Results 111 to 120 of about 6,560,570 (376)
RNA damage and its implications in genome stability
DNA RepairEndogenous and environmental stressors can damage DNA and RNA to compromise genome and transcriptome stability and integrity in cells, leading to genetic instability and diseases. Recent studies have demonstrated that RNA damage can also modulate genome stability via RNA-templated DNA synthesis, suggesting that it is essential to maintain RNA integrity
Mustapha Olatunji, Yuan Liu
openaire +2 more sources
On the calculation of the righting lever curve for a damaged ship
, 2018 The current damage stability criteria for ships are mainly based on the characteristics of the righting lever curve. The related calculations for different intermediate stages during the flooding process, and for the final equilibrium condition, are ...
P. Ruponen, T. Manderbacka, D. Lindroth
semanticscholar +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
A theoretical derivation of the Hoek–Brown failure criterion for rock materials
Journal of Rock Mechanics and Geotechnical Engineering, 2015 This study uses a three-dimensional crack model to theoretically derive the Hoek–Brown rock failure criterion based on the linear elastic fracture theory.
Jianping Zuo, Huihai Liu, Hongtao Li
doaj +1 more source
A method for breach assessment onboard a damaged passenger ship
, 2017 Reliable analysis of stability and safety level in a flooding emergency onboard a damaged passenger ship is extremely important for making correct decisions on evacuation and abandonment. Thus there is demand for an automated system that detects flooding
P. Ruponen, A. Pulkkinen, J. Laaksonen
semanticscholar +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Mechanisms of base selection by the E.coli mispaired uracil glycosylase [PDF]
, 2008 The repair of the multitude of single-base lesions formed daily in the cells of all living organisms is accomplished primarily by the base-excision repair (BER) pathway that initiates repair through a series of lesion-selective glycosylases.
Darwanto, Agus +6 more
core +2 more sources
Effect of Oxidative Damage on the Stability and Dimerization of Superoxide Dismutase 1
Biophysical Journal, 2016 During their life cycle, proteins are subject to different modifications involving reactive oxygen species. Such oxidative damage to proteins may lead to the formation of insoluble aggregates and cytotoxicity and is associated with age-related disorders ...
D. Petrov, X. Daura, B. Žagrović
semanticscholar +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Linear mitochondrial DNA is rapidly degraded by components of the replication machinery
Nature Communications, 2018 Damaged linearized mtDNA needs to be removed from the cell for mitochondrial genome stability. Here the authors shed light into the identity of the machinery responsible for rapidly degrading linearized DNA, implicating the role of mtDNA replication ...
Viktoriya Peeva +12 more
doaj +1 more source