Results 91 to 100 of about 3,477,793 (285)

Haploidentical Hematopoietic Cell Transplantation for Infants With X‐Linked Severe Combined Immunodeficiency Using Post‐Transplant Cyclophosphamide

Pediatric Blood &Cancer, EarlyView.
Shuhei Takahashi, Akito Kawachi, Dan Tomomasa, Eri Watanabe, Yuji Fujita, Yuya Sato, Masahiro Sekiguchi, Kentaro Watanabe, Moe Hidaka, Akihiro Hoshino, Takahiro Kamiya, Masatoshi Takagi, Hirokazu Kanegane, Motohiro Kato   +13 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Mine hoisting steel wire rope surface damage image recognition based on improved YOLOv8n

Gong-kuang zidonghua
To address issues such as background interference caused by oil stains covering the surface of mine hoisting steel wire ropes, large gaps between rope strands leading to feature confusion, and the difficulty in identifying small target damages, a surface
MAO Qinghua, YANG Fan, WANG Chao, TONG Xuyao, TONG Junwei, ZHANG Xuhui, XUE Xusheng   +6 more
doaj   +1 more source

Crystal structure of the FeS cluster-containing nucleotide excision repair helicase XPD.

PLoS Biology, 2008
DNA damage recognition by the nucleotide excision repair pathway requires an initial step identifying helical distortions in the DNA and a proofreading step verifying the presence of a lesion.
Stefanie C Wolski, Jochen Kuper, Petra Hänzelmann, James J Truglio, Deborah L Croteau, Bennett Van Houten, Caroline Kisker   +6 more
doaj   +1 more source

Modeshapes recognition using Fourier descriptors: a simple SHM example [PDF]

, 2011
The main objective of this study is to develop an alternative criterion for modeshape classification, as the currently available one, MAC (Modal Assurance Criteria), is only a vector correlation representing modeshape similarities.
Morlier, Joseph, Bergh, Mauricio, Mevel, Laurent   +2 more
core  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Research on concrete structure damage detection based on piezoelectric sensing technology and morphological fractal method

Scientific Reports
This study proposes a concrete piezoelectric sensing detection method based on mathematical morphology and fractal theory, which effectively monitors and quantitatively assesses the dynamic evolution process of damage cracks in concrete structures under ...
Hanqing Zhong, Liwei Shuai, Dongmin Deng
doaj   +1 more source

Application of Pattern Recognition to Damage Localization

Computer-Aided Civil and Infrastructure Engineering, 1996
Pattern recognition is used as a basis to localize damage in structures. Feature vectors that depend on the predamaged and postdamaged mode shapes are developed. Classification criteria are developed to classify elements in the feature space into damaged and undamaged classes.
Norris Stubbs, Gabe Garcia
openaire   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source