Results 81 to 90 of about 148 (100)
Abstracts of the 14th European Congress of Clinical Microbiology and Infectious Diseases. May 1-4, 2004. Prague, Czech Republic. [PDF]
Clin Microbiol Infect, 2004 europepmc +1 more source
Journal of Medicinal Chemistry, 2022 A series of novel heteroaromatic biphenyl-methyl-pyrimidine analogues were designed via hybridization of privileged structures of two HIV-1 inhibitors.
Chunlin Zhuang +2 more
exaly +7 more sources
European Journal of Medicinal Chemistry, 2020 The fragment hopping approach is widely applied in drug development. A series of diarylpyrimidines (DAPYs) were obtained by hopping the thioacetamide scaffold to novel human immunodeficiency virus type 1 (HIV-1) nonnucleoside reverse transcriptase ...
Chunlin Zhuang +2 more
exaly +2 more sources
Privileged Scaffold Inspired Design of Novel Oxime-Biphenyl-DAPYs in Treatment of HIV-1 [PDF]
Bioorganic Chemistry, 2020 Oxime is a key pharmacophore in drug development. The biphenyl diarylpyrimidines (DAPYs) have been developed by our group as novel non-nucleoside reverse transcriptase inhibitors (NNRTIs).
Chunlin Zhuang +2 more
exaly +2 more sources
Bioorganic Chemistry, 2019 The present work follows our preliminary discovery of biphenyl diarylpyrimidines (DAPYs) as HIV-1 nonnucleoside reverse transcriptase inhibitors. Further structural optimization of biphenyl-DAPYs led to the identification of a new series of biphenyl ...
Chunlin Zhuang +2 more
exaly +2 more sources
Bioorganic and Medicinal Chemistry, 2014 A series of new diarylpyrimidines (DAPYs) characterized by a halogen atom on the methylene linker between wing I and the central pyrimidine ring was synthesized and evaluated for their anti-HIV activity in MT-4 cell cultures.
Christophe Pannecouque +2 more
exaly +2 more sources
Bioorganic and Medicinal Chemistry, 2015 To improve the conformational flexibility and positional adaptability of the traditional diarylpyrimidines (DAPYs), a family of diarylpyrimidines featuring a C-N diatomic linker between the left wing benzene ring and the central pyrimidine was firstly ...
Christophe Pannecouque +2 more
exaly +2 more sources
Bioorganic and Medicinal Chemistry, 2017 30 new analogues of diarylpyrimidines were synthesized for further structural modifications, involving not only the linker but also the wing alpha of DAPYs.
Christophe Pannecouque +2 more
exaly +2 more sources
European Journal of Medicinal Chemistry, 2017 A novel series of uracil-bearing DAPYs derivatives were designed and synthesized via structure-based molecular hybridization to discover compounds with improved anti-resistance profiles. Anti-HIV activity of the designed compounds was tested in MT-4 cell
Zhongxia Zhou, Huiqing Liu, Dongwei Kang
exaly +2 more sources
Bioorganic and Medicinal Chemistry, 2014 A series of CR2(OH)-diarylpyrimidine derivatives (CR2(OH)-DAPYs) featuring a hydrophobic group at CH(OH) linker between wing I and the central pyrimidine were synthesized and evaluated for their anti-HIV activity in MT-4 cell cultures.
Christophe Pannecouque +2 more
exaly +2 more sources