Results 31 to 40 of about 21,225 (193)

Estudo dos Genes Relacionados a Mecanismos de Reparo em Danos de DNA em Síndrome Mielodisplásica

Revista Brasileira de Cancerologia, 2013
Introdução: A síndrome mielodisplásica (SMD) e um grupo de doenças clonais das células tronco hematopoiéticas (HSC) caracterizadas por citopenia periférica, displasia em linhagens mieloides e aumento do risco de desenvolvimento para leucemia mieloide ...
Howard Lopes Ribeiro Junior, Ronald Feitosa Pinheiro   +1 more
doaj   +1 more source

Avaliação do efeito modulador de diferentes estatinas sobre danos ao DNA induzidos pela doxorrubicina em células somáticas de Drosophila melanogaster [PDF]

, 2021
Statins are antilipemics drugs that promote inhibition of HMG-CoA reductase, an essential enzyme in the cholesterol biosynthetic pathway. Besides inhibiting cholesterol synthesis, can also inhibit the formation of other products, such as isoprenoids, which confers additional benefits this class of drugs, among which, antiproliferative, anti-invasive ...
openaire   +2 more sources

Oxidative DNA damage induced by S(IV) in the presence of Cu(II) and Cu(I) complexes [PDF]

The DNA damage induced by S(IV) in the presence of some Cu(II) complexes in air saturated solution was investigated. The addition of S(IV) to an air saturated solution containing CuII GGA (GGA = glycylglycyl-L-alanine), CuII G3 (G3 = triglycine) or CuII ...
ALIPÁZAGA, María V., CERCHIARO, Giselle, COICHEV, Nina, MOYA, Horácio D.   +3 more
core   +1 more source

Comparisons of the effects of the sevoflurane and propofol on acute ischemia reperfusion and DNA damages in rabbits

Brazilian Journal of Anesthesiology, 2017
Background and objectives: The aim of this study was to compare the effects of sevoflurane and propofol anesthesia on oxidative DNA damage that occurs in low-extremity ischemia and is caused by tourniquet application.
Sema Oncul, Lale Karabiyik, Erdem Coskun, Ela Kadioglu, Ozlem Gulbahar   +4 more
doaj   +1 more source

Systemic lupus erythematosus (SLE): clinical and laboratory profile of patients followed at the Onofre Lopes University Hospital (UFRN - Natal/Brazil) and early organ damage in patients with recently diagnosed disease [PDF]

, 2005
OBJECTIVE: to analyse clinical and laboratory features of patients with systemic lupus erythematosus (SLE), and to describe the early damage outcome of SLE patients in recent onset disease.
Barbosa, Olívia De Fátima Costa, Bezerra, Elaine Lira Medeiros, Castro, Milena De Araújo, Santos, Sílvia Queiroz, Sato, Emilia Inoue, Trindade, Marília Cavalcanti Da, Vilar, Maria José Pereira   +6 more
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Assessment of genotoxicity and depuration of anthracene in the juvenile coastal fish Trachinotus carolinus using the comet assay

Brazilian Journal of Oceanography, 2013
In the environment, anthracene is characterized as being persistent, bioaccumulative and toxic to aquatic organisms. Biotransformation of xenobiotic substances, such as anthracene, produces reactive oxygen species that may induce DNA strand breaks.
Fabio Matsu Hasue, Maria José de Arruda Campos Rocha Passos, Thaís da Cruz Alves dos Santos, Arthur José da Silva Rocha, Caroline Patrício Vignardi, Priscila Verônica Sartorio, Vicente Gomes, Phan Van Ngan   +7 more
doaj   +1 more source

Danos ao DNA promovidos por ácido 5-aminolevulínico: possível associação com o desenvolvimento de carcinoma hepatocelular em portadores de porfiria aguda intermitente [PDF]

Química Nova, 2002
5-Aminolevulinic acid (ALA) is a heme precursor accumulated in acute intermittent porphyria (AIP), which might be associated with hepatocellular carcinoma (HCC) in symptomatic patients. Under metal catalyzed oxidation, ALA and its cyclic dimerization product, 3,6-dihydropyrazine-2,5-dipropanoic acid, produce reactive oxygen species that damage plasmid ...
Onuki, Janice, Teixeira, Priscila C., Medeiros, Marisa H.G., Di Mascio, Paolo   +3 more
openaire   +4 more sources

Ação antioxidante de Coffea arabica cultivar mundo novo IAC 388-17 em diferentes graus de torra. [PDF]

, 2011
O café é uma das bebidas mais consumidas no Brasil e no mundo, e sua produção agrícola está intimamente ligada com a economia global. Neste caso, é fundamental o conhecimento profundo da sua relação com a saúde, bem-estar e a fisiologia dos seres humanos.
BANDEIRA, T. A. F. P., CAMPOS, E. G., GAPARI-PEZZOPANE, C., MALUF, M. P., POLEZ, V. L. P., ROSA, D. L., SILVA, A. C. da, TIMBÓ, R. V.   +7 more
core  

Application of Comet assay to assess the effects of white bean meal on DNA of human lymphocytes

Brazilian Journal of Pharmaceutical Sciences, 2012
This study was conducted to evaluate the potential induction of genotoxic effects of white bean flour using the Comet assay. The test was conducted with human lymphocytes present in whole blood immediately after collection, by incubation with white bean ...
Luciana Lopes Silva Pereira, Silvana Marcussi, Lívia Cabral Sátiro, Chrystian Araujo Pereira, Larissa Fonseca Andrade, Lisete Chamma Davide, Custódio Donizete dos Santos   +6 more
doaj   +1 more source

VIREMIA DE BK: ANÁLISE QUANTITATIVA EM PACIENTES TRANSPLANTADOS EM HOSPITAL TERCIÁRIO NO SUL DO BRASIL

Brazilian Journal of Infectious Diseases, 2023
Introdução/objetivo: O poliomavírus BK (BKV) é um vírus de dupla fita de DNA pertencente à família Polyomaviridae. Estima-se que 80-90% da população adulta seja soropositiva para BKV, ficando em fase latente no organismo após infecção primária que, em ...
Alessandra Helena da Silva Hellwig, William Latosinski Matos, Luciana Giordani, Grazielle Motta Rodrigues, Viviane Horn de Melo, Juliana Bergmann, Sofia Aquino Monteiro, Angela dos Santos Azevedo, Elisa Costabeber, Fernanda de-Paris, Dariane Castro Pereira, Rodrigo Minuto Paiva, Afonso Luís Barth   +12 more
doaj   +1 more source