Results 71 to 80 of about 148 (100)

Synthesis and anti-human immunodeficiency virus activity of substituted ( o,o-difluorophenyl)-linked-pyrimidines as potent non-nucleoside reverse transcriptase inhibitors. [PDF]

Antivir Chem Chemother, 2019
Čechová L, Dejmek M, Baszczyňski O, Šaman D, Gao L, Hu E, Stepan G, Jansa P, Janeba Z, Šimon P.   +9 more
europepmc   +1 more source

A mechanistic and structural investigation of modified derivatives of the diaryltriazine class of NNRTIs targeting HIV-1 reverse transcriptase. [PDF]

Biochim Biophys Acta, 2014
Mislak AC, Frey KM, Bollini M, Jorgensen WL, Anderson KS.   +4 more
europepmc   +1 more source

A comparison of the ability of rilpivirine (TMC278) and selected analogues to inhibit clinically relevant HIV-1 reverse transcriptase mutants. [PDF]

Retrovirology, 2012
Johnson BC, Pauly GT, Rai G, Patel D, Bauman JD, Baker HL, Das K, Schneider JP, Maloney DJ, Arnold E, Thomas CJ, Hughes SH.   +11 more
europepmc   +1 more source

Conformational landscape of the human immunodeficiency virus type 1 reverse transcriptase non-nucleoside inhibitor binding pocket: lessons for inhibitor design from a cluster analysis of many crystal structures. [PDF]

J Med Chem, 2009
Paris KA, Haq O, Felts AK, Das K, Arnold E, Levy RM.   +5 more
europepmc   +1 more source

Optimization of the antiviral potency and lipophilicity of halogenated 2,6-diarylpyridinamines as a novel class of HIV-1 NNRTIS. [PDF]

ChemMedChem, 2014
Wu ZY, Liu N, Qin B, Huang L, Yu F, Qian K, Morris-Natschke SL, Jiang S, Chen CH, Lee KH, Xie L.   +10 more
europepmc   +1 more source

Design, synthesis, and preclinical evaluations of novel 4-substituted 1,5-diarylanilines as potent HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI) drug candidates. [PDF]

J Med Chem, 2012
Sun LQ, Zhu L, Qian K, Qin B, Huang L, Chen CH, Lee KH, Xie L.   +7 more
europepmc   +1 more source

Diarylaniline derivatives as a distinct class of HIV-1 non-nucleoside reverse transcriptase inhibitors. [PDF]

J Med Chem, 2010
Qin B, Jiang X, Lu H, Tian X, Barbault F, Huang L, Qian K, Chen CH, Huang R, Jiang S, Lee KH, Xie L.   +11 more
europepmc   +1 more source

Antiviral drug discovery and development: challenges and future directions. [PDF]

Signal Transduct Target Ther
Du S, Hu X, Li P, Xu S, Kim M, Liu X, Zhan P.   +6 more
europepmc   +1 more source

An Odyssey in antiviral drug development-50 years at the Rega Institute: 1964-2014. [PDF]

Acta Pharm Sin B, 2015
De Clercq E.
europepmc   +1 more source

Developmental aspects of xenobiotic transformation. [PDF]

Environ Health Perspect, 1976
Klinger W, Muller D.
europepmc   +1 more source