Results 81 to 90 of about 544,097 (279)

Induction of serine racemase expression and D-serine release from microglia by amyloid β-peptide

Journal of Neuroinflammation, 2004
Background Roles for excitotoxicity and inflammation in Alzheimer's disease have been hypothesized. Proinflammatory stimuli, including amyloid β-peptide (Aβ), elicit a release of glutamate from microglia. We tested the possibility that a coagonist at the
Griffin W Sue T, Porter Mandy M, Bodles Angela M, Wu Sheng-Zhou, Basile Anthony S, Barger Steven W   +5 more
doaj   +1 more source

Regulating levels of the neuromodulator D-serine in human brain: structural insight into pLG72 and D-amino acid oxidase interaction [PDF]

, 2016
The human flavoenzyme D-amino acid oxidase (hDAAO) degrades the NMDA-receptor modulator D-serine in the brain. Whereas hDAAO has been extensively characterized, little is known about its main modulator pLG72, a small protein encoded by the primate ...
Bagetta, Braun, Caldinelli, Caldinelli, Cappelletti, Casbarra, Chang, Cheng, Chu, Chumakov, Colovos, Demuro, Detera-Wadleigh, Frishman, Habchi, Hanwell, Harrison, Harrison, Kawazoe, Krissinel, Kvajo, Labrie, Lewis, Machado-Vieira, Marino, Merkley, Molla, Molla, Mundo, Mädler, Papouin, Pierce, Pollegioni, Pollegioni, Ross, Roy, Sacchi, Sacchi, Sacchi, Sacchi, Sasabe, Scaloni, Schumacher, Sehgal, Sehgal, Sinz, Sinz, Terry-Lorenzo, Tompa, Trnka, Trott, Verrall, Wolosker, Wolosker, Zappacosta   +54 more
core   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Hyperaminoaciduria in Rats Following D-Serine Administration.

Experimental Biology and Medicine, 1966
Fishman and Artom showed that DL-serine was highly toxic to the rat(2). Later papers from their laboratory(3–7), and from that of Wachstein(8–10) implicated the kidney as a prime site for the toxic action of DL-serine. Comparable doses of L-serine were non-toxic (4).
E M, Wise, D, Elwyn
openaire   +2 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Genome sequencing analysis of Streptomyces coelicolor mutants that overcome the phosphate-depending vancomycin lethal effect [PDF]

, 2018
Background Glycopeptide antibiotics inhibit bacterial cell-wall synthesis, and are important for the treatment of infections caused by multi drug-resistant strains of enterococci, streptococci and staphylococci.
Santos Beneit, Fernando
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Astrocytes release d-serine by a large vesicle [PDF]

Neuroscience, 2013
Long-term potentiation (LTP) of synaptic transmission in the CA1 region of the hippocampus depends on the activation of N-methyl-D-aspartate receptors (NMDARs), which can be regulated by Ca²⁺-dependent release of D-serine from astrocytes. The detailed mechanism underlying astrocytic d-serine release is still unknown. In hippocampal slices prepared from
Kang, Ning, Peng, Hong, Yu, Yufei, Stanton, Patric K., Guilarte, Tomás R., Kang, Jian   +5 more
openaire   +2 more sources

Immunogold Detection of L-glutamate and D-serine in Small Synaptic-Like Microvesicles in Adult Hippocampal Astrocytes [PDF]

, 2017
Glutamate and the N-methyl-D-aspartate receptor ligand D-serine are putative gliotransmitters. Here, we show by immunogold cytochemistry of the adult hippocampus that glutamate and D-serine accumulate in synaptic-like microvesicles (SLMVs) in the ...
Bergersen, L.H., Bouvier, D., Gundersen, V., Larsson, M., Morland, C., Ormel, L., Ottersen, O.P., Rinholm, J.E., Røe, Å.T., Santello, M., Stranna, A., Volterra, A., Wold, J.F.H.   +12 more
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source