Results 11 to 20 of about 1,571,262 (350)
Inhibition of MRN activity by a telomere protein motif
Nature Communications, 2021 Telomeres suppress the DNA damage response at chromosome ends. Here the authors show that in budding yeast the activity of the MRX complex in DNA repair and DNA damage signaling is inhibited by telomeric protein Rif2 via a short motif at the N-terminus.
Freddy Khayat +11 more
doaj +1 more source
Royal Society Open Science, 2021 Unlike bacteria, mammalian cells need to complete DNA replication before segregating their chromosomes for the maintenance of genome integrity. Thus, cells have evolved efficient pathways to restore stalled and/or collapsed replication forks during S ...
Camelia Mocanu, Kok-Lung Chan
doaj +1 more source
Stability Analysis of Near-Wellbore Reservoirs Considering the Damage of Hydrate-Bearing Sediments [PDF]
Journal of Marine Science and Engineering, 2019 Xiaoliang Zhang +3 more
exaly +2 more sources
Stability of non-localized responses for damaging materials [PDF]
Vietnam Journal of Mechanics, 2008 This work is devoted to the analysis of the stability of the homogeneous states of a bar made of a brittle strain softening material submitted to a tensile loading. We distinguish two types of damage models: local damage models and gradient damage models. We show that a local damage model necessarily leads to the unstability of the homogeneous response
Marigo, Jean-Jacques, Pham, Kim
openaire +4 more sources
Vibration and buckling of open TWBs with local weakening [PDF]
, 2017 Free vibration and Ljapounov stability of compressed open thin-walled beams with a cross-section reduction are studied by a in-house finite differences numerical code, based on a refined direct beam model and allowing for investigating elastic stability ...
Carpinteri, A. +3 more
core +1 more source
A nucleotide resolution map of Top2-linked DNA breaks in the yeast and human genome
Nature Communications, 2019 Topoisomerase 2 (Top2) is known to resolve DNA topological stress through double strand breaks (DSBs), yet Top2 inhibition has been reported to result in a significant amount of single-strand breaks (SSBs).
William H. Gittens +5 more
doaj +1 more source
Allocation Rules and the Stability of Mass Tort Class Actions [PDF]
, 2018 This paper studies the effects of allocation rules on the stability of mass tort class actions. I analyze a two-stage model in which a defendant faces multiple plaintiffs with heterogeneous damage claims.
Teitelbaum, Joshua C.
core +2 more sources
Ensuring the Stability of the Genome: DNA Damage Checkpoints [PDF]
The Scientific World JOURNAL, 2001 The cellular response to DNA damage is vital for the cell s ability to maintain genomic integrity. Checkpoint signalling pathways, which induce a cell cycle arrest in response to DNA damage, are an essential component of this process. This is reflected by the functional conservation of these pathways in all eukaryotes from yeast to mammalian cells ...
Christine Latif +2 more
openaire +3 more sources
Nature Communications, 2019 The kinase PLK1 has important roles during cell division, including mitotic entry and bipolar spindle formation. Here, the authors show that PLK1 also functions in centromere protection, with loss leading to DNA unwinding by Bloom’s syndrome helicase and
Owen Addis Jones +4 more
doaj +1 more source
Cell Reports, 2020 Summary: Centrosome separation in late G2/ early prophase requires precise spatial coordination that is determined by a balance of forces promoting and antagonizing separation. The major effector of centrosome separation is the kinesin Eg5.
Tom Stiff +5 more
doaj +1 more source