Results 111 to 120 of about 3,477,793 (285)

Extracellular Self- and Non-Self DNA Involved in Damage Recognition in the Mistletoe Parasitism of Mesquite Trees. [PDF]

Int J Mol Sci, 2023
López-García CM, Ávila-Hernández CA, Quintana-Rodríguez E, Aguilar-Hernández V, Lozoya-Pérez NE, Rojas-Raya MA, Molina-Torres J, Araujo-León JA, Brito-Argáez L, González-Sánchez AA, Ramírez-Chávez E, Orona-Tamayo D.   +11 more
europepmc   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Application of Graph Convolutional Neural Networks Combined with Single-Model Decision-Making Fusion Neural Networks in Structural Damage Recognition. [PDF]

Sensors (Basel), 2023
Li X, Xu L, Guo H, Yang L.
europepmc   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Numerical Simulation and Application of Bench Blasting Mining in Dam Filling Construction

Applied Sciences
The long-term safety of rockfill dams is critically dependent on the quality of the filling material. Therefore, it is essential to predict the blasting grading distribution scientifically and accurately.
Gengquan Li, Yingkang Yao, Yingguo Hu, Rui Nie, Congcong Hou   +4 more
doaj   +1 more source

Insights into Mechanisms of Damage Recognition and Catalysis by APE1-like Enzymes. [PDF]

Int J Mol Sci, 2022
Bulygin AA, Fedorova OS, Kuznetsov NA.
europepmc   +1 more source

An artificial immune pattern recognition approach for damage classification in structures

, 2011
Structural Health Monitoring (SHM) is one of the research topics that have received growing interest in research communities. While a lot of efforts have been made in detecting damages in structures, very few researches have been conducted for the ...
Zhou, Rui, Tang S(唐世), Zhou Y(周悦), Zang CZ(臧传治)   +3 more
core  

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Autologous K63 deubiquitylation within the BRCA1-A complex licenses DNA damage recognition. [PDF]

J Cell Biol, 2022
Jiang Q, Foglizzo M, Morozov YI, Yang X, Datta A, Tian L, Thada V, Li W, Zeqiraj E, Greenberg RA.   +9 more
europepmc   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source