Results 91 to 100 of about 172,653 (302)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Stability Assessment of Drill Ship Using Probabilistic Damage Stability Analysis
, 2019 Drill ship is a ship-shaped structure with a drilling unit at its center and with oil compartments, which is moored and kept in position using anchors.
Mohan, Poonam +3 more
core +2 more sources
A theoretical derivation of the Hoek–Brown failure criterion for rock materials
Journal of Rock Mechanics and Geotechnical Engineering, 2015 This study uses a three-dimensional crack model to theoretically derive the Hoek–Brown rock failure criterion based on the linear elastic fracture theory.
Jianping Zuo, Huihai Liu, Hongtao Li
doaj +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Dynamics and Adaptive Control for Stability Recovery of Damaged Aircraft
, 2006 This paper presents a recent study of a damaged generic transport model as part of a NASA research project to investigate adaptive control methods for stability recovery of damaged aircraft operating in off-nominal flight conditions under damage and or ...
Nespeca, Pascal +3 more
core +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Stability Analysis of Seismically Damaged Embankments
, 1988 This paper describes a pseudo-static stability analysis of seismically damaged embankments during the 1983 Nihonkai-chubu earthquake (Japan). It places a great emphasis on the discussion of a dynamic shear strength of soils to be used in a seismic ...
Koga, Yasuyuki, Matsuo, Osamu
core +1 more source
AerospaceIn response to the urgent need for performance predictions of damaged aerospace structures, this study undertakes a comprehensive investigation into the flutter characteristics of damaged variable-stiffness composite laminate (VSCL) plates. The governing
Pingan Zou +3 more
doaj +1 more source
Linear mitochondrial DNA is rapidly degraded by components of the replication machinery
Nature Communications, 2018 Damaged linearized mtDNA needs to be removed from the cell for mitochondrial genome stability. Here the authors shed light into the identity of the machinery responsible for rapidly degrading linearized DNA, implicating the role of mtDNA replication ...
Viktoriya Peeva +12 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source