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A form of chorea that responds to dantrolene sodium
Neurology, 1979Dantrolene sodium is an effective agent for the treatment of congenital chorea in patients with hemiatrophy.
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Interaction of dantrolene sodium with human serum albumin
Journal of Pharmaceutical Sciences, 1976The binding of dantrolene sodium to human serum albumin was studied by fluorescence quenching and difference spectrophotometry. The association constant was calculated from each method of measurement and was large. This binding affinity may be of importance in the clinical setting, since competitive displacement of anionic drug by concurrently ...
J.J. Vallner +2 more
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Effect of Dantrolene Sodium on Spasticity Associated with Hemiplegia†
Journal of the American Geriatrics Society, 1975ABSTRACTThe effects of dantrolene sodium (Dantrium) were studied in 23 patients with hemiplegic spasticity, 13 of whom were younger than 50, and 10 older than 50. The dosage of dantrolene ranged from 100 mg per day initially to 600 mg per day maximally.
Karen L. Ferguson, Franz U. Steinberg
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The Effect of Hypertonic Sodium and Dantrolene on Propranolol Cardiotoxicity
Academic Emergency Medicine, 1997ABSTRACTObjective:To evaluate whether measures that lower cytosolic calcium (Ca) can reverse propranolol (prop) toxicity in the isolated, perfused rat heart.Methods:Isolated rat hearts were perfused on a Langendorff apparatus with Krebs‐Henseleit‐bicarbonate (KHB) buffer solution.
Christian Tomaszewski +3 more
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The action of dantrolene sodium on the lobster neuromuscular junction
Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 1979Abstract 1. At a concentration of 2.3 to 3.1 × 10−5 M, dantrolene Na increased the frequency of stimulation required to elicit a visible muscle contraction from 7 stimuli/sec to a minimum of 25 stimuli/sec. 2. At the same concentration, dantrolene Na had no effect on the following pre- and post-synaptic parameters at the neuromuscular junction of ...
Carol A. Colton, Joel S. Colton
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Effect of dantrolene sodium on canine bladder contractility
Urology, 1980Dantrolene sodium (Dantrium) is currently used in the treatment of detrusorstriated sphincter dyssynergia and is thought to act primarily on striated muscle. The effect of this agent on smooth muscle in general is controversial, and its effect on urinary bladder smooth muscle in particular is not known. In an in vitro muscle bath system, dantrolene was
George S. Benson, Joseph D. Harris
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Dantrolene sodium: Effects on isolated cardiac tissues
Journal of Molecular and Cellular Cardiology, 1983The effects of dantrolene sodium on dog Purkinje fibers, cat atrial and ventricular muscles were studied. Action potential duration was significantly increased and contractility was significantly decreased by dantrolene in all three types of tissue.
José Jalife +2 more
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Evaluation of a Muscle Relaxant: Dantrolene Sodium (Dantrium)
JAMA: The Journal of the American Medical Association, 1975Dantrolene sodium (Dantrium) is a skeletal muscle relaxant, unique in that it acts on the muscle itself. It should be considered for use in patients with skeletal muscle spasticity who are in a stable neurological state. After careful adjustment of the dose, a substantial number of such patients will experience one or more of the following benefits: (1)
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Treatment of muscle spasms with oral dantrolene sodium
Oral Surgery, Oral Medicine, Oral Pathology, 1989A case of severe muscle spasms relieved by oral administration of dantrolene sodium is presented. The patient had undergone full-mouth extraction 2 days prior to onset of her spasms. The treatment consisted of intravenous diazepam followed by oral dantrolene sodium. The spasms lasted for approximately 10 days.
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117 Update: Dantrolene Sodium Suspension (250 Mg/5mL) in Patients with Exertional Heat Stroke
, 2020M. Greenberg, M. Narurkar, A. Hepner
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