Results 191 to 200 of about 1,049,929 (258)

Synthesis and pharmacological properties of dantrolene and sodium dantrolene

Pharmaceutical Chemistry Journal, 1984
AbstractDer Aldehyd (I) reagiert mit Aminohydantoin (II) zu Dantrolen (III), aus dem mit Natrium‐methylat das Natrium‐Salz (IV) erhalten wird.
R. D. Syubaev, T. I. Vozyakova, S. M. Golovina, A. F. Oleinik, N. I. Andreeva   +4 more
openaire   +3 more sources

In vitroantioxidant properties of dantrolene sodium

Pharmacological Research, 2001
Dantrolene sodium is a skeletal muscle relaxant, which inhibits intracellular Ca2+ release from the sarcoplasmic reticulum. The aim of this study is to examine possible in vitro antioxidant effects of dantrolene sodium. For this reason, the in vitro antioxidant effects of dantrolene sodium were studied using thiocyanate methods.
BUYUKOKUROGLU, Mehmet Emin, OKTAY, Münir, KUFREVIOGLU, Ömer İrfan, Gulcin, I   +3 more
openaire   +4 more sources

Different Stability Indicating Chromatographic Methods for Specific Determination of Paracetamol, Dantrolene Sodium, Their Toxic Impurities, and Degradation Products.

Biomedical chromotography, 2019
A well-known analgesic [paracetamol (PAR)] and skeletal muscle relaxant [Dantrolene sodium (DNS)] have been analyzed without interference from their toxic impurities and degradation products. The studied PAR impurities are the genotoxic and nephrotoxic p-
N. Abdelwahab, M. M. Abdelrahman, John M Boshra, A. A. Taha   +3 more
semanticscholar   +1 more source

Phenelzine Overdose Treated With Dantrolene Sodium

JAMA: The Journal of the American Medical Association, 1986
THE INGESTION of a monoamine oxidase (MAO) inhibitor can induce a complex array of hypermetabolic signs, including hyperpyrexia, tachycardia, generalized muscle rigidity, tachypnea, metabolic acidosis, hypoxemia, and hypercapnia 1 (J. W. Katalavis, MD, oral communication, November 1984).
Will Webster, Stephen Mudra, Neil G. Feinglass, Richard F. Kaplan   +3 more
openaire   +3 more sources

Dantrolene Sodium: Effects on Crustacean Muscle

Canadian Journal of Physiology and Pharmacology, 1974
The effect of dantrolene sodium, a muscle relaxant effective on vertebrate skeletal muscle, has been studied on the stretcher muscle of a crab (Callinectes sapidus). The drug rapidly and reversibly attenuates the muscle contractile response to direct and indirect stimulation.
H. L. Atwood, L. L. Odette
openaire   +3 more sources

Successful Treatment Without Using Dantrolene Sodium on a Child Occurring Malignant Hyperthermia During Induction of General Anesthesia: A Case Report.

The Journal of craniofacial surgery (Print)
Malignant hyperthermia (MH) is a fatal hyperthermia with a high mortality, which usually occurs during induction of general anesthesia. Dantrolene sodium is a wonder drug currently used for treating malignant hyperthermia.
Qiaoyuan Zheng, Na Liu, Yang Zeng, Yuan Chen, Huiwen Zhang, Xueshang Su, Jun Zhuang   +6 more
semanticscholar   +1 more source

Determination and tissue distribution studies of dantrolene sodium with hydroxypropyl-β-cyclodextrin in rat tissue by HPLC/MS/MS.

Biomedical chromotography, 2019
The established analytical method for determining the concentration of Dantrolene sodium (Da) in rat tissues by HPLC/MS/MS technique was successfully applied to the tissue distribution studies of Da in rats.
Ruixue Liu, Yu Chen, Shengjie Zhao, Min Zhao, Chunjie Zhao, Miao Wang   +5 more
semanticscholar   +1 more source

Effect of Dantrolene Sodium in Myotonic Dystrophy

European Neurology, 1983
The effect of dantrolene sodium, using a dosage of 120 mg/day, was investigated in 3 patients suffering from myotonic dystrophy. These patients showed a marked reversible deterioration of the clinical symptoms, caused by a reduction of the isometric strength.
P Dal-Bianco, K Zeitlhofer, B Mamoli
openaire   +2 more sources

85-LB: A Phase 1b/2 Clinical Trial of Dantrolene Sodium in Patients with Wolfram Syndrome

Diabetes, 2019
Wolfram syndrome is a rare, progressive neurodegenerative disorder characterized by juvenile-onset diabetes, optic nerve atrophy and mutation of the WFS1 gene.
Damien Abreu, T. Pearson, R. Bucelli, A. Simpson, Cris M. Brown, Kelly Kries, Hongjie Gu, Stephen I. Stone, L. Tychsen, G. V. Stavern, N. White, B. Marshall, T. Hershey, F. Urano   +13 more
semanticscholar   +1 more source

Dantrolene sodium increases calcium binding by human recombinant cardiac calsequestrin and calcium loading by sheep cardiac sarcoplasmic reticulum

Acta Physiologica, 2019
Dantrolene interacts with ryanodine receptors in skeletal and cardiac muscle affecting sarcoplasmic reticulum calcium release. Since dantrolene is lipophilic it could also affect intra‐sarcoplasmic reticulum calcium handling proteins such as ...
Christine M. Loescher, L. M. Gibson, D. Stephenson   +2 more
semanticscholar   +1 more source