Clinical Usefulness of D2-40 in Non-Small Cell Lung Cancer
Lung, 2010D2-40 is a recently developed monoclonal antibody that reacts with a 40 kDa O-linked sialoglycoprotein and has been used for the assessment of lymphatic invasion in tumor specimens. We have evaluated the diagnostic usefulness of D2-40 and association of its immunopositivity with clinicopathological parameters in adenocarcinoma and squamous cell ...
Kyung Hoon, Min +8 more
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Expression of the lymphatic marker podoplanin (D2-40) in human fetal eyes
Experimental Eye Research, 2014During human ocular development, expression of proteins varies in different maturation stages. This study aims to characterize structures in human fetal eyes stained by the lymphatic marker podoplanin (D2-40) with emphasis on the stage of maturation and the presence of intraocular lymphatic structures.
Martina C, Herwig +6 more
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Retiform Hemangioendotheliomas Usually do not Express D2-40 and VEGFR-3
The American Journal of Dermatopathology, 2008Retiform hemangioendothelioma (RH) is a rare vascular neoplasm most often occurring in the limbs of middle-aged females. This entity is characterized by infiltrative vascular spaces arranged in a pattern similar to the rete testis. RH differs from angiosarcoma by lacking cytologic atypia and high mitotic rates.
Amy, Parsons +2 more
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Decreased D2-40 immunoreactivity in stored paraffin sections and methods for preserving it
Biotechnic & Histochemistry, 2014D2-40, a monoclonal antibody against podoplanin, is a selective marker of lymphatic endothelium and is widely used for research on and diagnosis of pathology of lymphatic vessels. We examined the relation between the duration of tissue section storage and changes in immunostaining by D2-40 antibody; we evaluated also the effects of preservation methods
T, Sasaki +9 more
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Detection of Lymphovascular Invasion by D2-40 (Podoplanin) Immunoexpression in Endometrial Cancer
International Journal of Gynecological Cancer, 2012Lymph node involvement is a major feature in tumor spread of endometrial cancer and predicts prognosis. Therefore, evaluation of lymph vessel invasion (LVI) in tumor tissue as a predictor for lymph node metastasis is of great importance. Immunostaining of D2-40 (podoplanin), a specific marker for lymphatic endothelial cells, might be able to increase ...
Sarah K, Weber +8 more
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D2-40 is Not a Specific Marker for Cells of Mesothelial Origin in Serous Effusions
American Journal of Surgical Pathology, 2006The presence of effusion in a patient with a history of primary malignant tumor elsewhere in the body is generally accepted as a clinical manifestation of metastatic disease. Even in those cases, it is sometimes difficult to differentiate reactive mesothelial cells from carcinoma cells.
Assia V, Bassarova +2 more
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Podoplanin (D2-40) is a Highly Effective Marker of Follicular Dendritic Cells
Applied Immunohistochemistry & Molecular Morphology, 2009The monoclonal antibody D2-40 recognizes the membrane protein podoplanin, which is an established marker for germ cell tumors, mesotheliomas, and other tumor types and is also expressed in a variety of normal cells including follicular dendritic cells (FDCs). To determine whether podoplanin represents an effective FDC marker for pathologic lymph nodes,
Derek K, Marsee +2 more
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D2‐40 highlights lymphatic vessel proliferation of angiolymphoid hyperplasia with eosinophilia
Journal of Cutaneous Pathology, 2009Angiolymphoid hyperplasia with eosinophilia (ALHE) is a benign, uncommon idiopathic condition, characterized by cutaneous papules or nodules, whose etiopathogenesis is still unclear. It has been considered an angioproliferating lesion (epithelioid hemangioma) since histologically it is marked by a proliferation of blood vessels, accompanied by an ...
M, Miteva +5 more
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Lymphangiogenesis in Crohn’s disease: an immunohistochemical study using monoclonal antibody D2-40
Virchows Archiv, 2007Crohn's disease (CD) is a chronic inflammatory bowel disorder of unknown etiology. An involvement of the intestinal lymphatic system has been suggested. Recently, monoclonal antibodies have become available to distinguish lymphatic vessels from blood vessels.
PEDICA, Federica +4 more
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Lymphatic vessels in human sural nerve: immunohistochemical detection by D2-40.
Lymphology, 2006Lymphatics were detected in the epineurium of the human sural nerve by D-240 immunostaining and confirmed by ultrastructural examination.
Volpi Nila +6 more
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