Results 101 to 110 of about 3,477,793 (285)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

CANNOT READ--DAMAGE

The digitization of this collection was funded by a gift from EBSCO ...
CANNOT READ--DAMAGE
core   +4 more sources

Pattern recognition receptors and inflammasome: Now and beyond

Molecules and Cells
: Pattern recognition receptors (PRRs) are fundamental to the innate immune system, functioning to detect and eliminate invading pathogens by inhibiting their replication and limiting host tissue damage.
SuHyeon Oh, Young Ki Choi, SangJoon Lee
doaj   +1 more source

Architectural Insights for Post-Tornado Damage Recognition

CoRR
Rapid and accurate building damage assessment in the immediate aftermath of tornadoes is critical for coordinating life-saving search and rescue operations, optimizing emergency resource allocation, and accelerating community recovery. However, current automated methods struggle with the unique visual complexity of tornado-induced wreckage, primarily ...
Umeike, Robinson, Dao, Thang, Crawford, Shane, van de Lindt, John, Johnston, Blythe, Wanting, Wang, Do, Trung, Mofikoya, Ajibola, Banjara, Sarbesh, Pham, Cuong   +10 more
openaire   +3 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Neural networks and damage pattern recognition in power transformer diagnostics [PDF]

E3S Web of Conferences
The results of detecting deformations and damage of power transformer windings using the transformer Frequency Response Analysis (SFRA) are presented taking into account RG CIGRE A2.26, Standard IEC 60076-18, Standard IEEE C57.149.
Khrennikov Alexander, Aleksandrov Nikolay, Mikhailov Konstantin, Mikhailov Sergey   +3 more
doaj   +1 more source