CaMKII inhibition rectifies arrhythmic phenotype in a patient-specific model of catecholaminergic polymorphic ventricular tachycardia [PDF]
, 2013 Induced pluripotent stem cells (iPSC) offer a unique opportunity for developmental studies, disease modeling and regenerative medicine approaches in humans.
Avelino-Cruz, JE +11 more
core +1 more source
A Scoping Review of the Oral Treatment Options for the Management of Detrusor Sphincter Dyssynergia
Neurourology and Urodynamics, Volume 44, Issue 4, Page 743-753, April 2025.ABSTRACT Background Adult neurogenic lower urinary tract dysfunction may be associated with detrusor sphincter dyssynergia (DSD). Given the sparsity of the literature and the absence of official guidelines regarding the use of oral medications in the management of DSD, this scoping review aims to critically assess the available evidence to guide future
Angélique Tousignant +4 more
wiley +1 more source
Pharmacology Research &Perspectives, Volume 13, Issue 2, April 2025.At high concentrations (> 10 μM), the β‐adrenergic blocker propranolol paradoxically increased intracellular cAMP levels in pancreatic β‐cells. This led to PKA‐induced RYR2 phosphorylation and extracellular Ca2+ influx, leading to CICR from the ER. CICR activated TRPM5, which augmented β‐cell electrical activity, extracellular Ca2+ influx, and insulin ...
Naoya Murao +6 more
wiley +1 more source
Study on contraction and relaxation of experimentally denervated and immobilized muscles: Comparison with dystrophic muscles [PDF]
The contraction-relaxation mechanism of experimentally denervated and immobilized muscles of the rabbit is examined. Results are compared with those of human dystrophic muscles, in order to elucidate the role and extent of the neurotrophic factor, and ...
Hazama, R. +4 more
core +1 more source
Patterning of wound-induced intercellular Ca2+ flashes in a developing epithelium [PDF]
, 2015 Differential mechanical force distributions are increasingly recognized to provide important feedback into the control of an organ's final size and shape.
Alexander Fletcher +15 more
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Pharmacological interventions other than botulinum toxin for spasticity after stroke. [PDF]
, 2016 BACKGROUND: The long-term risk of stroke increases with age, and stroke is a common cause of disability in the community. Spasticity is considered a significantly disabling impairment that develops in people who have had a stroke.
Kouzouna, A +3 more
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Role of Go/i subgroup of G proteins in olfactory signaling of Drosophila melanogaster. [PDF]
, 2014 Intracellular signaling in insect olfactory receptor neurons remains unclear, with both metabotropic and ionotropic components being discussed. Here, we investigated the role of heterotrimeric Go and Gi proteins using a combined behavioral, in vivo and ...
Galizia, C.G. +3 more
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Complex management of a patient with refractory primary erythromelalgia lacking a SCN9A mutation
Journal of Pain Research, 2017 Sarah A Low,1 Wendye Robbins,2,3 Vivianne L Tawfik2 1Department of Internal Medicine, Banner University Medical Center, University of Arizona College of Medicine, Tucson, AZ, 2Department of Anesthesiology, Perioperative & Pain Medicine, Stanford ...
Low SA, Robbins W, Tawfik VL
doaj
Scientific ReportsAn experimental design and response surface methodologies using Plackett–Burman and Box-Behnken designs were applied for selecting and optimizing the most appropriate parameters which significantly affect the separation and quantitative estimation of ...
Ayoub N. Mozayad +2 more
doaj +1 more source
The inotropic consequences of selective Na+/Ca2+ exchanger inhibition is controlled by the actual transport balance [PDF]
, 2018 The major goal of the cardiac Ca2+ handling is to control the actual magnitude and kinetics of the cell contractions and therefore contribute to the regulation of the cardiac output.
Antonio Aguilar +8 more
core +5 more sources