Results 61 to 70 of about 6,560,570 (376)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Emergency Survey and Stability Analysis of a Rainfall-Induced Soil-Rock Mixture Landslide at Chongqing City, China

Frontiers in Earth Science, 2021
The stability analysis of damaged landslides and unstable debris is important for rescue work and emergency operations. This paper investigates a predisposed geological emergence, inducing the factors and deformation processes of the Zhongbao landslide ...
Chang Zhou, Dong Ai, Wei Huang, Huiyuan Xu, Liwen Ma, Lichuan Chen, Luqi Wang   +6 more
doaj   +1 more source

Aging cellular networks: chaperones as major participants

, 2006
We increasingly rely on the network approach to understand the complexity of cellular functions. Chaperones (heat shock proteins) are key "networkers", which have among their functions to sequester and repair damaged protein. In order to link the network
Agoston, Barabasi, Blais, Borodina, C. Sőti, Chan, Cherian, Cowen, Csermely, Csermely, Csermely, Csermely, Donaldson, Dorogovtsev, Dukan, Fares, Ferrarini, Gavin, Goldberger, Hayflick, He, Herndon, Heydari, Himmelstein, Imai, Irish, Macario, Morimoto, Mukai, Nardai, Nardai, Nollen, P. Csermely, Paulsson, Promislow, Pál, Queitsch, Rual, Rutherford, Schwarzer, Song, Stadtman, Stelzl, Sőti, Sőti, Sőti, Sőti, von Mering, Werner-Washburne, Westerheide, White, Yam, Young, Young, Zhao, Zhu, Zou   +56 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Evaluation of dynamic stability for damaged ships under wind and wave conditions

Zhongguo Jianchuan Yanjiu
Objectives Ships may encounter accidents such as collisions, groundings, and reef impacts during navigation, which can lead to hull damage and flooding, thereby significantly reducing buoyancy and stability. Under wind and wave conditions, a damaged ship'
Wei CHAI, Jiaxing ZHANG, Peiyuan FENG, Xiaonan YANG, Jun WU, Jianzhang QI   +5 more
doaj   +1 more source

Radiation tolerance of nanocrystalline ceramics: insights from Yttria Stabilized Zirconia. [PDF]

, 2015
Materials for applications in hostile environments, such as nuclear reactors or radioactive waste immobilization, require extremely high resistance to radiation damage, such as resistance to amorphization or volume swelling.
Castro, Ricardo HR, Dey, Sanchita, Drazin, John W, Holesinger, Terry G, Uberuaga, Blas P, Valdez, James A, Wang, Yongqiang   +6 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Spatial Analysis of Wenchuan Earthquake-Damaged Vegetation in the Mountainous Basins and Its Applications

Remote Sensing, 2015
The 2008 Wenchuan Earthquake induced landslides that destroyed large swaths of mountain vegetation. Presently, the damaged vegetation areas are exhibiting various stages of recovery depending on environments.
Huaizhen Zhang, Tianhe Chi, Jianrong Fan, Kaiheng Hu, Ling Peng   +4 more
doaj   +1 more source

Stability of misoprostol tablets collected in Malawi and Rwanda: Importance of intact primary packaging.

PLoS ONE, 2020
Misoprostol is listed in the WHO essential medicines list and can be used for induction of labour, for prevention and treatment of post-partum haemorrhage, and for abortions.
Nhomsai Hagen, Thomas Bizimana, P Claver Kayumba, Felix Khuluza, Lutz Heide   +4 more
doaj   +1 more source

Weakening laws of rock mass properties in blasting excavation damage zone of high rock slopes

Yantu gongcheng xuebao, 2020
The weakening of rock mass properties caused by blasting excavation has an adverse effect on slope stability. The Hoek-Brown (H-B) criterion is one of the effective approaches to quickly estimate the mechanical properties of the damaged rock mass.
YANG Jian-hua 1, 2, DAI Jin-hao 1, 2, YAO Chi 1, 2, JIANG Shui-hua 1, 2, JIANG Qing-hui 1, 2
doaj   +1 more source