Results 171 to 180 of about 258,771 (261)

PKA signaling modulates PRMT5/hnRNP A1-mediated IRES translation and dictates responses to mTOR inhibition in glioblastoma. [PDF]

J Neurooncol
Kumar S, Benavides-Serrato A, Saunders JT, Nishimura RN, Gera JF.   +4 more
europepmc   +1 more source

Unraveling the Plasma Extracellular Vesicles Proteome: Predictors of Resistance in Immunotherapy of Advanced Melanoma

International Journal of Cancer, EarlyView.
ABSTRACT Despite substantial clinical benefit from immune checkpoint inhibitors (ICI), advanced melanoma remains challenging due to frequent treatment resistance. Resistance may be intrinsic (primary) or emerge over time (secondary). Biomarkers predicting distinct resistance phenotypes before therapy are lacking.
Julian Kött, Glenn Geidel, Carmen M. T. Roeper, Lucija Ačkar, Bente Siebels, Hannah Voß, Hartmut Schlüter, Michaela Schweizer, Kilian Müller, Alessandra Rünger, Tim Zell, Benjamin Deitert, Ali Zeinal‐Abedini, Isabel Heidrich, Stefan W. Schneider, Klaus Pantel, Daniel J. Smit, Christoffer Gebhardt   +17 more
wiley   +1 more source

Characterization and modulation of human insulin degrading enzyme conformational dynamics to control enzyme activity. [PDF]

Elife
Mancl JM, Liang WG, Bayhi NL, Wei H, Budell WC, Mendez JH, Sosnick TR, Carragher B, Potter CS, Potter CS, Tang WJ.   +10 more
europepmc   +1 more source

Comparing functionality, anxiety and depression during pregnancy and postpartum in women with hypertensive disorders: Findings from the WOICE assessment

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To describe the use of the WOICE tool for assessing non‐severe maternal morbidities among pregnant and postpartum women with hypertensive disorders. Methods Secondary analysis of a previously published cross‐sectional study performed in Brazil, with the inclusion of women with hypertensive disorders (pre‐eclampsia, chronic ...
Stephanie Pabón Lozano, José Paulo Siqueira Guida, Charles Mpoca Charles, Helen Johana Ortiz Rojas, Carolina Gómez Muñoz, Jose Guilherme Cecatti, Maria Laura Costa   +6 more
wiley   +1 more source

The contribution of the ²⁴⁰Ala:Glu:Glu:Thr²⁴³ sequence in the DE-loop of D2 to the acceptor side of Photosystem II. [PDF]

Photosynth Res
Khaing EP, Summerfield TC, Forsman JA, Vass I, Patil PP, Eaton-Rye JJ.   +5 more
europepmc   +1 more source

Reversing brain aging: Targeting energy metabolism in endogenous neural stem cells

Interdisciplinary Medicine, EarlyView.
Mechanism of endogenous neural stem cells (eNSCs) energy metabolism disorder leading to brain aging and targeted eNSCs intervention strategies (By biorender). The disorder of energy metabolism of eNSCs can lead to their resting and aging, and eventually lead to brain aging.
Chong Chen, Jiayi Wang, Jimin Yu, Yiran Zhou, Lihai Liu, Jing Liu, Liang Wang   +6 more
wiley   +1 more source

Drought Risk in Mango and Avocado Orchards: Insights Into Plant Water Relations and Irrigation‐Related Agronomic Solutions

Irrigation and Drainage, EarlyView.
ABSTRACT Climate change is making water availability more uncertain, with growing consequences for the productivity and long‐term sustainability of tropical and subtropical fruit orchards. Mangifera indica L. and Persea americana Mill. both require large amounts of water to sustain growth and productivity.
Eleonora Cataldo
wiley   +1 more source

Increasing plant protein sources in the diet modulates gut microbiota and tryptophan metabolism in men at cardiometabolic risk. [PDF]

Gut Microbes
Lépine G, Davila AM, Cueff G, Pickering G, Ichou F, Perreau C, Lefranc-Millot C, Gilles M, Thirion F, Mariotti F, Rémond D, Fouillet H, Polakof S.   +12 more
europepmc   +1 more source

Mode‐of‐Action and Human Relevance Assessment for Diisononyl Phthalate‐Induced Liver Tumors in Rodents

Journal of Applied Toxicology, EarlyView.
ABSTRACT Diisononyl phthalate (DINP) is a high molecular weight phthalate and high production volume chemical. DINP's carcinogenic potential has been investigated in four rodent bioassays, with liver tumors observed in three of the studies. Authoritative assessments have hypothesized that DINP acts through the peroxisome proliferator‐activated receptor
Amanda N. Buerger, Melissa M. Heintz, Laurie C. Haws, Chad M. Thompson   +3 more
wiley   +1 more source

Integrated transcriptomic and metabolomic analyses reveal biphasic thermal adaptation strategies in <i>Lavandula angustifolia</i> under high-temperature stress. [PDF]

PeerJ
Tusong K, Liu Z.
europepmc   +1 more source