Results 71 to 80 of about 172,653 (302)

The Role of the ITTC in the Physical Modelling of Damaged Stability in Waves

open access: yes, 1996
This report was prepared in response to a workshop on stability work relevant to the ITTC, to be held on September 18th, 1996. It describes IMD's proposals for the role of the ITTC in model testing damaged ships.NRC publication ...
Molyneux, W. D.
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Damage stability of ships as a safety criterion for optimisation tools

open access: yes, 2006
A literature overview of past optimisation studies revealed that whilst satisfaction of intact stability requirements has been built into existing alternative hull form optimisation packages, seeking improved hydrodynamic hull forms in terms of ...
Saydan, Deniz, Saydan, Deniz .
core  

Stability Evaluation of a Damaged Ship with Ice Accumulation in Arctic Regions

open access: yesJournal of Marine Science and Engineering
The harsh environment in Arctic regions presents significant challenges to ship stability, particularly when ice accumulation and hull damage occur simultaneously, potentially increasing the risk of instability.
Jiabin Tao   +5 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Utilization of Differential Thrust for Lateral/Directional Stability of a Commercial Aircraft with a Damaged Vertical Stabilizer

open access: yes, 2015
This thesis investigates the utilization of differential thrust to help a commercial aircraft with a damaged vertical stabilizer regain its lateral/directional stability.
Lu, Long
core   +2 more sources

The CFD Method-Based Research on Damaged Ship’s Flooding Process in Time-Domain

open access: yesPolish Maritime Research, 2019
The flooding process is one of the main concerns of damaged ship stability. This paper combines the volume of fluid (VOF) method incorporated in the Navier-Stokes (NS) solver with dynamic mesh techniques to simulate the flooding of a damaged ship.
Li-Fen Hu   +4 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

The hydrodynamic and dynamic motion analysis of a damaged ship

open access: yes, 2008
The hydrodynamic analysis and motion response of a damaged ship requires a novel generalisation of the methodsnormally applied to intact ships or other floating structures. Damaged ship statistics are used to provide likely damage scenarios.
Hearn, G.E.   +3 more
core  

Pipeline burst-related ground stability in blowout condition

open access: yes, 2021
Sinkhole incidents have increased rapidly in recent decades due to water main breaks. Although numerous researchers have recently conducted investigations in sinkhole phenomenon, most of the studies are related to natural sinkhole formation, underground ...
Mahalingasivam, Kiritharan   +7 more
core   +1 more source

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