Results 51 to 60 of about 5,900 (176)

Effects of Danshen injection on iron levels in kidney homogenates.

, 2013
Iron levels were measured in kidney homogenates of control, iron overload, DFO, H-Danshen and L-Danshen groups.
Li Chu (459196), Yonggang Gao (459194), Na Wang (193263), Xuan Zhang (56049), Juanjuan Ma (459193), Jiangyan Wang (459195), Yun Xie (293668), Shengjiang Guan (459192), Jianping Zhang (161794), Ying Zhang (40767), Yuanyuan Zhang (101797)   +10 more
core   +1 more source

Simultaneous Determination of Seven Bioactive Constituents from Salvia miltiorrhiza in Rat Plasma by HPLC-MS/MS: Application to a Comparative Pharmacokinetic Study

Separations, 2021
The roots of Salvia miltiorrhiza (Danshen) is a precious herbal medicine used to treat cardiovascular diseases. This study establishes a high-performance liquid chromatography-tandem mass spectrometric (HPLC-MS/MS) method to quantify seven bioactive ...
Yanli Zhang, Weiliang Cui, Xianghong Liu, Ning Wang, Wenru Kong, Junyu Sui, Huifen Li, Shuqi Wang   +7 more
doaj   +1 more source

The Role of Inflammation and Immunity in Cardiovascular Disease: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
Inflammation in cardiovascular disease is a dynamic and context‐dependent network rather than a secondary response to injury. Mitochondrial danger signaling links metabolic stress to immune activation through TLR priming, NLRP3 inflammasome amplification, cGAS–STING signaling, and immunometabolic gating, providing a basis for more precise therapeutic ...
Jiaxiang Rong, Zhen Wang, Xiaoxiao Lin, Ziwen Lei, Qianqian Huang, Hang Liu, Fei Luan, Junbo Zou, Yajun Shi   +8 more
wiley   +1 more source

The mechanisms by which Yiqi Huoxue compound treats pulmonary inflammation and fibrosis in scleroderma: Based on bioinformatics and network pharmacology

Pifu-xingbing zhenliaoxue zazhi
Objective To identify the effective components and key molecules of Yiqi Huoxu compound(YQHX) in the treatment of pulmonary inflammation and fibrosis in scleroderma, providing basis for the development of drug targets for scleroderma.
Menghua HU, Qiaorui TAN, Weilin PU, Min DU, Wenzhen TU, Dayan SUN, Jingyi YANG, Yifei GU, Jiucun WANG, Xiangzhen KONG   +9 more
doaj   +1 more source

Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy

Phytotherapy Research, Volume 40, Issue 8, Page 4759-4791, August 2026.
Natural compounds act on key cellular pathways in psoriasis by suppressing keratinocyte hyperproliferation, modulating Th17/IL‐17‐mediated immune responses, and reducing oxidative stress. These multi‐target effects highlight their potential as safer adjunctive therapies alongside conventional treatments.
Hye Jin Lee, Yu Jin So, Il‐Joo Jo, Ji Yong Jang, Tae Han Yook, Jun Ho Lee, Sung Wook Kim, Kangwook Lee, Soo Jung Park, Gabsik Yang   +9 more
wiley   +1 more source

The effect of Danshen extract on lipoprotein-associated phospholipase A2 levels in patients with stable angina pectoris: study protocol for a randomized controlled trial - the DOLPHIN study

Trials, 2017
Background Lipoprotein-associated phospholipase A2 (Lp-PLA2), a biomarker of oxidation and inflammation, has been associated with increased coronary artery disease risk.
A-Di Chen, Chun-Ling Wang, Yang Qin, Liang Tian, Li-Bin Chen, Xiao-Ming Yuan, Lin-Xiu Ma, Yu-Feng Wang, Ji-Rong Sun, Hao-Sen Wang, Neng Dai, DOLPHIN investigator group   +11 more
doaj   +1 more source

Exploring the Potential Mechanism of Danshen in the Treatment of Concurrent Ischemic Heart Disease and Depression Using Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation

Natural Product Communications, 2022
Objective: This study aimed to explore the potential targets and mechanism of action of Danshen in treating concurrent ischemic heart disease (IHD) and depression using network pharmacology, molecular docking, and molecular dynamics simulation (MDS ...
Zhiyao Liu, Hailiang Huang, Ying Yu, Yuqi Jia, Xiaowen Dang, Yajie Wang, Lei Huang   +6 more
doaj   +1 more source

Cross‐stage single‐cell and spatial metabolome analyses reveal periderm specialization and tanshinone biosynthesis in Salvia miltiorrhiza roots

New Phytologist, Volume 251, Issue 3, Page 1267-1282, August 2026.
Biosynthesis and accumulation of tanshinones in the periderm of Salvia miltiorrhiza during secondary root growth. Summary Perennial herbs develop long‐lived roots that undergo repeated cycles of secondary growth, during which the periderm functions as a protective barrier and a major site of specialized metabolite accumulation.
Licheng Liu, Lianchong Gao, Zhi‐Ying Wang, Yan Liu, Huifeng Ju, Huana Lin, Zheng Shi, Wen‐Juan Cai, Xue Li, Yan‐Bo Huang, Yu Kong, Jing‐Jing Xu, Hong‐Peng Chen, Xin Fang, Juan Guo, Yong‐Hong Hu, Ke Chen, Xiao‐Ya Chen, Jie Hao, Lei Yang   +19 more
wiley   +1 more source

Salvianolic Acid B Upregulates miR‐744‐5p Expression in Peripheral Blood Mononuclear Cell–Derived Extracellular Vesicles to Alleviate Uremic Cardiomyopathy

Journal of Extracellular Vesicles, Volume 15, Issue 7, July 2026.
Uremic cardiomyopathy (UCM) is a life‐threatening complication of uremia. We find that extracellular vesicle (EV)‐miR‐744‐5p mediates peripheral blood mononuclear cell (PBMC)‐cardiomyocyte communication in UCM. Salvianolic acid B treats UCM by modulating EV‐miR‐744‐5p expression.
Ziran Wang, Jiaojiao Hao, Yaxi Shang, Wenli Ma, Nan Wang, Weidong Wang, Qingzhu Tang, Xiangning Du, Fan Yang, Biaojie Qin, Shuni Chen, Kun Xiao, Longkai Li, Xianan Guo, Xin Qi, Shuang Meng, Huiyi Song, Hongli Lin   +17 more
wiley   +1 more source

Advances in pharmacotherapy for vascular cognitive impairment and vascular dementia: An update of 2025

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 3, July/September 2026.
Abstract Vascular cognitive impairment (VCI), including vascular dementia (VaD), encompasses a spectrum of cognitive deficits resulting from cerebrovascular pathology, ranging from mild impairment to dementia. As the second leading cause of dementia worldwide, VCI remains a major therapeutic challenge.
Doan‐Khanh Tran, Yi‐Chun Kuan, Li‐Kai Huang, Chaur‐Jong Hu   +3 more
wiley   +1 more source