Results 1 to 10 of about 50,688 (149)
Transient autoantibodies to danger signals [PDF]
Frontiers in Immunology, 2023 The Danger Model predicts that there are some molecules that no immune system can ever be fully tolerant of, namely proteins that are only transiently expressed during times of stress, infection, or injury.
Elana R. Shaw, Polly Matzinger
doaj +4 more sources
Danger Signals in Cardiovascular Disease [PDF]
Mediators of Inflammation, 2014 More than ten years ago, the “danger theory” challenged conservative immunology. At that time, the consensus was that the immune system is activated by antigens recognized as nonself. However, the self-nonself theory gave no explanation why, for example, a fetus with obvious foreign antigens does not lead to maternal immune activation whereas ...
Stefan Frantz +2 more
doaj +7 more sources
DAMPening COVID-19 Severity by Attenuating Danger Signals [PDF]
Frontiers in Immunology, 2021 COVID-19 might lead to multi-organ failure and, in some cases, to death. The COVID-19 severity is associated with a “cytokine storm.” Danger-associated molecular patterns (DAMPs) are proinflammatory molecules that can activate pattern recognition ...
Luis A. Silva-Lagos +5 more
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The Delivery of Extracellular “Danger” Signals to Cytosolic Sensors in Phagocytes [PDF]
Frontiers in Immunology, 2022 Phagocytes, such as macrophages and dendritic cells, possess the ability to ingest large quantities of exogenous material into membrane-bound endocytic organelles such as macropinosomes and phagosomes.
Gerone A. Gonzales +2 more
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Glycolysis-induced drug resistance in tumors—A response to danger signals? [PDF]
Neoplasia: An International Journal for Oncology Research, 2021 Tumor cells often switch from mitochondrial oxidative metabolism to glycolytic metabolism even under aerobic conditions. Tumor cell glycolysis is accompanied by several nonenzymatic activities among which induction of drug resistance has important ...
Fabrizio Marcucci, Cristiano Rumio
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COVID-19 Vaccination Limits Systemic Danger Signals in SARS-CoV-2 Infected Patients [PDF]
Viruses, 2022 Vaccination with an mRNA COVID-19 vaccine determines not only a consistent reduction in the risk of SARS-CoV-2 infection but also contributes to disease attenuation in infected people.
Roberta Angioni +8 more
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TH17 cells promote CNS inflammation by sensing danger signals via Mincle [PDF]
Nature Communications, 2022 Mincle is a pattern recognition receptor that senses danger signals in innate immune cells. Here authors show in an experimental autoimmune encephalomyelitis mouse model that tissue damage triggers Mincle signaling on inflammatory helper T cells, leading
Quanri Zhang +16 more
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Danger signals in trauma. [PDF]
Eur J Trauma Emerg Surg, 2018 This review summarizes a short list of currently discussed trauma-induced danger-associated molecular patterns (DAMP). Due to the bivalent character and often pleiotropic effects of a DAMP, it is difficult to describe its "friend or foe" role in post-traumatic inflammation and regeneration, both systemically as well locally in tissues. DAMP can be used
Relja B, Mörs K, Marzi I.
europepmc +6 more sources
Staphylococcal Superantigens Spark Host-Mediated Danger Signals [PDF]
Frontiers in Immunology, 2016 Staphylococcal enterotoxin B (SEB) of Staphylococcus aureus, and related superantigenic toxins produced by myriad microbes, are potent stimulators of the immune system causing a variety of human diseases from transient food poisoning to lethal toxic ...
Terry eKrakauer +2 more
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Danger signals and graft-versus-host disease: Current understanding and future perspectives [PDF]
Frontiers in Immunology, 2016 Graft-versus-host response after allogeneic hematopoietic stem cell transplantation (allo-HCT) represents one of the most intense inflammatory responses observed in humans.
Tomomi Toubai +3 more
doaj +2 more sources