Results 51 to 60 of about 1,571,262 (350)
Cell Reports, 2015 53BP1 plays multiple roles in mammalian DNA damage repair, mediating pathway choice and facilitating DNA double-strand break repair in heterochromatin. Although it possesses a C-terminal BRCT2 domain, commonly involved in phospho-peptide binding in other
Robert A. Baldock +7 more
doaj +1 more source
NASA space materials research [PDF]
, 1985 The effect of the space environment on: (1) thermal control coatings and thin polymer films; (2) radiation stability of 250 F and 350 F cured graphite/epoxy composites; and (3) the thermal mechanical stability of graphite/epoxy, graphite/glass composites
Sykes, G. F. +2 more
core +1 more source
Age structure landscapes emerge from the equilibrium between aging and rejuvenation in bacterial populations. [PDF]
, 2018 The physiological asymmetry between daughters of a mother bacterium is produced by the inheritance of either old poles, carrying non-genetic damage, or newly synthesized poles.
Buetz, Christen +4 more
core +3 more sources
Prevalence and Trajectory of Household Material Hardship Among Children With Advanced Cancer
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background/Objectives Families of children with advanced cancer living in poverty experience inferior outcomes including poor parent mental health and worse child quality of life. Household material hardship (HMH: food, housing, transportation, and/or utility insecurity) is a modifiable poverty exposure—and potential intervention target—that ...
Sarah Wright +13 more
wiley +1 more source
Centromere protection requires strict mitotic inactivation of the Bloom syndrome helicase complex
Nature CommunicationsThe BTRR (BLM/TOP3A/RMI1/RMI2) complex resolves DNA replication and recombination intermediates to maintain genome stability. Alongside PICH, they target mitotic DNA intertwinements, known as ultrafine DNA bridges, facilitating chromosome segregation ...
María Fernández-Casañas +8 more
doaj +1 more source
Molecular Basis for DNA Double-Strand Break Annealing and Primer Extension by an NHEJ DNA Polymerase
Cell Reports, 2013 Nonhomologous end-joining (NHEJ) is one of the major DNA double-strand break (DSB) repair pathways. The mechanisms by which breaks are competently brought together and extended during NHEJ is poorly understood.
Nigel C. Brissett +5 more
doaj +1 more source
Radiation induced DNA damage responses [PDF]
, 2006 The amazing feature of ionising radiation (IR) as a DNA damaging agent is the range of lesions it induces. Such lesions include base damage, single strand breaks (SSBs), double strand breaks (DSBs) of varying complexity and DNA cross links.
Jeggo, Penny, Löbrich, Markus
core +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background The management of clinically apparent single lesions or oligofocal nephroblastomatosis, a facultative precursor of nephroblastoma, remains debated. Methods We retrospectively analyzed 37 patients with clinically apparent single or oligofocal nephroblastomatosis (two to three lesions per kidney) among 2347 patients registered between
Nils Welter +17 more
wiley +1 more source
Wellcome Open Research, 2017 The use of constitutive promoters to drive exogenous protein expression is an important tool for the study of diverse biological processes. To create and characterise a stably integrated expression system for DT40 cells, we constructed integration ...
Meliti Skouteri +2 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu +8 more
wiley +1 more source