Results 21 to 30 of about 1,429 (166)

Integrated computational investigation of Glycosmis pentaphylla-derived compounds against major venom proteins of Daboia russelii [PDF]

Frontiers in Molecular Biosciences
Snakebite envenomation remains a significant neglected tropical disease, particularly in South Asia, where Daboia russelii (Russell’s viper) causes substantial morbidity and mortality.
Sana S. Hussain, Danie J. Kingsley
doaj   +2 more sources

Characterization of a Kunitz-type protease inhibitor peptide (Rusvikunin) purified from Daboia russelii russelii venom

International Journal of Biological Macromolecules, 2014
The snake venom may be considered as a potent source of untapped therapeutic proteins and peptides. The peptide mass fingerprinting and N-terminal sequence alignment of a 6.9kDa peptide named Rusvikunin from Daboia russelii russelii venom show the presence of putative conserved domains of the KU superfamily.
Ashis K, Mukherjee, Stephen P, Mackessy, Sumita, Dutta   +2 more
openaire   +3 more sources

Antibacterial potential of a basic phospholipase A₂(VRV-PL-VIIIa) from Daboia russelii pulchella (Russell's viper) venom [PDF]

Journal of Venomous Animals and Toxins including Tropical Diseases, 2015
Background:Microbial/bacterial resistance against antibiotics poses a serious threat to public health. Furthermore, the side effects of these antibiotics have stimulated tremendous interest in developing new molecules from diverse organisms as ...
Shivalingaiah Sudharshan, Bhadrapura Lakkappa Dhananjaya   +1 more
doaj   +2 more sources

From Venom to Kidney Injury: A Critical Review of Daboia siamensis Envenoming [PDF]

Toxins
Acute kidney injury (AKI) is a severe complication of Eastern Russell’s viper (Daboia siamensis) envenoming, but species-specific mechanisms, treatment effects, and long-term outcomes remain uncertain.
Ren-Chieh Wu, Kuang-Ting Yeh
doaj   +2 more sources

Hiss and tell: What influences venom yields of India's big four snakes? [PDF]

PLoS Neglected Tropical Diseases
Snake venoms have evolved over millions of years to subdue prey and deter predators rapidly. The potency and amount of venom differ both within and across species, and are primarily influenced by their ecology and environment.
Prasad Gopalkrishna Gond, Mihir Kumar, Ajinkya Unawane, Kartik Sunagar   +3 more
doaj   +2 more sources

Population Pharmacokinetics of an Indian F(ab')2 Snake Antivenom in Patients with Russell's Viper (Daboia russelii) Bites. [PDF]

PLoS Neglected Tropical Diseases, 2015
There is limited information on antivenom pharmacokinetics. This study aimed to investigate the pharmacokinetics of an Indian snake antivenom in humans with Russell's viper bites.Patient data and serial blood samples were collected from patients with ...
Geoffrey K Isbister, Kalana Maduwage, Ana Saiao, Nicholas A Buckley, Shaluka F Jayamanne, Shahmy Seyed, Fahim Mohamed, Umesh Chathuranga, Alexandre Mendes, Chandana Abeysinghe, Harindra Karunathilake, Indika Gawarammana, David G Lalloo, H Janaka de Silva   +13 more
doaj   +2 more sources

Pulmonary hemorrhage and the management following Russell’s viper (Daboia russelii) envenoming in Sri Lanka [PDF]

Asia Pacific Journal of Medical Toxicology, 2020
Background: Patients presenting to Emergency department following consumption of toxic substances is not an uncommon phenomenon globally. It becomes essential for the Emergency physicians to have in-depth knowledge of all the toxic products available in ...
R.M.M.K.Namal Rathnayaka, P.E.A.Nishanthi Ranathunga, S.A.M. Kularatne   +2 more
doaj   +2 more sources

Elucidation of procoagulant mechanism and pathophysiological significance of a new prothrombin activating metalloprotease purified from Daboia russelii russelii venom

Toxicon, 2015
The procoagulant proteases present in Russell's Viper venom (RVV) are responsible for promoting consumption coagulopathy in victims. In this study, a procoagulant metalloprotease (Rusviprotease) possessing prothrombin activating and α-fibrinogenase properties has been purified and characterized from RVV.
Rupamoni, Thakur, Pronobesh, Chattopadhyay, Siddharth S, Ghosh, Ashis K, Mukherjee   +3 more
openaire   +3 more sources

Taxon-selective venom variation in adult and neonate Daboia russelii (Russell's Viper), and antivenom efficacy [PDF]

Toxicon, 2022
Major variations in venom composition can occur between juvenile and adult venomous snakes. However, due to logistical constraints, antivenoms are produced using adult venoms in immunising mixtures, possibly resulting in limited neutralisation of juvenile snake venoms.
Christina N. Zdenek, Abhinandan Chowdhury, Grace Y.H. Haw, Aude Violette, Rudy Fourmy, Thomas Christ, Freek J. Vonk, Bryan G. Fry   +7 more
openaire   +5 more sources

Revisiting Russell's viper (Daboia russelii) bite in Sri Lanka: is abdominal pain an early feature of systemic envenoming? [PDF]

PLoS ONE, 2014
The Russell's viper (Daboia russelii) is responsible for 30-40% of all snakebites and the most number of life-threatening bites of any snake in Sri Lanka.
Senanayake A M Kularatne, Anjana Silva, Kosala Weerakoon, Kalana Maduwage, Chamara Walathara, Ranjith Paranagama, Suresh Mendis   +6 more
doaj   +2 more sources