Results 91 to 100 of about 148 (100)

Design, Synthesis and Biological Evaluation of Cycloalkyl Arylpyrimidines (CAPYs) as HIV-1 NNRTIs

Bioorganic and Medicinal Chemistry, 2011
A series of 18 cycloalkyl arylpyrimidines (CAPYs) were designed from lead compounds diarylpyrimidines (DAPYs), synthesized and evaluated for in vitro anti-HIV activity.
Christophe Pannecouque, Erik De Clercq, Fen-Er Chen   +2 more
exaly   +2 more sources

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Improving the Anti-HIV-1 Activity and Solubility of Poorly Water-Soluble DAPYs by Heteroaromatic Replacement Strategy: From Naphthalene-DAPYs to Quinoline-DAPYs

Bioorganic Chemistry, 2023
Christophe Pannecouque, Erik De Clercq, Fen-Er Chen   +2 more
exaly  

Improving Druggability of Novel Diarylpyrimidine NNRTIs by a Fragment-Based Replacement Strategy: From Biphenyl-DAPYs to Heteroaromatic-Biphenyl-DAPYs

Journal of Medicinal Chemistry, 2021
Chunlin Zhuang, Christophe Pannecouque, Erik De Clercq   +2 more
exaly  

Synthesis and Structure–Activity Relationship of Novel Diarylpyrimidines With Hydromethyl Linker (CH(OH)-DAPYs) as HIV-1 NNRTIs

Bioorganic and Medicinal Chemistry, 2011
Christophe Pannecouque, Erik De Clercq, Fen-Er Chen   +2 more
exaly  

Docking-Based 3D-QSAR and Pharmacophore Studies on Diarylpyrimidines as Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase

Molecular Diversity, 2019
Genyan Liu, Shuang-Xi Gu, Xiulian Ju
exaly  

3D-QSAR Studies on DATAs and DAPYs for HIV-RT Inhibitors Using CoMFA and CoMSIA Approaches

QSAR and Combinatorial Science, 2009
Chan Kyung Kim
exaly  

Structure-Based Discovery of Novel Piperidine-Biphenyl-DAPY Derivatives as Non-Nucleoside Reverse Transcriptase Inhibitors Featuring Improved Potency, Safety, and Selectivity: From Piperazine-Biphenyl-DAPYs to Piperidine-Biphenyl-DAPYs

European Journal of Medicinal Chemistry
Christophe Pannecouque, Erik De Clercq, Fen-Er Chen   +2 more
exaly  

Structural Modifications of DAPY Analogues With Potent Anti-HIV-1 Activity

ChemMedChem, 2009
Christophe Pannecouque, Erik De Clercq, Fen-Er Chen   +2 more
exaly  

Recent Developments in the Synthetic Routes Towards Biologically Important Diarylpyrimidines (DAPYs)

ChemistrySelect
Mohd Faheem, Jyoti Pandey, Bal Dev Singh
exaly  

Fragment Addition-Based Design of Heteroaromatic-Biphenyl-DAPYs as Potent and Orally Available Non-Nucleoside Reverse Transcriptase Inhibitors Featuring Significantly Enhanced Safety

Journal of Medicinal Chemistry
Christophe Pannecouque, Erik De Clercq, Fen-Er Chen   +2 more
exaly