Results 211 to 220 of about 219,305 (238)

Cutaneous Immunoreactivity of D2-40 Antibody Beyond the Lymphatics

The American Journal of Dermatopathology, 2007
Recent research suggests that the D2-40 monoclonal antibody recognizes the 40,000 Da O-linked sialoglycoprotein podoplanin. Podoplanin not only is highly expressed in lymphatic endothelium but also in other cell types, including sebaceous carcinoma cells. Using the D2-40 antibody, our purpose was to evaluate expression of podoplanin in sebaceous glands
Amal H A, Gomaa, Mina, Yaar, Jag, Bhawan
openaire   +2 more sources

D2-40 Expression in Primary Scarring and Nonscarring Alopecia

The American Journal of Dermatopathology, 2010
The pathogenesis of scarring alopecia is believed to be related to damage to stem cells within, and outside the confines of, the follicular bulge region. Scattered reports indicate that D2-40, a monoclonal antibody that specifically detects a fixation-resistant epitope on podoplanin, highlights the basal cell layer of the outer root sheath. Given this,
Meera, Mahalingam, Mai P, Hoang
openaire   +2 more sources

D2-40 Antibody is a Specific Marker for B2 Thymomas

Applied Immunohistochemistry & Molecular Morphology, 2017
The correlation between the worse outcome of thymomas and expression of podoplanin (D2-40 antibody) in neoplastic cells has been proved in recent studies. We investigated the expression of podoplanin in thymic epithelial tumors of different histologic types and stages resected in our institution.
Malgorzata, Szolkowska, Renata, Langfort, Sebastian, Winiarski, Piotr, Rudzinski, Dorota, Giedronowicz, Ewa, Szczepulska-Wojcik, Piotr, Ronduda, Beata, Maksymiuk, Tadeusz, Orlowski   +8 more
openaire   +2 more sources

Mucinous Carcinoma of the Skin: Evaluation of Lymphatic Invasion With D2-40

The American Journal of Dermatopathology, 2008
Primary cutaneous mucinous carcinoma is a rare adnexal sweat gland neoplasm that mainly affects elderly people. Differential diagnosis includes mammary and gastrointestinal metastatic mucinous carcinoma (MC) and secondary cutaneous involvement by underlying neoplasms.
Sabela, Paradela, Iria, Castiñeiras, Jesús, Cuevas, Manuel, Almagro, Jesús, del Pozo, Eduardo, Fonseca   +5 more
openaire   +2 more sources

Diagnostic utility of D2‐40 and podoplanin in effusion cell blocks

Diagnostic Cytopathology, 2007
AbstractThe distinction between malignant mesothelioma and adenocarcinoma is a diagnostic challenge in cytologic specimens of effusion fluids. As for today, no single antibody has demonstrated absolute sensitivity or specificity for Mesothelioma. D2‐40 and podoplanin have recently been recognized to stain mesothelial cells.
Ritu, Bhalla, Momin T, Siddiqui, Daniza, Mandich, Richard W, Cartun, Mary D, Fiel-Gan, Aziza, Nassar, Srinivas R, Mandavilli   +6 more
openaire   +2 more sources

Cutaneous Keratocyst With D2-40 Immunoreactivity in Basal Cell Nevus Syndrome

The American Journal of Dermatopathology, 2021
Abstract: Although not a diagnostic criterion for basal cell nevus syndrome (BCNS, OMIM#109400), cutaneous cysts, particularly epidermoid cysts, are common in this condition. Cutaneous keratocysts, on the other hand, are extremely rare in general and have been identified in only 5 patients with BCNS.
Clare A, Goggins, Michele L, Zerah, Florencia, Anatelli, Scott A, Norton   +3 more
openaire   +2 more sources

Immunohistochemical demonstration of D2‐40 in basal cell carcinomas of the skin

Journal of Cutaneous Pathology, 2008
Background:  Recently, immunoreactivity to D2‐40, a monoclonal antibody to lymphatic endothelium, was shown in a subgroup of epidermal basal cells and the majority of squamous cell carcinomas, but the immunoreactivity to this antibody has not been examined in basal cell carcinomas (BCCs) of the skin.Methods:  Expression of D2‐40 was analyzed together ...
Mitsuaki, Ishida, Ryoji, Kushima, Hidetoshi, Okabe   +2 more
openaire   +2 more sources

Significance of D2-40 expression in the diagnosis of gastrointestinal stromal tumor

Medical Molecular Morphology, 2008
We incidentally found the expression of D2-40 in Cajal interstitial cells for the immunohistochemical valuation of lymphatic invasion by gastric and colonic cancer cells. Therefore, we suggested that D2-40 might become an available marker for gastrointestinal stromal tumors (GISTs).
Naoto, Kuroda, Nobuyuki, Tanida, Kazuhisa, Oonishi, Kaori, Inoue, Masahiko, Ohara, Keiko, Mizuno, Takahiro, Taguchi, Yoshihiro, Hayashi, Kazuhiro, Hanazaki, Gang-Hong, Lee   +9 more
openaire   +2 more sources

Expression of D2‐40 in adjunct diagnosis of papillary thyroid carcinoma

APMIS, 2007
The clinical pathologic criteria for nuclear features of papillary thyroid carcinoma are subjective and sometimes cannot distinguish carcinoma from adenomatous goiter and follicular neoplasms. No single antibody has demonstrated high sensitivity or specificity in making these distinctions.
Sheng-Lan, Wang, Shau-Hsuan, Li, Wan-Tzu, Chen, Chee-Yin, Chai   +3 more
openaire   +2 more sources

D2-40 immunoreactivity in penile squamous cell carcinoma: a marker of aggressiveness

Human Pathology, 2011
D2-40 immunohistochemical expression was investigated in tissue specimens from 39 patients with squamous cell carcinoma of the penis who underwent partial or total penectomy between 1987 and 2008. Patient age, tumor size, and grade; D2-40-positive lymphatic vessel density in intratumoral, peritumoral, and normal tissue; cell positivity for D2-40 in ...
Daniele, Minardi, Gianluca, d'Anzeo, Guendalina, Lucarini, Alessandra, Filosa, Antonio, Zizzi, Oriana, Simonetti, Massimo, Polito, Anna Maria, Offidani, Roberto, Di Primio, Rodolfo, Montironi, Giovanni, Muzzonigro   +10 more
openaire   +2 more sources