Results 51 to 60 of about 58,757 (315)
Nickel Carcinogenesis Mechanism: DNA Damage [PDF]
International Journal of Molecular Sciences, 2019 Nickel (Ni) is known to be a major carcinogenic heavy metal. Occupational and environmental exposure to Ni has been implicated in human lung and nasal cancers. Currently, the molecular mechanisms of Ni carcinogenicity remain unclear, but studies have shown that Ni-caused DNA damage is an important carcinogenic mechanism.
Hongrui Guo +9 more
openaire +2 more sources
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Evaluation of fatigue life of polycrystalline structural alloys
MATEC Web of Conferences, 2018 A mathematical model describing the processes of elastoplastic deformation and damage accumulation under low-cycle loading has been developed, based on the viewpoint of mechanics of damaged media (MDM). The MDM model consists of three interrelated parts:
Volkov Ivan A. +2 more
doaj +1 more source
An Entropy Based Low-Cycle Fatigue Life Prediction Model for Solder Materials
Entropy, 2017 Fatigue damage is an irreversible progression which can be represented by the entropy increase, and it is well known that the second law of thermodynamics can describe an irreversible process.
Jundong Wang, Yao Yao
doaj +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Nihon Kikai Gakkai ronbunshu, 2016 Creep - fatigue analyses based on the concept of continuum damage mechanics were conducted for the combustion chamber used in a satellite's bipropellant thruster.
Tadashi MASUOKA +2 more
doaj +1 more source
Investigation on the ductile fracture of a high-strength dual-phase steel with anisotropic damage mechanics model [PDF]
, 2021 Zinan Li +4 more
openalex +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Some Models of Mechanics of Local Damage
Механика машин, механизмов и материалов, 2011 The technique for determination of local damage of complexly loaded mechanical system based on model of the deformable rigid body with dangerous volume is considered. Calculation of damage contact interaction is made.
O.M. Yelovoy
doaj