Results 31 to 40 of about 218 (163)
DAPI Fluorescence in Nuclei Isolated from Tumors [PDF]
Journal of Histochemistry & Cytochemistry, 2005 In DNA histograms of some human solid tumors stained with nuclear isolation medium-4,6-diamidino-2-phenylindole dihydrochloride (NIM-DAPI), the coefficient of variation (CV) of the G0/G1 peak was broad, and in nuclear volume vs DNA scattergrams, a prominent slope was seen.
Payal D. Dandekar, Awtar Krishan
openaire +3 more sources
Structure-Based Discovery of Novel Diarylpyrimidines as Potent and Selective Non-Nucleoside Reverse Transcriptase Inhibitors: From CH(CN)-Biphenyl-Diarylpyrimidines to C=NNH2-Biphenyl-Diarylpyrimidines [PDF]
In order to enhance the anti-HIV-1 potency and selectivity of the previously reported compound 3 (EC50 = 27 nM, SI = 1361), a series of novel biphenyl-diarylpyrimidine derivatives were developed by employing structure-based drug design strategy.
Chen, Fen-Er +8 more
core +1 more source
Torsional Dynamics and Orientation of DNA−DAPI Complexes [PDF]
Biochemistry, 1996 The flexibility of calf thymus DNA and several polynucleotides was measured using the anisotropy decay of DAPI bound to DNA, a minor groove probe. DNA torsional dynamics were analyzed using the Schurr model [Allison, S. A., & Schurr, J. M. (1979) Chem. Phys. 41, 35-44] in the infinite polymer length approximation.
Barcellona, Maria Luisa, Gratton, Enrico
openaire +5 more sources
Development of non-nucleoside reverse transcriptase inhibitors (NNRTIs): our past twenty years
Acta Pharmaceutica Sinica B, 2020 Human immunodeficiency virus (HIV) is the primary infectious agent of acquired immunodeficiency syndrome (AIDS), and non-nucleoside reverse transcriptase inhibitors (NNRTIs) are the cornerstone of HIV treatment.
Chunlin Zhuang +3 more
doaj
Survey on Vision-based Path Prediction [PDF]
, 2018 Path prediction is a fundamental task for estimating how pedestrians or vehicles are going to move in a scene. Because path prediction as a task of computer vision uses video as input, various information used for prediction, such as the environment surrounding the target and the internal state of the target, need to be estimated from the video in ...
arxiv +1 more source
Role of Pyrimidine Derivatives in the Treatment of Cancer [PDF]
The study of the chemistry of pyrimidines is contributing to the expansion of research into the therapeutic applications of these compounds. In the field of medicinal chemistry, the sheer number of pyrimidine synthesis methods and reactions that are ...
Dangwal, Kiran +7 more
core +2 more sources
Small, Volume 21, Issue 8, February 25, 2025.This review presents the current state of 2D materials (2DMs) ‐ covalent organic frameworks (COFs) hybrids, focusing on their physicochemical properties, synthesis methods, and applications in sensing, catalysis, energy storage, and filtration. It outlines the strengths and weaknesses of 2DMs and COFs, highlights synergistic benefits from hybridization,
Cataldo Valentini +4 more
wiley +1 more source
Structural modification of diarylpyrimidine derivatives as HIV-1 reverse transcriptase inhibitors [PDF]
, 2014 © 2014 Springer Science+Business Media New York. As a continuing and exploratory work on diarylpyrimidines (DAPYs) as human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) inhibitors, bulky and electron-rich naphthyl was introduced into ...
Christophe Pannecouque +5 more
core +1 more source
Monkeypox: Origin, Transmission, Clinical Manifestations, Prevention, and Therapeutic Options
Interdisciplinary Perspectives on Infectious Diseases, Volume 2025, Issue 1, 2025.Monkeypox is a rapidly spreading transmissible disease induced by the monkeypox virus (MPXV), a major public health problem worldwide. The origin of monkeypox might be tracked to the continent of Africa, where it first afflicted primate species prior to spreading to the world.
Sajal Kumar Halder +4 more
wiley +1 more source
Non-linear stiffness behavior of planar serial robotic manipulators [PDF]
arXiv, 2022 The paper focuses on the stiffness analysis of multi-link serial planar manipulators, which may demonstrate nonlinear stiffness behavior under the compressive loading. Two important cases are considered, where the manipulator has either a straight or non-straight initial configuration.
arxiv