Results 1 to 10 of about 6,348 (189)
No effect of danazol treatment in patients with advanced idiopathic pulmonary fibrosis [PDF]
ERJ Open Research, 2023 Background Telomere dysfunction can underly the development of idiopathic pulmonary fibrosis (IPF), and recent work suggests that patients with telomere syndromes might benefit from treatment with androgens, such as danazol.
Thijs W. Hoffman +4 more
doaj +3 more sources
Delphi Consensus on Attenuated Androgen Use for Long‐Term Prophylaxis in Hereditary Angioedema: AURA Project [PDF]
Clinical and Translational AllergyBackground Danazol and other attenuated androgens (AAs) have been a cornerstone of Hereditary Angioedema (HAE) long‐term prophylaxis (LTP) for decades, alongside intravenous plasma‐derived C1INH (pdC1INH). Danazol's potential androgenic effects, however,
Eunice Dias de Castro +3 more
doaj +2 more sources
Low-dose baricitinib plus danazol in primary immune thrombocytopenia: a randomized, controlled phase 2 trial [PDF]
Nature CommunicationsThis multicenter, randomized, controlled study was conducted to explore the safety and efficacy of low-dose baricitinib plus danazol for ITP patients who had failed corticosteroids and at least one recommended subsequent treatment.
Peng Zhao +32 more
doaj +2 more sources
Pharmaceuticals, 2022 Danazol is a treatment option for autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia (ITP). Three patients with AIHA and eight patients with ITP between 2008 and 2022 were enrolled in the Rheumatology Outpatient Clinic of Chang Gung Memorial ...
Hsu-En Huang +8 more
doaj +2 more sources
Efficacy and safety of danazol for pulmonary fibrosis or bone-marrow failure associated with telomere-related gene mutation [PDF]
ERJ Open ResearchBackground Telomere-related gene (TRG) pathogenic variants are detected in ∼30% of familial pulmonary fibrosis (PF) cases. Danazol, a synthetic sex hormone with androgenic properties, has been found associated with telomere elongation and haematological ...
Flore Sicre de Fontbrune +18 more
doaj +2 more sources
Therapeutic potential of luteolin in central precocious puberty: insights from a danazol-induced rat model [PDF]
Frontiers in EndocrinologyBackgroundRecently, central precocious puberty (CPP) is becoming a major public health concern worldwide due to its enhanced prevalence. Traditional Chinese medicine (TCM) compounds offer unique therapeutic advantages for treating this condition, and ...
Zhijian Zha +14 more
doaj +2 more sources
Application of different methods to predict the lipophilicity parameter of danazol [PDF]
Farmacja Polska, 2021 The aim of this study was to evaluate the applicability of both methods, i.e. reversed-phase thin-layer chromatography (RP-TLC) and high-performance thin-layer chromatography (RP-HPTLC), and computational algorithms to determine the lipophilicity ...
Małgorzata Dołowy, Rafał Sochacki
doaj +1 more source
Frontiers in Medicine, 2021 Background: Stanozolol and danazol are widely used in the treatment of aplastic anemia; however, their mechanisms of action are unclear.Methods: Bone marrow mononuclear cells from 10 patients newly diagnosed with aplastic anemia and 10 healthy volunteers
Hongmin Li +3 more
doaj +1 more source
Plants, 2021 Anemarrhenae rhizome and Phellodendri cortex have historically been used for the treatment of precocious puberty (PP) in oriental medicine. Our study aimed to evaluate the effect of APE, a mixture of the extracts from these herbs, against danazol-induced
Kyeong Ri Kim +9 more
doaj +1 more source
Effects of Letrozole Compared with Danazol on Patients with Confirmed Endometriosis: A Randomized Clinical Trial [PDF]
International Journal of Fertility and Sterility, 2010 Background Letrozole is an aromatase inhibitor which can decrease estrogen production in peripheral tissues and endometriosis. Danazol, as an androgen, inhibits estrogen production in ovaries and recently has been introduced as an aromatase inhibitor ...
Mohamad Ali Roghaei +3 more
doaj +1 more source