Results 71 to 80 of about 875,259 (309)
EngIn nature, organisms have evolved unique structures that feature low weight, high strength, and damage resistance. The Eurasian eagle-owl serves as a representative example, with specialized feather architectures that enable stable flight in intense and ...
Jing Yan, Yi Li
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Fatigue of Aircraft Structures, 2015 Knowledge about loads occurring in the structure during aircraft operation is vital from the point of view of the damage tolerance approach to aircraft design. In the best-life scenario, such information could be available from a network of sensors, e.g.
Dziendzikowski Michał +6 more
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Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
The effect of resin on the impact damage tolerance of graphite-epoxy laminates [PDF]
The effect of the matrix resin on the impact damage tolerance of graphite-epoxy composite laminates was investigated. The materials were evaluated on the basis of the damage incurred due to local impact and on their ability to retain compression strength
Rhodes, M. D., Williams, J. G.
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The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
ACEE composite structures technology [PDF]
Toppics addressed include: advanced composites on Boeing commercial aircraft; composite wing durability; damage tolerance technology development; heavily loaded wing panel design; and pressure containment and damage tolerance in ...
Johnson, Ronald W. +3 more
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Realising damage-tolerant nacre-inspired CFRP
Journal of the Mechanics and Physics of Solids, 2017 Abstract In this work, a nacre-inspired Carbon Fibre Reinforced Polymer (CFRP) composite is designed, synthesised and tested. Analytical and numerical models are used to design a tiled micro-structure, mimicking the staggered arrangement of ceramic platelets in nacre and exploiting geometrical interlocks for crack deflection and damage diffusion. The
F. Narducci, K.-Y. Lee, S.T. Pinho
openaire +3 more sources
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Progressive failure methodologies for predicting residual strength and life of laminated composites [PDF]
Two progressive failure methodologies currently under development by the Mechanics of Materials Branch at NASA Langley Research Center are discussed. The damage tolerance/fail safety methodology developed by O'Brien is an engineering approach to ensuring
Allen, David H. +2 more
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Comparison of Riveted Panel and Integral Panel for Damage Tolerance by using FEA [PDF]
, 2014 Damage tolerance capability refers to the load carrying capacity of a damaged structure. In an aircraft metallic structure damage is the fatigue crack. The presence of a fatigue crack reduce the load carrying capacity of a structure.
Shantharaja, M., Srinivas, K.R.
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