Results 71 to 80 of about 2,442,143 (290)

Dark Current Evolution in Irradiated MWIR HgCdTe Photodiodes

open access: yesJournal of Electronic Materials, 2023
HgCdTe detectors are a key technology for space-based infrared imagery. Radiation in the space environment afects the performance of these detectors. Gamma and protons irradiation are performed in order to assess the impact of total ionising dose and displacement damage dose on the dark current of mid-wavelength infrared HgCdTe photodiodes.
Dinand, S   +7 more
openaire   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Silicon four element p-i-n photodiode with improved characteristics

open access: yesРадіоелектронні і комп'ютерні системи, 2023
This article presents the results of the development of silicon coordinate p-i-n photodiodes (PD) with improved parameters. The technological possibilities of reducing the gaps between the responsive areas of multi-element PDs were studied.
Mykola Kukurudziak
doaj   +1 more source

Low dark current N structure superlattice MWIR photodetectors [PDF]

open access: yesSPIE Proceedings, 2014
Commercially available read out integrated circuits (ROICs) require the FPA to have high dynamic resistance area product at zero bias (R0A) which is directly related to dark current of the detector. Dark current arises from bulk and surface contributions.
Salihoglu, Omer   +4 more
openaire   +3 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

Capture and Indirect Detection of Inelastic Dark Matter

open access: yes, 2009
We compute the capture rate for Dark Matter in the Sun for models where the dominant interaction with nuclei is inelastic -- the Dark Matter up-scatters to a nearby dark "partner" state with a small splitting of order a 100 keV.
Menon, Arjun   +3 more
core   +1 more source

Dark Current Studies for SwissFEL

open access: yes, 2012
Activation of the surroundings of an accelerator must be quantified and those data provided to the official agencies. This is a necessary step in obtaining the authorization to operate such an accelerator. SwissFEL, being a fourth generation light source, will produce more accelerated charges, which are dumped or lost, than conventional third ...
Pimpec, F. Le   +6 more
openaire   +2 more sources

Current status of direct dark matter detection experiments [PDF]

open access: yesNature Physics, 2017
6 pages, 4 figures, version accepted by Nature ...
Jianglai Liu, Xun Chen, Xiangdong Ji
openaire   +2 more sources

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

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