Results 41 to 50 of about 254,547 (258)

Dr. Autar Krishen Mattoo (1943-2024): an outstanding plant biologist with a focus on photosynthesis

Photosynthetica
We provide here the academic life of Dr. Autar Krishen Mattoo (1943-2024), including his role as a research leader at the United States Department of Agriculture and his outstanding contributions in photosynthesis, plant physiology and molecular biology ...
A.K. HANDA, M. EDELMAN, W.W. ADAMS III, G. GOVINDJEE   +3 more
doaj   +1 more source

Ethanol extracts from the branch of Taxillus yadoriki parasitic to Neolitsea sericea induces cyclin D1 proteasomal degradation through cyclin D1 nuclear export

BMC Complementary and Alternative Medicine, 2018
Background Although the inhibitory effect of mistletoe on cancer cell growth has been reported, the underlying mechanisms to explain its anti-proliferative activity are not fully studied.
Su Bin Park, Gwang Hun Park, Ha Na Kim, Hun Min Song, Ho-Jun Son, Ji Ae Park, Hyun-Seok Kim, Jin Boo Jeong   +7 more
doaj   +1 more source

Pancreatic oncogenic signaling cascades converge at Protein Kinase D1 [PDF]

Cell Cycle, 2015
Although over 95% of pancreatic ductal adenocarcinoma (PDA) harbor Kras mutations, the presence of an oncogenic allele of Kras alone is not sufficient to develop pancreatic cancer. Moreover, mutant Kras is not constitutively-active per se,1 and requires additional stimulation to initiate a feed forward loop for enhanced pathological level of activity.2
Geou-Yarh, Liou, Michael, Leitges, Peter, Storz   +2 more
openaire   +2 more sources

Modulation of catalytic activity in multi-domain protein tyrosine phosphatases. [PDF]

PLoS ONE, 2011
Signaling mechanisms involving protein tyrosine phosphatases govern several cellular and developmental processes. These enzymes are regulated by several mechanisms which include variation in the catalytic turnover rate based on redox stimuli, subcellular
Lalima L Madan, S Veeranna, Khader Shameer, Chilamakuri C S Reddy, R Sowdhamini, B Gopal   +5 more
doaj   +1 more source

Mitochondrial diacylglycerol initiates protein-kinase-D1-mediated ROS signaling [PDF]

Journal of Cell Science, 2009
Increases in reactive oxygen species (ROS) have been implicated in age-related diseases, including cancer. The serine/threonine kinase protein kinase D1 (PKD1) is a stress-responsive kinase and sensor for reactive oxygen species, which can initiate cell survival through NF-κB signaling.
Catherine F, Cowell, Heike, Döppler, Irene K, Yan, Angelika, Hausser, Yoshio, Umezawa, Peter, Storz   +5 more
openaire   +2 more sources

Protein kinase D1 deficiency promotes differentiation in epidermal keratinocytes [PDF]

Journal of Dermatological Science, 2014
Protein kinase D (PKD or PKD1) is a serine/threonine protein kinase that has been shown to play a role in a variety of cellular processes; however, the function of PKD1 in the skin has not been fully investigated. The balance between proliferation and differentiation processes in the predominant cells of the epidermis, the keratinocytes, is essential ...
Vivek, Choudhary, Lawrence O, Olala, Ismail, Kaddour-Djebbar, Inas, Helwa, Wendy B, Bollag   +4 more
openaire   +2 more sources

Upregulation of NPL4 promotes bladder cancer cell proliferation by inhibiting DXO destabilization of cyclin D1 mRNA

Cancer Cell International, 2019
Background NPL4 is an important cofactor of the valosin-containing protein (VCP)–NPL4–UFD1 complex. The VCP–NPL4–UFD1 has been considered as a ubiquitin proteasome system (UPS) regulator and response to protein degradation.
Bao-Sai Lu, Yue-Wei Yin, Yan-Ping Zhang, Ping-Ying Guo, Wei Li, Kai-Long Liu   +5 more
doaj   +1 more source

Effects of dietary lipid-to-carbohydrate ratio on growth and carbohydrate metabolism in juvenile cobia (Rachycentron canadum)

Animal Nutrition, 2020
This experiment was conducted to investigate the effects of dietary lipid-to-carbohydrate ratio on growth and carbohydrate metabolism in juvenile cobia (Rachycentron canadum). Six isonitrogenous diets were prepared to vary in lipid-to-carbohydrate ratio (
Hongxia Zhao, Junming Cao, Xiaoying Chen, Guoxia Wang, Junru Hu, Bing Chen   +5 more
doaj   +1 more source

Cyclin D1 protein expression in mantle cell lymphoma

Annals of Oncology, 1995
The t(11;14)(q13;q32) is a chromosomal abnormality usually associated with mantle cell (centrocytic) lymphomas, although it has occasionally been reported in other chronic lymphoproliferative disorders such as chronic lymphocytic leukemia, prolymphocytic leukemia, splenic lymphoma with villous lymphocytes, and multiple myeloma. This abnormality results
S, Alkan, B, Schnitzer, J L, Thompson, L C, Moscinski, C W, Ross   +4 more
openaire   +2 more sources

Requirement of protein kinase D1 for pathological cardiac remodeling [PDF]

Proceedings of the National Academy of Sciences, 2008
The adult heart responds to biomechanical stress and neurohormonal signaling by hypertrophic growth, accompanied by fibrosis, diminished pump function, and activation of a fetal gene program. Class II histone deacetylases (HDACs) suppress stress-dependent remodeling of the heart via their association with the MEF2 transcription factor, an ...
Jens, Fielitz, Mi-Sung, Kim, John M, Shelton, Xiaoxia, Qi, Joseph A, Hill, James A, Richardson, Rhonda, Bassel-Duby, Eric N, Olson   +7 more
openaire   +2 more sources