Results 31 to 40 of about 219,305 (238)
BMC Gastroenterology, 2010 Background From the morphological appearance, it was impossible to distinguish terminal portal venules from small lymphatic vessels in the portal tract even using histochemical microscopic techniques.
Yoshimura Kazunori +7 more
doaj +1 more source
Diagnostic Pathology, 2011 Background D2-40 has been shown a selective marker for lymphatic endothelium, but also shown in the benign cervical basal cells. However, the application of D2-40 immunoreactivity in the cervical basal cells for identifying the grade of cervical ...
Lu Zhouping +4 more
doaj +1 more source
Diagnostic Pathology, 2021 Background Lymphovascular invasion (VI) is an established prognostic marker for many cancers including bladder cancer. There is a paucity of data regarding whether the prognostic significance of lymphatic invasion (LVI) differs from blood vessel invasion
Birgitte Carlsen +3 more
doaj +1 more source
Utility of D2-40, a novel mesothelial marker, in the diagnosis of malignant mesothelioma [PDF]
Modern Pathology, 2005 Although immunohistochemistry has proven to be valuable in the differentiation of epithelioid mesothelioma from pulmonary or metastatic adenocarcinoma, no single antibody has demonstrated absolute sensitivity or specificity in making this distinction. Using immunohistochemical analysis with D2-40, a recently available monoclonal antibody that has been ...
Albert Y, Chu +4 more
openaire +2 more sources
BMC Oral Health, 2021 Background The aims of this study were to determine intra (ILVD) and peritumoral (PLVD) lymphatic vessel density (LVD), and to investigate the relationship of LVD with occult metastasis and prognosis.
Simone E. S. Faustino +6 more
doaj +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Podoplanin expression in various types of oral dysplasia and oral squamous cell carcinoma
Journal of Taibah University Medical Sciencesالملخص: أهداف البحث: تبحث هذه الدراسة دور البودوبلانين كواسم مرتبط بالتطور الخبيث والتقدم وضعف التكهن في طلاوة الفم وأشكال مختلفة من سرطان الخلايا الحرشفية الفموية، خاصة فيما يتعلق بمستوى الغزو. طرق البحث: أجري تحليل كيميائي نسيجي مناعي للبودوبلانين على
Fatemeh Mashhadiabbas, BDS, DDS +4 more
doaj +1 more source
Heterotropic regulation and negative homotropic cooperativity
FEBS Open Bio, EarlyView.We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea +5 more
wiley +1 more source
Utility of D2-40 Immunohistochemistry in Detecting Lymphovascular Invasion in Colorectal Carcinoma: A Cross-sectional Study [PDF]
National Journal of Laboratory MedicineIntroduction: The detection of Lymphovascular Invasion (LVI) has been recognised as an important prognostic factor in Colorectal Carcinoma (CRC), particularly in determining the adjuvant chemotherapy and further treatment plan.
Saswati Das +4 more
doaj +1 more source