Results 31 to 40 of about 1,571,262 (350)
Molecular basis for DNA repair synthesis on short gaps by mycobacterial Primase-Polymerase C
Nature Communications, 2020 Mycobacteria Prim-PolC performs short gap synthesis following removal of lesions during excision repair. Here the authors resolve crystal structures of pre- and post-catalytic Prim-PolC complexes bound to gapped DNA substrates to define its mechanism.
Nigel C. Brissett +7 more
doaj +1 more source
Wellcome Open Research, 2021 Background: In vitro experiments utilising the reconstituted Saccharomyces cerevisiae eukaryotic replisome indicated that the efficiency of the leading strand replication is impaired by a moderate increase in Polδ concentration.
Róbert Zach, Antony M. Carr
doaj +1 more source
BAF180 Promotes Cohesion and Prevents Genome Instability and Aneuploidy
Cell Reports, 2014 BAF180, a subunit of the PBAF chromatin remodeling complex, is frequently mutated in cancer. Although PBAF regulates transcription, it remains unclear whether this is what drives tumorigenesis in cells lacking BAF180.
Peter M. Brownlee +4 more
doaj +1 more source
Damage spreading and dynamic stability of kinetic Ising models
, 1996 We investigate how the time evolution of different kinetic Ising models depends on the initial conditions of the dynamics. To this end we consider the simultaneous evolution of two identical systems subjected to the same thermal noise. We derive a master
Coniglio A +11 more
core +1 more source
Maintaining Genome Stability in Defiance of Mitotic DNA Damage [PDF]
Frontiers in Genetics, 2016 The implementation of decisions affecting cell viability and proliferation is based on prompt detection of the issue to be addressed, formulation and transmission of a correct set of instructions and fidelity in the execution of orders. While the first and the last are purely mechanical processes relying on the faithful functioning of single proteins ...
Ferrari, Stefano, Gentili, Christian
openaire +4 more sources
An Investigation into the Radiation Damage of the Silicon Detectors of the H1-PLUG Calorimeter within the HERA environment [PDF]
, 1995 The silicon detectors used in the H1-PLUG calorimeter have shown increasing aging effects during the '94 run period of the electron proton storage ring HERA.
Hildesheim, W., Seidel, M.
core +2 more sources
Wellcome Open Research, 2021 Background: In vitro experiments utilising the reconstituted Saccharomyces cerevisiae eukaryotic replisome indicated that the efficiency of the leading strand replication is impaired by a moderate increase in Polδ concentration.
Róbert Zach, Antony M. Carr
doaj +1 more source
China’s emerging global role: dissatisfied responsible great power [PDF]
, 2010 China has (re)emerged as a great power in a world not of its own making. The distribution of power in major organisations and the dominant norms of international interactions are deemed to unfairly favour the existing Western powers, and at times ...
Bernstein R. +22 more
core +1 more source
Specialized interfaces of Smc5/6 control hinge stability and DNA association
Nature Communications, 2017 Structural Maintenance of Chromosomes (SMC) complexes maintain genome integrity by regulating the segregation of chromosomes. Here, Altet al. describe the structure of the heterodimeric Smc5/6-hinge from fission yeast and define functional features ...
Aaron Alt +10 more
doaj +1 more source
Dynamic stability analysis with nonlocal damage [PDF]
Computers & Structures, 1988 Abstract The classic localization instability analysis for strain-softening materials is expanded to dynamic solutions. The nonlocal continuum with local strain, which ensures proper convergence of finite element calculations and physically realistic solutions, is adopted in its simplified form, the nonlocal damage model.
Gilles Pijaudier-Cabot +1 more
openaire +1 more source