Results 191 to 200 of about 1,064,868 (260)

85-LB: A Phase 1b/2 Clinical Trial of Dantrolene Sodium in Patients with Wolfram Syndrome

Diabetes, 2019
Wolfram syndrome is a rare, progressive neurodegenerative disorder characterized by juvenile-onset diabetes, optic nerve atrophy and mutation of the WFS1 gene.
Damien Abreu, T. Pearson, R. Bucelli, A. Simpson, Cris M. Brown, Kelly Kries, Hongjie Gu, Stephen I. Stone, L. Tychsen, G. V. Stavern, N. White, B. Marshall, T. Hershey, F. Urano   +13 more
semanticscholar   +1 more source

Successful Treatment Without Using Dantrolene Sodium on a Child Occurring Malignant Hyperthermia During Induction of General Anesthesia: A Case Report.

The Journal of craniofacial surgery (Print)
Malignant hyperthermia (MH) is a fatal hyperthermia with a high mortality, which usually occurs during induction of general anesthesia. Dantrolene sodium is a wonder drug currently used for treating malignant hyperthermia.
Qiaoyuan Zheng, Na Liu, Yang Zeng, Yuan Chen, Huiwen Zhang, Xueshang Su, Jun Zhuang   +6 more
semanticscholar   +1 more source

Dantrolene sodium increases calcium binding by human recombinant cardiac calsequestrin and calcium loading by sheep cardiac sarcoplasmic reticulum

Acta Physiologica, 2019
Dantrolene interacts with ryanodine receptors in skeletal and cardiac muscle affecting sarcoplasmic reticulum calcium release. Since dantrolene is lipophilic it could also affect intra‐sarcoplasmic reticulum calcium handling proteins such as ...
Christine M. Loescher, L. M. Gibson, D. Stephenson   +2 more
semanticscholar   +1 more source

Dantrolene sodium (dantrium)

Drug and Therapeutics Bulletin, 1976
Dantrolene sodium (Dantrium - Eaton) has been advertised as a muscle relaxant for patients with spasticity, with claims that it is ‘the only direct-acting antispastic agent’.
openaire   +3 more sources

Pharmacokinetics of dantrolene sodium in horses

Journal of Veterinary Pharmacology and Therapeutics, 1987
The pharmacokinetics of dantrolene sodium were investigated in horses following both intravenous (2 mg/kg) and intragastric (4 mg/kg) administration. Two ponies also received dantrolene sodium intravenously (2 mg/kg) in a pilot study to obtain preliminary kinetic data and to determine urinary and biliary excretion of the intact drug.
M H, Court, L R, Engelking, N H, Dodman, M S, Anwer, D C, Seeler, M, Clark   +5 more
openaire   +2 more sources

Dantrolene Sodium: Effects on Crustacean Muscle

Canadian Journal of Physiology and Pharmacology, 1974
The effect of dantrolene sodium, a muscle relaxant effective on vertebrate skeletal muscle, has been studied on the stretcher muscle of a crab (Callinectes sapidus). The drug rapidly and reversibly attenuates the muscle contractile response to direct and indirect stimulation.
L L, Odette, H L, Atwood
openaire   +2 more sources

Dantrolene sodium: Effects of smooth muscle

European Journal of Pharmacology, 1978
The effects of dantrolene sodium on smooth muscle were evaluated in vitro using the guinea pig ileum and the guinea pig vas deferens preparations. Dantrolene irreversibly decreased the strength of the responses of the ileum to acetylcholine, histamine, potassium chloride and electrical stimulation.
S, Graves, K L, Dretchen, G O, Kruger
openaire   +2 more sources

In vitroantioxidant properties of dantrolene sodium

Pharmacological Research, 2001
Dantrolene sodium is a skeletal muscle relaxant, which inhibits intracellular Ca2+ release from the sarcoplasmic reticulum. The aim of this study is to examine possible in vitro antioxidant effects of dantrolene sodium. For this reason, the in vitro antioxidant effects of dantrolene sodium were studied using thiocyanate methods.
BUYUKOKUROGLU, Mehmet Emin, OKTAY, Münir, KUFREVIOGLU, Ömer İrfan, Gulcin, I   +3 more
openaire   +3 more sources

Dantrolene sodium and hepatic injury

Neurology, 1990
This is a report on hepatic adverse events associated with dantrolene therapy. All cases reported to the manufacturer are included, from all sources, through 1987. Of 122 cases containing sufficient data to analyze, 47 patients had asymptomatic transaminase elevations, 12 had additional mild (less than or equal to 2.5 mg/dl) hyperbilirubinemia, 36 had ...
openaire   +2 more sources

Effect of Dantrolene Sodium in Myotonic Dystrophy

European Neurology, 1983
The effect of dantrolene sodium, using a dosage of 120 mg/day, was investigated in 3 patients suffering from myotonic dystrophy. These patients showed a marked reversible deterioration of the clinical symptoms, caused by a reduction of the isometric strength.
B, Mamoli, P, Dal-Bianco, K, Zeitlhofer
openaire   +2 more sources