Results 31 to 40 of about 50,688 (149)
Heat shock proteins as danger signals for cancer detection
Frontiers in Oncology, 2011 First discovered in 1962, heat shock proteins (HSPs) are highly studied with about 35,500 publications on the subject to date. HSPs are highly conserved, function as molecular chaperones for a large panel of client proteins and have strong cytoprotective
Renaud eSeigneuric +12 more
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Danger Signals Activating the Immune Response after Trauma
Mediators of Inflammation, 2012 Sterile injury can cause a systemic inflammatory response syndrome (SIRS) that resembles the host response during sepsis. The inflammatory response following trauma comprises various systems of the human body which are cross-linked with each other within
Stefanie Hirsiger +4 more
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Cell Death Discovery, 2022 Acute kidney injury (AKI) is characterized by necroinflammation formed by necrotic tubular epithelial cells (TECs) and interstitial inflammation. In necroinflammation, macrophages are key inflammatory cells and can be activated and polarized into ...
Chongbin Liu +3 more
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ROLE OF PURINERGIC RECEPTORS IN IMMUNE RESPONSE
Журнал микробиологии, эпидемиологии и иммунобиологии, 2016 Purine receptors are located on immune and somatic cells of animal and human organisms. Summation of signals from purine and TOLL-like receptors takes place on the level of inflammasome formation and results in summation of the first and second signals ...
I. B. Semenova
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Molecular pathways of pannexin1-mediated neurotoxicity
Frontiers in Physiology, 2014 Pannexin1 (Panx1) forms nonselective membrane channels, structurally similar to gap junction hemichannels, that is permeable to ions, nucleotides and other small molecules below 900 Da. Panx1 activity is implicated in paracrine signaling and inflammasome
Valery I. Shestopalov +4 more
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Training discrimination diminishes maladaptive avoidance of innocuous stimuli in a fear conditioning paradigm. [PDF]
PLoS ONE, 2017 Anxiety disorders are the most common mental disorder worldwide. Although anxiety disorders differ in the nature of feared objects or situations, they share a common mechanism by which fear generalizes to related but innocuous objects, eliciting ...
Miriam J J Lommen +5 more
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Various forms of tissue damage and danger signals following hematopoietic stem cell transplantation
Frontiers in Immunology, 2015 Hematopoietic stem cell transplantation (HSCT) is the most potent curative therapy for many malignant and non-malignant disorders. Unfortunately, a major complication of HSCT is graft-versus-host disease (GVHD), which is mediated by tissue damage ...
Abdulraouf eRamadan, Sophie ePaczesny
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Platelet Inflammatory Response to Stress
Frontiers in Immunology, 2019 Blood platelets play a central hemostatic role, (i) as they repair vascular epithelial damage, and (ii) they play immune defense roles, as they have the capacity to produce and secrete various cytokines, chemokines, and related products.
Fabrice Cognasse +14 more
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Journal of Translational Medicine, 2011 Background Trauma is one of the leading causes of death in young adult patients. Many pre-clinical and clinical studies attempt to investigate the immunological pathways involved, however the true mediators remain to be elucidated.
Porterfield Nancy +4 more
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The Dichotomous Responses Driven by β-Defensins
Frontiers in Immunology, 2020 Defensins are short, rapidly evolving, cationic antimicrobial host defence peptides with a repertoire of functions, still incompletely realised, that extends beyond direct microbial killing.
Jennifer R. Shelley +2 more
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