Results 41 to 50 of about 619,613 (312)
Wellcome Open Research, 2021 Background: In vitro experiments utilising the reconstituted Saccharomyces cerevisiae eukaryotic replisome indicated that the efficiency of the leading strand replication is impaired by a moderate increase in Polδ concentration.
Róbert Zach, Antony M. Carr
doaj +1 more source
BAF180 Promotes Cohesion and Prevents Genome Instability and Aneuploidy
Cell Reports, 2014 BAF180, a subunit of the PBAF chromatin remodeling complex, is frequently mutated in cancer. Although PBAF regulates transcription, it remains unclear whether this is what drives tumorigenesis in cells lacking BAF180.
Peter M. Brownlee +4 more
doaj +1 more source
On an isotropic damage mechanics model for ductile materials [PDF]
, 2022 S.325-346A new model for combined elastoplasticity and damage is proposed. The model is based on the maximum dissipation principle and implements a strong coupling between plasticity and damage.
Hesebeck, O.
core
Maintaining Genome Stability in Defiance of Mitotic DNA Damage [PDF]
Frontiers in Genetics, 2016 The implementation of decisions affecting cell viability and proliferation is based on prompt detection of the issue to be addressed, formulation and transmission of a correct set of instructions and fidelity in the execution of orders. While the first and the last are purely mechanical processes relying on the faithful functioning of single proteins ...
Ferrari, Stefano, Gentili, Christian
openaire +4 more sources
Wellcome Open Research, 2021 Background: In vitro experiments utilising the reconstituted Saccharomyces cerevisiae eukaryotic replisome indicated that the efficiency of the leading strand replication is impaired by a moderate increase in Polδ concentration.
Róbert Zach, Antony M. Carr
doaj +1 more source
The vital influence of permeable volume on the damage stability of passenger ships [PDF]
, 2022 Ships are designed based on three basic objectives pertaining to ship performance, functionally and safety, all dictated by external shape, internal layout, deadweight, payload, permeable volume, and their distributions.
Mujeeb Ahmed +4 more
core
Specialized interfaces of Smc5/6 control hinge stability and DNA association
Nature Communications, 2017 Structural Maintenance of Chromosomes (SMC) complexes maintain genome integrity by regulating the segregation of chromosomes. Here, Altet al. describe the structure of the heterodimeric Smc5/6-hinge from fission yeast and define functional features ...
Aaron Alt +10 more
doaj +1 more source
DNA damage can alter the stability of nucleosomes: Effects are dependent on damage type [PDF]
Proceedings of the National Academy of Sciences, 1997 We have investigated the effects of DNA damage by (±)- anti -benzo[ a ]pyrene diol epoxide (BPDE) and UV light on the formation of a positioned nucleosome in the Xenopus borealis 5S rRNA gene.
Mann, David B +2 more
openaire +3 more sources
TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription
Nature Communications, 2017 DNA double-strand breaks (DSBs) induced by topoisomerase II (TOP2) are rejoined by TDP2-dependent non-homologous end-joining (NHEJ) but whether this promotes or suppresses translocations is not clear. Here the authors show that TDP2 suppresses chromosome
Fernando Gómez-Herreros +6 more
doaj +1 more source
A Bibliometric Analysis of Publications in Uremic Toxins From 1991 to 2024
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Uremic toxins are a growing area of research in nephrology, with significant implications in the progression and treatment of chronic kidney disease (CKD) and the management of end‐stage kidney disease (ESKD). This bibliometric analysis aims to evaluate the global research trends, key contributors, and the impact of publications in ...
Yuh‐Shan Ho +7 more
wiley +1 more source