Results 51 to 60 of about 24,286 (164)
We present a protocol to detect and characterize questionable backbone conformations in X‐ray protein structure models. These conformations may arise from artifacts related to the crystallization process or from errors introduced during model building and refinement.
Clémence Sarrau +5 more
wiley +1 more source
Vector and tensor perturbations in Horava-Lifshitz cosmology
We study cosmological vector and tensor perturbations in Horava-Lifshitz gravity, adopting the most general Sotiriou-Visser-Weinfurtner generalization without the detailed balance but with projectability condition.
Anzhong Wang +4 more
core +1 more source
On Models of New Physics for the Tevatron Top A_FB [PDF]
CDF has observed a top forward-backward asymmetry discrepant with the Standard Model prediction at 3.4 \sigma. We analyze models that could generate the asymmetry, including flavor-violating W's, horizontal Z'_Hs, triplet and sextet diquarks, and ...
Gresham, Moira I. +2 more
core +3 more sources
A surface‐entropy reduction approach for human Polo‐like kinase 1 (PLK1) enabled a reproducible and robust crystallization system for this cancer drug target. Co‐crystal structures with representatives of three different small‐molecule inhibitor classes were elucidated.
Uwe Eberspaecher +7 more
wiley +1 more source
Xtricorder is a tool for analysing crystallographic data, featuring a likelihood‐enhanced self‐rotation function and a novel `composite‐section diagram' thereof, which aids interpretation and enables a machine learning‐enhanced prediction of asymmetric unit content.Analysis of crystallographic diffraction data after collection and integration but ...
Airlie J. McCoy, Randy J. Read
wiley +1 more source
Completion of partial structures using Patterson maps with the CrysFormer machine‐learning model
We integrate existing machine learning‐based protein structure‐prediction methods with X‐ray crystallography by completing partial structures derived from AlphaFold predictions and the corresponding Patterson map information. The CrysFormer results are promising when applied to an initial data set of 15‐residue fragments in P21 unit cells.Protein ...
Tom Pan +4 more
wiley +1 more source
On mass limit for chiral color symmetry $G'$-boson from Tevatron data on $t \bar{t}$ production
The contributions of $G'$-boson predicted by the chiral color symmetry of quarks to the cross section $\sigma_{t\bar{t}}$ and to the forward-backward asymmetry $A_{\rm FB}^{p \bar p}$ of $t\bar{t}$ production at the Tevatron are calculated with account ...
Martynov, M. V., Smirnov, A. D.
core +1 more source
Reconstructing biological molecules with help from video gamers
The results of the Foldit citizen science puzzles for crystallographic models and their integration into the PDB‐REDO databank are discussed.Foldit is a citizen science video game in which players tackle a variety of complex biochemistry puzzles. Here, we describe a new series of puzzles in which Foldit players improve the accuracy of models in the ...
Andreas C. Petrides +4 more
wiley +1 more source
Non-Gaussianity Consistency Relation for Multi-field Inflation
While detection of the "local form" bispectrum of primordial perturbations would rule out all single-field inflation models, multi-field models would still be allowed.
A. A. Starobinsky +7 more
core +1 more source
Cryo‐EM single‐particle analysis expanding towards increasingly native samples
Cryo‐EM single‐particle analysis has revolutionized structural biology by allowing high‐resolution analysis of large molecular assemblies that are not amenable to crystallography or NMR. Combination of this technology with innovative sample‐preparation protocols further expands the range of potential targets.The explosion of cryo‐electron microscopy ...
Jonas Moecking, Tzviya Zeev-Ben-Mordehai
wiley +1 more source

