Results 71 to 80 of about 727,398 (339)

Dark-ages reionization and galaxy formation simulation - IX. Economics of reionizing galaxies

, 2017
Using a series of high-resolution hydrodynamical simulations we show that during the rapid growth of high-redshift (z > 5) galaxies, reserves of molecular gas are consumed over a time-scale of 300Myr, almost independent of feedback scheme.
Duffy, Alan R., Geil, Paul M., Kim, Han-Seek, Mesinger, Andrei, Mutch, Simon J., Poole, Gregory B., Wyithe, J. Stuart B.   +6 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Dark-ages reionization and galaxy formation simulation XI: Clustering and halo masses of high redshift galaxies

, 2017
We investigate the clustering properties of Lyman-break galaxies (LBGs) at $z\sim6$ - $8$. Using the semi-analytical model {\scshape Meraxes} constructed as part of the Dark-ages Reionization And Galaxy-formation Observables from Numerical Simulation ...
Duffy, Alan R., Geil, Paul M., Kim, Han-Seek, Liu, Chuanwu, Mesinger, Andrei, Mutch, Simon J., Park, Jaehong, Poole, Gregory B., Trenti, M., Wyithe, J. Stuart B.   +9 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Recovering 21cm Monopole Signals Without Smoothness

The Open Journal of Astrophysics
We expect the monopole signal at the lowest frequencies below $100\,$MHz to be composed to two components: the deep Rayleigh-Jeans tail of the cosmic microwave background and two distinct features: the dark ages trough at $\sim 17\,$MHz and the cosmic ...
Rugved Pund, Anže Slosar, Aaron Parsons
doaj   +1 more source

Modification of Peak Plasticity Induced by Brief Dark Exposure

Neural Plasticity, 2019
The capacity for neural plasticity in the mammalian central visual system adheres to a temporal profile in which plasticity peaks early in postnatal development and then declines to reach enduring negligible levels.
Alexander J. Lingley, Donald E. Mitchell, Nathan A. Crowder, Kevin R. Duffy   +3 more
doaj   +1 more source

Impact of radiation from primordial black holes on the 21-cm angular-power spectrum in the dark ages [PDF]

, 2022
Yupeng Yang
openalex   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Saving us from the Digital Dark Age: the Austrian perspective [PDF]

, 2021
Martina Trognitz
openalex   +1 more source

Cosmological constraints combining H(z), CMB shift and SNIa observational data

, 2007
Recently H(z) data obtained from differential ages of galaxies have been proposed as a new geometrical probe of dark energy. In this paper we use those data, combined with other background tests (CMB shift and SNIa data), to constrain a set of general ...
Alam U, Bond J R, Chimento L P, Davis T M, Denison D G T, Dicus D A Repko W W, Elgaroy O, Elgaroy O Multamäki T, Elisabetta Majerotto, Gong Y Wang A Wu Q Zhang Y Z, Gong Y G, Goobar A, Jassal H K, Jeffreys H, Kurek A Szydlowski M, Lazkoz R, Nesseris S, Ruth Lazkoz, Rydbeck S Fairbairn M Goobar A, Sahni V, Sahni V, Serra P Heavens A Melchiorri A, Starobinsky A A, Trotta R, Trotta R, Tsujikawa S, Turok N, Väliviita J, Väliviita J, Wang Y Mukherjee P, Wasserman L, Wood-Vasey W M, Wright E L, Wright E L, Wu P X, Xu L I Zhang C W Chang B R Liu H Y, Zech G, Zhang H Zhu Z H, Zunckel C Trotta R   +38 more
core   +1 more source