Results 31 to 40 of about 254,547 (258)

Regulation of Cardiac Stress Signaling by Protein Kinase D1 [PDF]

Molecular and Cellular Biology, 2006
In response to pathological stresses such as hypertension or myocardial infarction, the heart undergoes a remodeling process that is associated with myocyte hypertrophy, myocyte death, and fibrosis. Histone deacetylase 5 (HDAC5) is a transcriptional repressor of cardiac remodeling that is subject to phosphorylation-dependent neutralization in response ...
Brooke C, Harrison, Mi-Sung, Kim, Eva, van Rooij, Craig F, Plato, Philip J, Papst, Rick B, Vega, John A, McAnally, James A, Richardson, Rhonda, Bassel-Duby, Eric N, Olson, Timothy A, McKinsey   +10 more
openaire   +2 more sources

ATP and light regulate D1 protein modification and degradation Role of D1* in photoinhibition

FEBS Letters, 1992
We have recently shown that during in vivo photoinhibition the D1 protein is degraded via a modified form, designated D1*. Depending on light conditions, the amount of D1* varies in leaves between 0 and 50% of total D1 content. By isolating thylakoids from leaves acclimated to different light levels, and performing photoinhibition experiments on these ...
Aro, Eva-Mari, Kettunen, Reetta, Tyystjärvi, Esa   +2 more
openaire   +2 more sources

Oligomycin induced the proteasomal degradation of cyclin D1 protein [PDF]

The Journal of Antibiotics, 2009
We searched for compounds that affect the cyclin D1/retinoblastoma protein pathway from the in-house natural product library using a recombinant adenovirus with the Cre/loxP-regulated cyclin D1 overexpression system, and we found that oligomycin inhibited cell growth more effectively in cyclin D1-overexpressing SW480 cells than in control SW480 cells ...
Mai, Kanai, Satoru, Iba, Ryoko, Okada, Etsu, Tashiro, Masaya, Imoto   +4 more
openaire   +2 more sources

Cyclin D1 Protein Tissue Detection in Laryngeal Cancer

ORL, 2005
Cyclin D1 (CCND1) is a set of periodic regulatory proteins that is believed to govern cell cycle transit from G1 into S phase. Overexpression of CCND1 leads to abnormal cellular proliferation which underlies processes of tumorigenesis; CCND1 can thus function as a cooperative oncogene in cell transformation.
Segas, JV, Lazaris, AC, Nikolopoulos, TP, Kavantzas, NG, Lendari, IE, Tzagkaroulakis, AM, Patsouris, ES, Ferekidis, EA   +7 more
openaire   +3 more sources

The dopamine D1 receptor is expressed and induces CREB phosphorylation and MUC5AC expression in human airway epithelium

Respiratory Research, 2018
Background Dopamine receptors comprise two subgroups, Gs protein-coupled “D1-like” receptors (D1, D5) and Gi-coupled “D2-like” receptors (D2, D3, D4). In airways, both dopamine D1 and D2 receptors are expressed on airway smooth muscle and regulate airway
Nao Matsuyama, Sumire Shibata, Atsuko Matoba, Tada-aki Kudo, Jennifer Danielsson, Atsushi Kohjitani, Eiji Masaki, Charles W. Emala, Kentaro Mizuta   +8 more
doaj   +1 more source

Cyclin D1 overexpression and poor clinical outcomes in Taiwanese oral cavity squamous cell carcinoma

World Journal of Surgical Oncology, 2012
Background Cyclin D1 gene regulates cell cycle and plays an important role in the tumorigenesis of human cancers. The association between cyclin D1, clinicopathologic parameters and prognosis in oral cavity squamous cell carcinoma (OSCC) is inconclusive.
Huang Shiang-Fu, Cheng Sou-De, Chuang Wen-Yu, Chen I-How, Liao Chun-Ta, Wang Hung-Ming, Hsieh Ling-Ling   +6 more
doaj   +1 more source

Extracts from Sageretia thea reduce cell viability through inducing cyclin D1 proteasomal degradation and HO-1 expression in human colorectal cancer cells

BMC Complementary and Alternative Medicine, 2019
Background Sageretia thea (S. thea) has been used as the medicinal plant for treating hepatitis and fevers in Korea and China. Recently, anticancer activity of S. thea has been reported, but the potential mechanism for the anti-cancer property of S. thea
Ha Na Kim, Gwang Hun Park, Su Bin Park, Jeong Dong Kim, Hyun Ji Eo, Ho-Jun Son, Jeong Ho Song, Jin Boo Jeong   +7 more
doaj   +1 more source

Mechanism of Persistent Protein Kinase D1 Translocation and Activation [PDF]

Developmental Cell, 2003
The specificity of many signal transduction pathways relies on the spatiotemporal features of each signaling step. G protein-coupled receptor-mediated activation of protein kinases leads to diverse cellular effects. Upon receptor activation, PKD1 and several C-type protein kinases (PKCs), translocate to the plasma membrane and become catalytically ...
Oancea, Elena, Bezzerides, Vassilios J., Greka, Anna, Clapham, David E.   +3 more
openaire   +2 more sources

CCND1 copy number increase and cyclin D1 expression in acral melanoma: a comparative study of fluorescence in situ hybridization and immunohistochemistry in a Chinese cohort

Diagnostic Pathology, 2021
Background CCND1 copy number increase is characteristic of acral melanoma and is useful in distinguishing benign and malignant acral melanocytic lesions. Increase of the gene copy number may result in protein overexpression.
Jianying Liu, Wenjuan Yu, Fei Gao, Shuangshuang Qi, Juan Du, Xiaolong Ma, Yan Zhang, Jie Zheng, Jing Su   +8 more
doaj   +1 more source

Protein Kinase D1: A New Component in TLR9 Signaling [PDF]

The Journal of Immunology, 2008
AbstractProtein kinase D1 (PKD1) is expressed ubiquitously and regulates diverse cellular processes such as oxidative stress, gene expression, cell survival, and vesicle trafficking. However, the presence and function of PKD1 in monocytic cells are currently unknown.
Jeoung-Eun, Park, Young-In, Kim, Ae-Kyung, Yi   +2 more
openaire   +2 more sources