Results 31 to 40 of about 57,526 (264)

Oncolytic peptide LTX-315 induces an immune-mediated abscopal effect in a rat sarcoma model

OncoImmunology, 2017
LTX 315 is an oncolytic peptide with potent immunological properties. In the present study, we demonstrate that intratumoral treatment with LTX-315 resulted in a complete regression and systemic immune response in a rat fibrosarcoma model.
Janne Nestvold, Meng-Yu Wang, Ketil A. Camilio, Severin Zinöcker, Torunn Elisabeth Tjelle, Alf Lindberg, Bengt Erik Haug, Gunnar Kvalheim, Baldur Sveinbjørnsson, Øystein Rekdal   +9 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Ciprofloxacin is a novel anti-ferroptotic antibiotic

Heliyon
Cancer patients undergoing chemotherapy are susceptible to various bacterial infections, necessitating prompt and precise antimicrobial treatment with antibiotics.
Fangquan Chen, Hu Tang, Junhao Lin, Rui Kang, Daolin Tang, Jiao Liu   +5 more
doaj   +1 more source

The rationale for using Periplaneta americana as a monarch drug of TCM in the treatment of damp-heat ulcerative colitis

Informatics in Medicine Unlocked, 2021
The aim of this research was to quantitatively and comprehensively explore the therapeutic effects and mechanism of action of traditional Chinese medicine (TCM) formulas, using Periplaneta americana as a monarch drug, against damp-heat ulcerative colitis
Ang Lu, Lei Tao, Qi-Yan Li, Jing-Na Zhang, Miao Tang, Wan-Xin Yu, Yu-Jia Wang, Zhi-Qiong Ai, Yu Zhao, Heng Liu, Xiu-Mei Wu   +10 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

CYP51A1 in health and disease: from sterol metabolism to regulated cell death

Cell Death Discovery
How do cells precisely coordinate sterol metabolism with survival and death signals in diverse physiological and pathological contexts? This fundamental question has gained increasing attention as accumulating evidence reveals that enzymes traditionally ...
Fangquan Chen, RuiRui Liang, Jieting Zhang, Rui Kang, Daolin Tang, Jiao Liu   +5 more
doaj   +1 more source

Mitochondrial DNA as DAMP in critical conditions

Бюллетень сибирской медицины, 2019
The focus of the researchers’ attention today includes the recently discovered role of mitochondria in the immune response. Increasing evidence shows that mitochondrial DNA, in retaining some of their characteristics of the ancient α-proteobacteria’s ...
E. V. Grigoriev, R. R. Salakhov, M. V. Golubenko, A. V. Ponasenko, D. L. Shukevich, V. G. Matveeva, A. S. Radivilko, A. V. Tsepokina, E. A. Velikanova, R. S. Kornelyuk, A. S. Ivkin   +10 more
doaj   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

CYP51A1 drives resistance to pH-dependent cell death in pancreatic cancer

Nature Communications
Disrupted pH homeostasis can precipitate cell death and represents a viable therapeutic target in oncological interventions. Here, we utilize mass spectrometry-based drug analysis, transcriptomic screens, and lipid metabolomics to explore the metabolic ...
Fangquan Chen, Hu Tang, Changfeng Li, Rui Kang, Daolin Tang, Jiao Liu   +5 more
doaj   +1 more source