O‐pentafluoropropionyl isopropyl derivatives by gas chromatography on a capillary column of Chirasil‐L‐Val. A peak X, which exhibited the same retention time as the N,O‐pentafluoropropionyl isopropyl derivative of authentic D‐serine, was detected in the brain extracts ...
Hashimoto, Atsushi, Nishikawa, Toru, Hayashi, Tohiski, Fujii, Noriko, Harada, Kaoru, Oka, Takae, Takahashi, Kiyohisa   +6 more
openaire   +2 more sources