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Synthesis of [3,4,8-13C3]daidzein

Tetrahedron, 2004
Abstract The biological effects of the soy isoflavones have attracted considerable interest in recent years leading to numerous studies on dietary intake and epidemiology. Such studies require accurate and reproducible analytical methods. Herein we report the first synthesis of a multiply 13C-labelled daidzein derivative, [3,4,8-13C3]daidzein, which ...
Mark F Oldfield   +2 more
openaire   +1 more source

The synthesis of daidzein sulfates

Tetrahedron, 2003
The first syntheses of the urinary isoflavone metabolites, daidzein 4'-sulfate, daidzein 7-sulfate and daidzein 4',7-disulfate are described. These syntheses employ a key protecting group strategy, allowing regiospecific sulfation.
Fairley, Brian   +2 more
openaire   +2 more sources

Synthesis of 13C labelled daidzein and formononetin

Bioorganic & Medicinal Chemistry Letters, 1998
Efficient methods are described for the synthesis of daidzein and formononetin labelled with a single 13C atom at the 4-position, to prepare material for metabolic studies.
J L, Whalley, T J, Bond, N P, Botting
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Daidzein improves insulin resistance in ovariectomized rats

Climacteric, 2012
To determine whether daidzein improves insulin resistance by modifying weight gain, visceral fat accumulation, blood lipids and serum cytokines levels in ovariectomized Sprague-Dawley rats.Twenty-eight 12-week-old female rats were divided into three groups: the sham-operated group (SHAM) (n =10), the ovariectomized group receiving daidzein therapy ...
Y K, Cao, S F, Zhang, S E, Zou, X, Xia
openaire   +2 more sources

Daidzein-imprinted membranes using co-functional monomers

Journal of Chromatography A, 2009
Daidzein-imprinted poly(methacrylamide-co-acrylic acid) composite membranes with different ratios of methacrylamide (MAM) versus acrylic acid (AA) were prepared via UV initiated photo-copolymerization on the commercial filter paper with ethylene glycol dimethacrylate (EGDMA) as cross-linker and mixed cellulose ester as agglutinant.
Ping, Wang   +3 more
openaire   +2 more sources

Stereochemical determination of O-desmethylangolensin produced from daidzein

Food Chemistry, 2015
We had isolated an O-desmethylangolensin (O-DMA)-producing bacterium, Clostridium rRNA cluster XIVa strain SY8519. According to chiral separation using HPLC, the SY8519-produced O-DMA exhibited high optical purity. To determine the absolute stereochemistry of O-DMA, we prepared 2-(4-hydroxyphenyl)propionic acid (2-HPPA) from the O-DMA using the Baeyer ...
Toshio, Niwa   +5 more
openaire   +2 more sources

Daidzein and genistein content of fruits and nuts

The Journal of Nutritional Biochemistry, 2000
Dietary phytoestrogens such as the isoflavones daidzein and genistein are thought to protect against chronic diseases that are common in Western societies, such as cancer, osteoporosis, and ischemic heart disease. In addition, there are concerns regarding the deleterious effects of hormone-like compounds, especially with respect to the development of ...
Liggins, J   +5 more
openaire   +3 more sources

The metabolic fate of daidzein.

Scientia Sinica, 1977
A method using thin layer chromatography and ultraviolet spectrophotometry for isolation and quantitative determination of daidzein from biological specimens was developed. This method was found to be sensitive and specific and was used in this study for the observation of the metabolic fate of daidzein in animals and human bodies.
T L, Yueh, H Y, Chu
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Glycosylation of daidzein by the Eucalyptus cell cultures

Phytochemistry, 2008
The sequential glycosylation of a soybean isoflavone, daidzein, with cultured suspension cells of Eucalyptus perriniana and cyclodextrin glucanotransferase was studied. Daidzein was converted into two glycosylation products, daidzein 7-O-beta-D-glucopyranoside (39%) and daidzein 7-O-[6-O-(beta-D-glucopyranosyl)]-beta-D-glucopyranoside (beta ...
Kei, Shimoda   +4 more
openaire   +2 more sources

Anti-breast cancer potential of daidzein in rodents

Life Sciences, 2012
This study was carried out to explore anti-breast cancer potential of isoflavone daidzein or its related compounds using appropriate animal models and their anti-tumor mechanism.Daidzein or its major metabolite equol at a dose molar equivalent to tamoxifen [1.0 mg(2.7 μmol)/kg or 10 mg (27 μmol)/kg/day] was treated orally to rats bearing 7,12 ...
Xiaoping, Liu   +4 more
openaire   +2 more sources

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