Results 1 to 10 of about 10,610 (205)

Delphi Consensus on Attenuated Androgen Use for Long‐Term Prophylaxis in Hereditary Angioedema: AURA Project [PDF]

Clinical and Translational Allergy
Background Danazol and other attenuated androgens (AAs) have been a cornerstone of Hereditary Angioedema (HAE) long‐term prophylaxis (LTP) for decades, alongside intravenous plasma‐derived C1INH (pdC1INH). Danazol's potential androgenic effects, however,
Eunice Dias de Castro, Luís Miguel Cardoso, João Jácome de Castro, Manuel Branco Ferreira   +3 more
doaj   +2 more sources

Therapeutic Targets for Lung Squamous Cell Carcinoma: Proteome-Wide Mendelian Randomization and Potential Drug Prediction. [PDF]

Clin Respir J
This flowchart shows the main contents of our study, including main analysis, sensitivity analysis, and survival analysis. The figure briefly shows the source of our data, as well as some other screening requirements. The main finding of mendelian randomization was that three of the plasma proteins were shown to be associated with the risk of LUSC ...
Xiang T, Hu T, Sun J, Geng Q, Yang J, Jian Z.   +5 more
europepmc   +2 more sources

Abdominal Wall Endometriosis Postcesarean Section: Diagnosis, Surgical Management, and Case Study of Extensive Uterine Adhesion. [PDF]

Case Rep Obstet Gynecol
Introduction Endometriosis involves ectopic endometrial tissue outside the uterus, commonly in the pelvis but sometimes affecting organs like the urinary tract, gastrointestinal system, and respiratory tract. Abdominal wall endometriosis (AWE) is a rare subtype where endometrial tissue infiltrates the abdominal wall, often occurring secondarily in ...
Hashemi M, Dehghan M.
europepmc   +2 more sources

Assessment of potential drug-drug interactions in patients with hereditary angioedema from the ITACA cohort: simulations from a real-life dataset considering danazol versus berotralstat [PDF]

Frontiers in Pharmacology
BackgroundDanazol is regularly used as a prophylactic treatment in patients with Hereditary angioedema due to C1-inhibitor deficiency (HAE-C1INH). However, this drug is characterized by a risk of drug-drug interactions (DDIs).
Andrea Zanichelli, Andrea Zanichelli, Dario Cattaneo, Antonio Gidaro, Riccardo Senter, Francesco Arcoleo, Pietro Accardo, Donatella Bignardi, Paolo Borrelli, Caterina Colangelo, Tiziana De Pasquale, Davide Firinu, Francesca Perego, Massimo Triggiani, Giuseppe Spadaro, Chiara Cogliati, Emanuele Bizzi, Valentina Popescu Janu, Maria Domenica Guarino, Paolina Quattrocchi, Luisa Brussino, Oliviero Rossi, Paola Triggianese, Stefano Agolini, Francesco Giardino, Vincenzo Montinaro, Mauro Cancian   +26 more
doaj   +2 more sources

Efficacy and safety of danazol for pulmonary fibrosis or bone-marrow failure associated with telomere-related gene mutation [PDF]

ERJ Open Research
Background Telomere-related gene (TRG) pathogenic variants are detected in ∼30% of familial pulmonary fibrosis (PF) cases. Danazol, a synthetic sex hormone with androgenic properties, has been found associated with telomere elongation and haematological ...
Flore Sicre de Fontbrune, Stéphane Jouneau, Vincent Cottin, Grégoire Prevot, Hilario Nunes, Louis Terriou, Sylvain Marchand-Adam, Bruno Crestani, Ambroise Marcais, Anne Bergeron, Marie-Pierre Debray, Aurélie Plessier, Elodie Lainey, Ibrahima Ba, Caroline Kannengiesser, Kristell Desseaux, Matthieu Resche-Rigon, Lucie Biard, Raphael Borie   +18 more
doaj   +2 more sources

Rapid early remission in a patient with severe aplastic anemia: a case report of hetrombopag, cyclosporine, and danazol combination therapy [PDF]

Frontiers in Immunology
Severe aplastic anemia (SAA) is a life-threatening bone marrow failure syndrome that is caused primarily by immune-mediated destruction of hematopoietic stem cells.
Yuting Dai, Qiang Guo, Xiaoxiao Guo, Qiuju Liu   +3 more
doaj   +2 more sources

Therapeutic potential of luteolin in central precocious puberty: insights from a danazol-induced rat model [PDF]

Frontiers in Endocrinology
BackgroundRecently, central precocious puberty (CPP) is becoming a major public health concern worldwide due to its enhanced prevalence. Traditional Chinese medicine (TCM) compounds offer unique therapeutic advantages for treating this condition, and ...
Zhijian Zha, Enze Lei, Xiaofan Wu, Siyu Bai, Tiantian Huang, Tao Lu, Zifeng Wang, Yan Cai, Hui Li, Yao Chen, Yao Chen, Jianzhong Liu, Jianzhong Liu, Jianzhong Liu, Jianzhong Liu   +14 more
doaj   +2 more sources

Application of different methods to predict the lipophilicity parameter of danazol [PDF]

Farmacja Polska, 2021
The aim of this study was to evaluate the applicability of both methods, i.e. reversed-phase thin-layer chromatography (RP-TLC) and high-performance thin-layer chromatography (RP-HPTLC), and computational algorithms to determine the lipophilicity ...
Małgorzata Dołowy, Rafał Sochacki
doaj   +1 more source

No effect of danazol treatment in patients with advanced idiopathic pulmonary fibrosis

ERJ Open Research, 2023
Background Telomere dysfunction can underly the development of idiopathic pulmonary fibrosis (IPF), and recent work suggests that patients with telomere syndromes might benefit from treatment with androgens, such as danazol.
Thijs W. Hoffman, Coline H.M. van Moorsel, Joanne J. van der Vis, Douwe H. Biesma, Jan C. Grutters   +4 more
doaj   +1 more source

Danazol in Refractory Autoimmune Hemolytic Anemia or Immune Thrombocytopenia: A Case Series Report and Literature Review

Pharmaceuticals, 2022
Danazol is a treatment option for autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia (ITP). Three patients with AIHA and eight patients with ITP between 2008 and 2022 were enrolled in the Rheumatology Outpatient Clinic of Chang Gung Memorial ...
Hsu-En Huang, Ko-Ming Lin, Jing-Chi Lin, Yu-Ting Lin, Hsiao-Ru He, Yu-Wei Wang, Shan-Fu Yu, Jia-Feng Chen, Tien-Tsai Cheng   +8 more
doaj   +1 more source