Results 11 to 20 of about 1,429 (166)

Clinical and Pharmacological Investigation of Myotoxicity in Sri Lankan Russell's Viper (Daboia russelii) Envenoming. [PDF]

PLoS Neglected Tropical Diseases, 2016
BackgroundSri Lankan Russell's viper (Daboia russelii) envenoming is reported to cause myotoxicity and neurotoxicity, which are different to the effects of envenoming by most other populations of Russell's vipers. This study aimed to investigate evidence
Anjana Silva, Christopher Johnston, Sanjaya Kuruppu, Daniela Kneisz, Kalana Maduwage, Oded Kleifeld, A Ian Smith, Sisira Siribaddana, Nicholas A Buckley, Wayne C Hodgson, Geoffrey K Isbister   +10 more
doaj   +10 more sources

Early identification of acute kidney injury in Russell's viper (Daboia russelii) envenoming using renal biomarkers. [PDF]

PLoS Neglected Tropical Diseases, 2019
BackgroundAcute kidney injury (AKI) is a major complication of snake envenoming, but early diagnosis remains problematic. We aimed to investigate the time course of novel renal biomarkers in AKI following Russell's viper (Daboia russelii) bites ...
Indira Ratnayake, Fahim Mohamed, Nicholas A Buckley, Indika B Gawarammana, Dhammika M Dissanayake, Umesh Chathuranga, Mahesh Munasinghe, Kalana Maduwage, Shaluka Jayamanne, Zoltan H Endre, Geoffrey K Isbister   +10 more
doaj   +4 more sources

Anti-Snake Venom Potential of Clerodendrum serratum Extracts on Bungarus caeruleus and Daboia russelii Venom

Bangladesh Journal of Pharmacology, 2018
Anti-snake venom therapy is the only treatment for snake bite but leads to acute and chronic conditions which may be severe. The medicinal plants have gained importance over years to find an effective alternative to anti-snake venom.
Sunil S More, Swetha Vasudev
exaly   +4 more sources

A randomized controlled trial of fresh frozen plasma for coagulopathy in Russell's viper (Daboia russelii) envenoming. [PDF]

J Thromb Haemost, 2017
Essentials Russell's viper envenoming is a major health issue in South Asia and causes coagulopathy. We studied the effect of fresh frozen plasma and two antivenom doses on correcting coagulopathy. Fresh frozen plasma did not hasten recovery of coagulopathy.
Isbister GK, Jayamanne S, Mohamed F, Dawson AH, Maduwage K, Gawarammana I, Lalloo DG, de Silva HJ, Scorgie FE, Lincz LF, Buckley NA.   +10 more
europepmc   +9 more sources

Synergistically acting PLA2: Peptide hemorrhagic complex from Daboia russelii venom [PDF]

Toxicon, 2013
Snake venoms are complex mixture of enzymatic and non-enzymatic proteins. Non-covalent protein–protein interaction leads to protein complexes, which bring about enhanced pharmacological injuries by their synergistic action. Here we report identification and characterization of a new Daboia russelii hemorrhagic complex I (DR–HC-I) containing ...
Venkatesh, M., Veerabasappa Gowda, T.
openaire   +3 more sources

Unveiling the nanotoxicology of snake venoms through functional and biochemical characterization of extracellular vesicles from Naja naja and Daboia russelii [PDF]

Scientific Reports
Snake venom is a complex biochemical arsenal that exerts multifaceted effects on host physiology, primarily targeting the hemostatic, cellular, and metabolic systems.
Nagendra K, Shankar M. Bakkannavar, Vinutha R. Bhat, Freston Marc Sirur   +3 more
doaj   +2 more sources

A proteomic analysis of Pakistan Daboia russelii russelii venom and assessment of potency of Indian polyvalent and monovalent antivenom

Journal of Proteomics, 2016
To address the dearth of knowledge on the biochemical composition of Pakistan Russell's Viper (Daboia russelii russelii) venom (RVV), the venom proteome has been analyzed and several biochemical and pharmacological properties of the venom were investigated.
Ashis K, Mukherjee, Bhargab, Kalita, Stephen P, Mackessy   +2 more
openaire   +3 more sources

Preclinical evaluation of small molecule inhibitors as early intervention therapeutics against Russell’s viper envenoming in India [PDF]

Communications Medicine
Background Snakebites are problematic in many developing regions, including India, where over half of global snakebite deaths occur. Antivenoms are currently the only licensed treatment for snakebites.
Gotravalli V. Rudresha, Suyog Khochare, Nicholas R. Casewell, Kartik Sunagar   +3 more
doaj   +2 more sources

Neutralization of systemic toxicity of Daboia russelii venom and reprotoxin fraction by IgY antibodies

Medicine in Drug Discovery
Daboia russelii, a highly venomous snake prevalent in South Asia, causes significant morbidity and mortality due to its complex venom, which includes neurotoxins, hemotoxins, and reprotoxins.
Punithkumar Naraganahalli Krishnaraj, Kiran Kumar Mudnakudu-Nagaraju, Nagalambika Prasad, Chandavi Venkatesh, Deekshith Ramesh, Druthi Venktesh, Anusha Chikkamandagere Kumar, Kumar Jajur Ramanna   +7 more
doaj   +2 more sources

Daboxin P, a Major Phospholipase A2 Enzyme from the Indian Daboia russelii russelii Venom Targets Factor X and Factor Xa for Its Anticoagulant Activity. [PDF]

PLoS ONE, 2016
In the present study a major protein has been purified from the venom of Indian Daboia russelii russelii using gel filtration, ion exchange and Rp-HPLC techniques.
Maitreyee Sharma, Janaki Krishnamurthy Iyer, Norrapat Shih, Munmi Majumder, Venkata Satish Kumar Mattaparthi, Rupak Mukhopadhyay, Robin Doley   +6 more
doaj   +2 more sources