Results 221 to 230 of about 254,547 (258)

Protein kinase D1: a protein of emerging translational interest

Frontiers in Bioscience, 2007
Protein kinases are of particular interest in treatment of human diseases because of their enzymatic activity and susceptibility to successful therapeutic targeting. Protein kinase D1 (PKD1), cloned from humans and mouse by two different groups and reported simultaneously in 1990s, is emerging as a protein of translational value.
Meena, Jaggi, Cheng, Du, Wenguang, Zhang, Kethandapatti C, Balaji   +3 more
openaire   +2 more sources

D1′—a New Member of D1 Protein Family in Cyanobacteria

2013
The D1 protein of Photosystem II (PSII), encoded by the psbA genes, is an indispensable component of oxygenic photosynthesis. Due to strongly oxidative chemistry of PSII water splitting, the D1 protein is prone to constant photodamage requiring its replacement, whereas most of the other PSII subunits remain ordinarily undamaged.
Ciprian Chis, Abdulah Mahboob, Sergey Vassilieev, Adriana Bica, Loredana Peca, Doug Brouce, Eva-Mari Aro, Cosmin Ionel Sicora   +7 more
openaire   +1 more source

D1-D2 protein degradation in the chloroplast

European Journal of Biochemistry, 1999
The D1 and D2 proteins of the photosystem II (PSII) reaction center are stable in the dark, while rapid degradation occurs in the light. Thus far, a quantitative correlation between degradation and photon fluences has not been determined. In Spirodela oligorrhiza, D1‐D2 degradation increases with photon flux.
Jansen, M.A.K., Mattoo, A.K., Edelman, M.   +2 more
openaire   +4 more sources

Protein kinase D1 inhibition interferes with mitosis progression

Journal of Cellular Physiology, 2019
AbstractProtein kinase D1 (PKD1) plays a vital role in signal transduction, cell proliferation, membrane trafficking, and cancer; however, the majority of the studies up to date had centered primarily on PKD1 functions in interphase, very little is known about its role during cell division.
Eduardo Martínez-León, Gastón Amable, Rodrigo Jácamo, María Elisa Picco, Laura Anaya, Enrique Rozengurt, Osvaldo Rey   +6 more
openaire   +3 more sources

Cyclin D1 and retinoblastoma protein expression in Kaposi's sarcoma

Journal of Cutaneous Pathology, 1997
Cyclins are implicated in the induction and control of the cell cycle. Cyclin D1 regulates G1‐phase progression by phosphorylation of the retinoblastoma protein (pRb). The Kaposi's sarcoma‐associated herpesvirus/human herpesvirus 8 (KSHV) contains and transcribes an open reading frame with sequence similarities to cellular D‐type cyclins.
M G, Horenstein, E, Cesarman, X, Wang, I, Linkov, V G, Prieto, D C, Louie   +5 more
openaire   +2 more sources

D1-protein dynamics in photosystem II: the lingering enigma

Photosynthesis Research, 2008
The D1/D2 heterodimer core is the heart of the photosystem II reaction center. A characteristic feature of this heterodimer is the differentially rapid, light-dependent degradation of the D1 protein. The D1 protein is possibly the most researched photosynthetic polypeptide, with aspects of structure-function, gene, messenger and protein regulation ...
Marvin, Edelman, Autar K, Mattoo
openaire   +2 more sources

The D1 and D2 Core Proteins

2005
In 1977, Chua and Gillham (J Cell Biology 74: 441–452) reported for the first time the existence of two chloroplast-encoded proteins within the thylakoid membrane of the green alga Chlamydomonas reinhardtii, which they termed D-l and D-2. The D1 and D2 proteins are now recognized as the Photosystem II reaction center polypeptides with a key role in ...
Peter J. Nixon, Mary Sarcina, Bruce A. Diner   +2 more
openaire   +1 more source

1-Butanol interferes with phospholipase D1 and protein kinase Cα association and inhibits phospholipase D1 basal activity

Biochemical and Biophysical Research Communications, 2005
1-Butanol is commonly used as a substrate for phospholipase D (PLD) activity measurement. Surprisingly we found that, in the presence of 30 mM 1-butanol (standard PLD assay conditions), PLD1 activity in COS-7 cells was lost after incubation for 2 min.
Tianhui, Hu, John H, Exton
openaire   +2 more sources

Protein Kinase D1 deletion ameliorates collage-induced arthritis

The Journal of Immunology, 2018
Abstract Although the etiology of Rheumatoid arthritis (RA) is unknown, it is thought that TLR signaling may be involved in the initiation and progression of the disease. Disruption of the TLR signaling at early stages of RA could be a possible therapeutic strategy.
Taewon Yoon, Hongsik Cho, John M Stuart, Ae-Kyung Yi   +3 more
openaire   +1 more source

Cyclin D1 protein expression and function in human breast cancer

International Journal of Cancer, 1994
AbstractCyclin D1 is a cell‐cycle regulator essential for G1, phase progression and a candidate proto‐oncogene implicated in pathogenesis of several human tumour types, including breast carcinomas. In spite of the accumulating genetic evidence, however, there are no data regarding abundance and properties of the cyclin D1 protein in breast cancer.
J, Bartkova, J, Lukas, H, Müller, D, Lützhøft, M, Strauss, J, Bartek   +5 more
openaire   +2 more sources