Results 11 to 20 of about 16,122 (287)
Successful treatment of telomeropathy‐related interstitial lung disease with immunosuppression and danazol [PDF]
Respirology Case Reports, 2020 We report the case of a 42‐year‐old female with a history of finger clubbing which improved during pregnancy, a history of unexplained hepatosplenomegaly, and subsequent non‐specific interstitial pneumonia with respiratory failure.
Daniel C. Chambers +5 more
doaj +3 more sources
No effect of danazol treatment in patients with advanced idiopathic pulmonary fibrosis
ERJ Open Research, 2023 Background Telomere dysfunction can underly the development of idiopathic pulmonary fibrosis (IPF), and recent work suggests that patients with telomere syndromes might benefit from treatment with androgens, such as danazol.
Thijs W. Hoffman +4 more
doaj +2 more sources
BMJ Open Respiratory Research, 2021 Introduction Recent discoveries have identified shortened telomeres and related mutations in people with pulmonary fibrosis (PF). There is evidence to suggest that androgens, including danazol, may be effective in lengthening telomeres in peripheral ...
Tamera J Corte +19 more
doaj +2 more sources
Scientific Reports, 2019 Multidrug resistance presents an obstacle in cancer treatment. Among numerous combative strategies, collateral sensitivity (CS) drugs have opened a new avenue to defeat cancer by exploiting selective toxicity against multidrug-resistant (MDR) cancer.
Ying-Tzu Chang +6 more
doaj +2 more sources
Biomedicines, 2020 A link between telomere shortening and oxidative stress was found in aging people and patients with cancer or inflammatory diseases. Extracts of Astragalus spp. are known to stimulate telomerase activity, thereby compensating telomere shortening.
Isabelle Guinobert +12 more
doaj +2 more sources
Danazol Treatment for Telomere Diseases
New England Journal of Medicine, 2016 Genetic defects in telomere maintenance and repair cause bone marrow failure, liver cirrhosis, and pulmonary fibrosis, and they increase susceptibility to cancer. Historically, androgens have been useful as treatment for marrow failure syndromes. In tissue culture and animal models, sex hormones regulate expression of the telomerase gene.In a phase 1-2
Barbara Weinstein +17 more
semanticscholar +11 more sources
Evaluating the Efficacy of Levonorgestrel Intrauterine System and Danazol for Relief of Postoperative Pain in Endometriosis [PDF]
Journal of Clinical and Diagnostic Research, 2017 Introduction: Endometriosis is an oestrogen-dependent disorder, manifests during reproductive years and is associated with pain and infertility. There is considerable debate about the effectiveness of various interventions for pain relief.
Ashima Taneja +5 more
doaj +2 more sources
Future Oncology, 2021 Hallmark features of myelofibrosis (MF) are cytopenias, constitutional symptoms and splenomegaly. Anemia and transfusion dependency are among the most important negative prognostic factors and are exacerbated by many JAK inhibitors (JAKi).
Srđan Verstovšek +20 more
openalex +2 more sources
Fertility and Sterility, 1978 Danazol, a synthetic 2,3-isoxazol derivative of 17 alpha-ethinyltestosterone, was administered to healthy nonpregnant volunteers to determine wheter a luteolytic effect could be detected by observation of cycle length, duration of the luteal rise, and luteal steroidogenesis. Danazol administration resulted in a decreased duration of the luteal rise and
Karan C. Sapp, Anne Colston Wentz
openaire +4 more sources
Turkish Journal of Hematology, 2013 OBJECTIVE: The responses of 32 patients with paroxysmal nocturnal hemoglobinuria (PNH) were assessed after the patients were put on various combinations of danazol, prednisolone, and cyclosporine.
Kanjaksha Ghosh +3 more
doaj +2 more sources