Results 21 to 30 of about 1,571,262 (350)
Wellcome Open Research, 2022 Single-molecule localisation microscopy (SMLM) uses software to extract super-resolved positions from microscope images of fluorescent molecules. These localisations can then be used to render super-resolution images or analysed to extract information ...
Antony M. Carr +2 more
doaj +1 more source
Biomechanical stability of hernia-damaged abdominal walls
Scientific Reports, 2023 AbstractHernia occurs when the peritoneum and/or internal organs penetrate through a defect in the abdominal wall. Implanting mesh fabrics is a common way to reinforce the repair of hernia-damaged tissues, despite the risks of infection and failure associated with them.
Ali Karrech +2 more
openaire +3 more sources
A robust numerical framework for the analysis of material failure of fibre reinforced soft tissue [PDF]
, 2011 In this work, robustness and stability of continuum damage models applied to material failure in soft tissues are addressed. In the implicit damage models equipped with softening, the presence of negative eigenvalues in the tangent ...
Blanco Ibáñez, Sergio +2 more
core +4 more sources
Damage stability of cruise ships - evidence and conjecture [PDF]
, 2015 This paper delves into damage stability legislation as it applies to passenger ships. The Concordia accident, like many others before it, has shaken the maritime profession once again with many questions being asked without being able to provide credible
Vassalos, Dracos
core +3 more sources
Nature Communications, 2016 Werner syndrome is a progeroid disease characterised by genetic instability due to mutations to the WRN helicase/exonuclease. Here the authors define a novel Ku binding motif (KBM) and show that two such motifs facilitate the involvement of WRN in DNA ...
Gabrielle J. Grundy +7 more
doaj +1 more source
Cohesin causes replicative DNA damage by trapping DNA topological stress [PDF]
, 2020 DNA topological stress inhibits DNA replication fork (RF) progression and contributes to DNA replication stress. In Saccharomyces cerevisiae, we demonstrate that centromeric DNA and the rDNA array are especially vulnerable to DNA topological stress ...
Baxter, Jonathan +2 more
core +1 more source
Nature Communications, 2018 Chromosome instability is associated with cancer formation. Here the authors identify in cultured human cancer cells a non-canonical DNA bridge breakage pathway leading to chromosome missegregation and rearrangements triggered by sister DNA ...
Ankana Tiwari +2 more
doaj +1 more source
Mitochondrial damage checkpoint in apoptosis and genome stability [PDF]
FEMS Yeast Research, 2004 Mitochondria perform multiple cellular functions including energy production, cell proliferation and apoptosis. Studies described in this paper suggest a role for mitochondria in maintaining genomic stability. Genomic stability appears to be dependent on mitochondrial functions involved in maintenance of proper intracellular redox status, ATP-dependent
openaire +2 more sources
HSP90-CDC37-PP5 forms a structural platform for kinase dephosphorylation
Nature Communications, 2022 Binding to HSP90-CDC37 is essential for the activity of many protein kinases, but its function is unclear. Here, the authors show that HSP90-CDC37 provides a structural platform for the phosphatase PP5 to dephosphorylate a bound kinase, ‘factory ...
Jasmeen Oberoi +6 more
doaj +1 more source
Contribution of DNA repair and cell cycle checkpoint arrest to the maintenance of genomic stability [PDF]
, 2006 DNA damage response mechanisms encompass pathways of DNA repair, cell cycle checkpoint arrest and apoptosis. Together, these mechanisms function to maintain genomic stability in the face of exogenous and endogenous DNA damage.
Ahnesorg +41 more
core +1 more source