Results 211 to 220 of about 6,867,240 (296)

The structure of intact and active Photosystem II from Arabidopsis thaliana at 2.44 Å resolution. [PDF]

New Phytol
Forsman J, Graça AT, Aydin AO, Hall M, Hussein R, Schröder WP, Messinger J.   +6 more
europepmc   +1 more source

Protective Effects of Riociguat Against Contrast‐Induced Nephropathy: An Experimental and Machine Learning‐Based Study in Rats

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Contrast‐induced nephropathy (CIN) is an important cause of acute kidney injury following exposure to iodinated contrast media, and effective preventive strategies remain limited. This study investigated the renoprotective effects of riociguat, a soluble guanylate cyclase stimulator, in an experimental rat model of CIN and explored machine ...
Mustafa Begenc Tascanov, Kenan Toprak, Sibel Turedi, İsmail Koyuncu, Zulkif Tanrıverdi, Necip Fazıl Dedeoglu, Halil Fedai, Asuman Bicer, İbrahim Halil Altıparmak, Recep Demirbag, Gencay Sarıısık   +10 more
wiley   +1 more source

Phospholipid-driven conformational switching of HCV NS5A links protein folding to replication membrane remodeling. [PDF]

Sci Adv
Bulankina AV, Richter RM, Nettles JH, Yamane D, Grimm C, Karami Y, Stanton RA, Introini B, Hermann J, Charif H, König MS, Stroß C, Ortiz C, Kraus N, Wood D, Galceran F, Abele R, Maigret B, Schinazi RF, Zeuzem S, Biondi RM, Yi M, Tampé R, Kudryashev M, Welsch C.   +24 more
europepmc   +1 more source

Early Dapagliflozin and Melatonin Treatment Ameliorated LV Fibrosis via Suppressing TGF‐β1/Smads and Activating Nrf2‐ARE Signaling in MI Rodent

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study tested whether combined dapagliflozin (DAPA) and melatonin (Mel) therapy was superior to merely one for ameliorating the left ventricular (LV) fibrosis/remodeling and improving LV ejection fraction (LVEF) in rats after acute myocardial infarction (AMI). In vitro study demonstrated that DAPA treatment significantly suppressed the TGF‐
Jiunn‐Jye Sheu, Jui‐Ning Yeh, Han‐Tan Chai, John Y. Chiang, Chi‐Ruei Huang, Jun Guo, Hon‐Kan Yip   +6 more
wiley   +1 more source

Alterations in MicroRNA and Cytokine Expressions in Placental and Amniotic Tissues of COVID‐19 Affected Pregnant Women

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Since 2019, coronavirus disease 2019 (COVID‐19) has been associated with increased risks of preterm birth and placental complications. We prospectively investigated alterations in microRNAs (miRNAs) and cytokines in placental and amniotic tissues from pregnant women with and without COVID‐19 to evaluate the infection's impact on pregnancy ...
Wei‐Chun Chen, Shu‐Yu Hu, Chao‐Min Cheng, Ching‐Ju Shen   +3 more
wiley   +1 more source

Risk Factors Influencing Efficacy and Prognosis Evaluation of Neoadjuvant Systemic Therapy in Triple‐Positive Breast Cancer

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT To identify the determinants of the response to neoadjuvant systemic therapy (NST) in triple‐positive breast cancer (TPBC), we retrospectively enrolled 520 patients with human epidermal growth factor receptor 2 (HER2)‐positive breast cancer who were treated at The First Affiliated Hospital of Chongqing Medical University between January 2015 ...
Lin‐Rui Miao, Hao Liu, Hai‐Ying Yu, Jian Chen, Ming‐Yu Yang, Ya‐Lan Zhang, Gang Tu, Ling‐Feng Tang   +7 more
wiley   +1 more source

Indirect Striatal Projection Neurons Drive a D2 Receptor‐Dependent Pathway to Dyskinesia and Dystonia

Movement Disorders, EarlyView.
D2 receptor ablation in indirect‐pathway striatal neurons reduces or abolishes dyskinetic and dystonic behaviors induced by L‐DOPA or D2 receptor agonists, respectively. Contralateral turning is reduced, while forward locomotion is increased. These effects are associated with modulation of neuronal activity in dorsal striatum and external globus ...
Laura Andreoli, Teodor Nyman, Elena Espa, Johan Jakobsson, Osama F. Elabi, Maria Angela Cenci   +5 more
wiley   +1 more source

HC-HA/PTX3 from amniotic membrane reprograms human corneal fibroblasts to neural crest progenitors by switching from canonical to noncanonical TGFβ signaling. [PDF]

Stem Cell Res Ther
Zhu YT, Tighe S, Zhang Y, Helman A, Tseng SCG.   +4 more
europepmc   +1 more source

Trapped in the web: network architectures spread coevolution and shape adaptation

Oikos, EarlyView.
Adaptation is critical for biodiversity to persist under global change. Within ecological communities, species often face tradeoffs between adapting to shifting abiotic conditions and navigating the complex selective pressures imposed by interaction networks.
Alexandre Fuster‐ Calvo, Cecilia S. Andreazzi, Christine Parent, François Massol, Paulo R. Guimarães Jr, Dominique Gravel   +5 more
wiley   +1 more source

Therapeutic targeting of adhesion GPCRs: a status update and future potential. [PDF]

Expert Opin Drug Discov
Stillwell JD, Elmi MA, Parag RR, Van Meir EG.   +3 more
europepmc   +1 more source